2015

• Bassi GS, Brognara F, Castania JA, Talbot J, Cunha TM, Cunha FQ, Ulloa L, Kanashiro A, Dias DP, Salgado HC. Baroreflex activation in conscious rats modulates the joint inflammatory response via sympathetic function. Brain Behav Immun. 2015 May 15. In press.

• Bastos Moura JF, Mota JM, Leite CA, Wong DV, Bezerra NP, Brito GA, Lima V, Cunha FQ, Ribeiro RA. A novel model of megavoltage radiation-induced ora mucositis in hamsters: Role of inflammatory cytokines and nitric oxide. Int J Radiat Biol. 2015 Jun;91(6):500-9.

• Benevides L, da Fonseca DM, Donate PB, Tiezzi DG, de Carvalho DD, de Andrade JM, Martins GA, da Silva JS. IL-17 promotes mammary tumor progression by changing the behavior of tumor cells and eliciting tumorigenic neutrophils recruitment. Cancer Res. 2015 Jul 24. In press

• Bomfim GF, Echem C, Martins CB, Costa TJ, Sartoretto SM, Dos Santos RA, Oliveira MA, Akamine EH, Fortes ZB, Tostes RC, Webb RC, Carvalho MH. Toll-like receptor 4 inhibition reduces vascular inflammation in spontaneously hypertensive rats. Life Sci. 2015 Feb 1;122:1-7.

• Borghi SM, Pinho-Ribeiro FA, Zarpelon AC, Cunha TM, Alves-Filho JC, Ferreira SH, Cunha FQ, Casagrande R, Verri WA Jr. Interleukin-10 limits intense acute swimming-induced muscle mechanical hyperalgesia in mice. Exp Physiol. 2015 Apr 20;100(5):531-44.

• Bruder-Nascimento T, Callera GE, Montezano AC, He Y, Antunes TT, Cat AN, Tostes RC, Touyz RM. Vascular injury in diabetic db/db mice is ameliorated by atorvastatin: role of Rac1/2-sensitive Nox-dependent pathways. Clin Sci (Lond). 2015 Apr;128(7):411-23.

• Campo VL, Ivanova IN, Carvalho I, Carneiro ZA, Saalbach G, Schenkman S, Silva, JS, Nepogodiev SA, Field RA. Click chemistry oligomerisation of azido-alkyne-functionalised galactose accesses triazole-linked linear oligomers and macrocycles that inhibit Trypanosoma cruzi macrophage invasion. Tetrahedron. In press

• Cardoso CP, Oliveira AJ, Botoni FA, Rezende IC, Alves-Filho JC, Cunha FQ, Estanislau JA, Magno LA, Rios-Santos F. Interleukin-10 rs2227307 and CXCR2 rs1126579 polymorphisms modulate the predisposition to septic shock. Mem Inst Oswaldo Cruz. 2015 02/06;110(4):453-460.

• Carregaro V, Ribeiro JM, Valenzuela JG, Souza-Júnior DL, Costa DL, Oliveira CJ, Sacramento LA, Nascimento MS, Milanezi CM, Cunha FQ, Silva JS. Nucleosides present on phlebotomine saliva induce immunossuppression and promote the infection establishment. PLoS Negl Trop Dis. 2015 Apr 7;9(4):e0003600.

• Carvalho NB, Oliveira FS, Marinho FA, de Almeida LA, Fahel JS, Báfica A, Rothfuchs AG, Zamboni DS, Caliari MV, Oliveira SC. Nucleotide-binding oligomerization domain-2 (NOD2) regulates type-1 cytokine responses to Mycobacterium avium but is not required for host control of infection. Microbes Infect. 2015 May;17(5):337-44.

• Carvalho TT, Borghi SM, Pinho-Ribeiro FA, Mizokami SS, Cunha TM, Ferreira SH, Cunha FQ, Casagrande R, Verri WA Jr. Granulocyte-colony stimulating factor (G-CSF)-induced mechanical hyperalgesia in mice: Role for peripheral TNFα, IL-1β and IL-10. Eur J Pharmacol. 2015 Feb 15;749:62-72.

• Cerqueira DM, Pereira MSF, Silva ALN, Cunha LD, Zamboni DS. Caspase-1, but not caspase-11, is required for NLRC4-mediated pyroptosis and restriction of infection by flagellated Legionella species in mouse macrophages and in vivo” J. Immunol. 15-01223-FLR. In press

• Chignalia AZ, Oliveira MA, Debbas V, Dull RO, Laurindo FR, Touyz RM, Carvalho MH, Fortes ZB, Tostes RC. Testosterone induces leucocyte migration by NADPH oxidase-driven ROS- and COX2-dependent mechanisms. Clin Sci (Lond). 2015 Jul;129(1):39-48.

• Conte FP, Ferraris FK, Costa TE, Pacheco P, Seito LN, Verri WA Jr, Cunha FQ, Penido C, Henriques MG. Effect of gedunin on acute articular inflammation and hypernociception in mice. Molecules. 2015 Feb 3;20(2):2636-57.

• Costa DL, Cardoso TM, Queiroz A, Milanezi CM, Bacellar O, Carvalho EM, Silva JS. Tr-1-like CD4+CD25-CD127-/lowFOXP3- cells are the main source of interleukin 10 in patients with cutaneous leishmaniasis due to Leishmania braziliensis. J Infect Dis. 2015 Mar 1;211(5):708-18. In press

• Costa TJ, Ceravolo GS, dos Santos RA, de Oliveira MA, Araújo PX, Giaquinto LR, Tostes RC, Akamine EH, Fortes ZB, Dantas AP, Carvalho MH. Association of testosterone with estrogen abolishes the beneficial effects of estrogen treatment by increasing ROS generation in aorta endothelial cells. Am J Physiol Heart Circ Physiol. 2015 Apr 1;308(7):H723-32.

• Cunha EL, Santos CF, Braga FS, Costa JS Silva RC, Favacho HAS, Hage-Melim LIS, Carvalho JCT, Silva CHTP, Santos CBR. Computational investigation of antifungal compounds using molecular modeling and prediction of pharmacokinetic and toxicological properties. Journal of Computational and Theoretical Nanoscience, v. 12, 2015. In press

• de Melo FM, Braga CJ, Pereira FV, Maricato JT, Origassa CS, Souza MF, Melo AC, Silva P, Tomaz SL, Gimenes KP, Scutti JA, Juliano MA, Zamboni DS, Câmara NO, Travassos LR, Ferreira LC, Rodrigues EG. Anti-metastatic immunotherapy based on mucosal administration of flagellin and immunomodulatory P10. Immunol Cell Biol. 2015 Jan;93(1):86-98.

• Dias FC, Mendes-Junior CT, Silva MC, Tristão FS, Dellalibera-Joviliano R, Moreau P, Soares EG, Menezes JG, Schmidt A, Dantas RO, Marin-Neto JA, Silva JS, Donadi EA. Human leucocyte antigen-G (HLA-G) and its murine functional homolog Qa2 in the Trypanosoma cruzi Infection. Mediators Inflamm. 2015;2015:595829.

• Dos Santos CB, Lobato CC, Braga FS, da Silva JC, Favacho HA, Carvalho JC, da Cruz Macedo WJ, Brasil DD, de Paula da Silva CH, da Silva Hage-Melim LI. Rational Design of Antimalarial Drugs Using Molecular Modeling and Statistical Analysis. Curr Pharm Des. 2015 May 28. In press

• Fafá BP, Louzada-Junior P, Titton DC, Zandonade E, Ranza R, Laurindo I, Peçanha P, Ranzolin A, Hayata AL, Duarte A, Silveira IG, Costa I, Macieira JC, Guedes-Barbosa LS, Bertolo MB, Sauma MF, Silva MB, Freire M, Scheinberg MA, Fernandes V, Bianchi W, Miranda JR, Pinheiro GR, Carvalho HM, Brenol CV, Pereira IA, de Castro GR, de Morais JC, Oliveira SK, de Abreu MM, Toledo RA, Pinheiro MM, Vieira WP, Valim V; BIOBADABRASIL. Drug survival and causes of discontinuation of the first anti-TNF in ankylosing spondylitis compared with rheumatoid arthritis: analysis from BIOBADABRASIL. Clin Rheumatol. 2015 May;34(5):921-7.

• Federico LB, Almeida JR, Taft CA, Silva CHTP. Ligand and structure-based drug design as strategies for screening of new BACE1 inhibitor candidates. Curr Phys Chem 5,(2015). In press.

• Ferreira NS, Cau SB, Silva MA, Manzato CP, Mestriner FL, Matsumoto T, Carneiro FS, Tostes RC. Diabetes impairs the vascular effects of aldosterone mediated by G protein-coupled estrogen receptor activation. Front Pharmacol. 2015 Mar 2;6:34.

• Figueredo, A. S.; Oliveira, M. G.; Safadi, G. M. V. V.; Silva, C. H. T. P.; Silva, V. B.; Aquino, G. L. B. The natural alkaloid piperine and its acid and ester synthetic derivatives are acetylcholinesterase inhibitors. Curr Phys Chem 5,(2015). In press.

• França R, Vieira SM, Talbot J, Peres RS, Pinto LG, Zamboni DS, Louzada-Junior P, Cunha FQ, Cunha TM. Expression and activity of NOD1 and NOD2/RIPK2 signalling in mononuclear cells from patients with rheumatoid arthritis. Scand J Rheumatol. 2015 Jul 23:1-5.

• Freitas CS, Roveda AC Jr, Truzzi DR, Garcia AC, Cunha TM, Cunha FQ, Franco DW. Anti-inflammatory and Anti-nociceptive Activity of Ruthenium Complexes with Isonicotinic and Nicotinic Acids (Niacin) as Ligands. J Med Chem. 2015 Jun 11;58(11):4439-48.

• Galvani RG, Lemos R, Areal RB, Salvador PA, Zamboni DS, Wanderley JL, Bonomo A. Disease severity and mortality can be independently regulated in a mouse model of experimental graft versus host disease. PLoS One. 2015 Feb 2;10(2):e0118079.

• Gaspar-Elsas MI, Queto T, Masid-de-Brito D, Vieira BM, de Luca B, Cunha FQ, Xavier-Elsas P. α-Galactosylceramide suppresses murine eosinophil production through interferon-γ-dependent induction of NO synthase and CD95. Br J Pharmacol. 2015 Jul;172(13):3313-25.

• Gonçalves L, Viera J, Silva N, Santos C, Braga F, Costa J, Macêdo W, Silva C, Hage-Melim L, Santos C. A QSAR Study of New Caffeine Derivatives with Epithelial Anticancer Activity. British Journal of Pharmaceutical Research, v. 7, p. 122-139, 2015.

• Kawano DF, Silva CHTP, Taft CA. Quantitative Structure-Activity Relationships (QSAR) based on free resources to predict the antibacterial activities of sulfonamides. Curr Phys Chem 5,(2015). In press.

• Ketelut-Carneiro N, Silva GK, Rocha FA, Milanezi CM, Cavalcanti-Neto FF, Zamboni DS, Silva JS. IL-18 triggered by the Nlrp3 inflammasome induces host innate resistance in a pulmonary model of fungal infection. J Immunol. 2015 May 1;194(9):4507-17.

• Leite FR, de Aquino SG, Guimarães MR, Cirelli JA, Zamboni DS, Silva JS, Junior CR. Relevance of the myeloid differentiation factor 88 (MyD88) on RANKL, OPG, and nod expressions induced by TLR and IL-1R signaling in bone marrow stromal cells. Inflammation. 2015 Feb;38(1):1-8.

• Lima LG, Bonardi JM, Campos GO, Bertani RF, Scher LM, Louzada-Junior P, Moriguti JC, Ferriolli E, Lima NK. Effect of aerobic training and aerobic and resistance training on the inflammatory status of hypertensive older adults. Aging Clin Exp Res. 2015 Aug;27(4):483-9.

• Lisboa SF, Gomes FV, Silva AL, Uliana DL, Camargo LH, Guimarães FS, Cunha FQ, Joca SR, Resstel LB. Increased Contextual Fear Conditioning in iNOS Knockout Mice: Additional Evidence for the Involvement of Nitric Oxide in Stress-Related Disorders and Contribution of the Endocannabinoid System. Int J Neuropsychopharmacol. 2015 Jan 24;18(8). In press

• Lopes AH, Talbot J, Silva RL, Lima JB, França RO, Verri WA Jr, Mascarenhas DP, Ryffel B, Cunha FQ, Zamboni DS, Cunha TM. Peripheral NLCR4 inflammasome participates in the genesis of acute inflammatory pain. Pain. 2015 Mar;156(3):451-9.

• Macedo C, Oliveira EH, Almeida RS, Donate PB, Fornari TA, Pezzi N, Sakamoto-Hojo ET, Donadi EA, Passos GA. Aire-dependent peripheral tissue antigen mRNAs in mTEC cells feature networking refractoriness to microRNA interaction. Immunobiology. 2015 Jan;220(1):93-102.

• Mascarenhas DP, Pereira MS, Manin GZ, Hori JI, Zamboni DS. Interleukin 1 receptor-driven neutrophil recruitment accounts to MyD88-dependent pulmonary clearance of legionella pneumophila infection in vivo. J Infect Dis. 2015 Jan 15;211(2):322-30.

• Matsumoto T, Goulopoulou S, Taguchi K, Tostes RC, Kobayashi T. Constrictor prostanoids and uridine adenosine tetraphosphate: vascular mediators and therapeutic targets in hypertension and diabetes. Br J Pharmacol. 2015 Aug;172(16):3980-4001.

• Mota LM, Cruz BA, Brenol CV, Pollak DF, Pinheiro Gda R, Laurindo IM, Pereira IA, Carvalho JF, Bertolo MB, Pinheiro Mde M, Freitas MV, Silva NA, Louzada-Júnior P, Sampaio-Barros PD, Giorgi RD, Lima RA, Andrade LE.Segurança do uso de terapias biológicas para o tratamento de artrite reumatoide e espondiloartrites. Rev Bras Reumatol. 2015 May-Jun;55(3):281-309.

• Nascimento MS, Carregaro V, Lima-Júnior DS, Costa DL, Ryffel B, Duthie MS, de Jesus A, de Almeida RP, da Silva JS. Interleukin 17A acts synergistically with interferon γ to promote protection against Leishmania infantum infection. J Infect Dis. 2015 Mar 15;211(6):1015-26.

•Parra RS, Lopes AH, Carreira EU, Feitosa MR, Cunha FQ, Garcia SB, Cunha TM, da Rocha JJ, Féres O. Hyperbaric oxygen therapy ameliorates TNBS-induced acute distal colitis in rats. Med Gas Res. 2015 Apr 16;5:6.

• Patricio ES, Costa R, Figueiredo CP, Gers-Barlag K, Bicca MA, Manjavachi MN, Segat GC, Gentry C, Luiz AP, Fernandes ES, Cunha TM, Bevan S, Calixto JB. Mechanisms Underlying the Scratching Behavior Induced by the Activation of Proteinase Activated Receptor-4 (PAR-4) in Mice. J Invest Dermatol. 2015 May 8. In Press

• Peres RS, Liew FY, Talbot J, Carregaro V, Oliveira RD, Almeida SL, França RF, Donate PB, Pinto LG, Ferreira FI, Costa DL, Demarque DP, Gouvea DR, Lopes NP, Queiroz RH, Silva JS, Figueiredo F, Alves-Filho JC, Cunha TM, Ferreira SH, Louzada-Junior P, Cunha FQ. Low expression of CD39 on regulatory T cells as a biomarker for resistance to methotrexate therapy in rheumatoid arthritis. Proc Natl Acad Sci U S A. 2015 Feb 24;112(8):2509-14.

• Pernomian L, da Silva CH. Current basis for discovery and development of aryl hydrocarbon receptor antagonists for experimental and therapeutic use in atherosclerosis. Eur J Pharmacol. 2015 Jul 2;764:118-123.

• Pernomian L, do Prado AF, Gomes MS, Pernomian L, da Silva CH, Gerlach RF, de Oliveira AM. MAS receptors mediate vasoprotective and atheroprotective effects of candesartan upon the recovery of vascular angiotensin-converting enzyme 2-angiotensin-(1-7)-MAS axis functionality. Eur J Pharmacol. 2015 Jul 2;764:173-188. doi: 10.1016/j.ejphar.2015.07.007.

• Picanço L, Castro L, Pinheiro A, Silva K, Souza L, Braga F, Silva C, Santos C, Hage-Melim L. Study of Molecular Docking, Physicochemical and Pharmacokinetic Properties of GSK-3β Inhibitors. British Journal of Pharmaceutical Research, v. 7, p. 152-175, 2015.

• Pinheiro AA, Silva KR, Silva AES, Braga FS, Silva CHTP, Santos CBR, Hage-Melim LIS. In silico identification of BACE-1 inhibitors for the treatment of Alzheimer’s disease: molecular docking, pharmacophore derivation, prediction of activity and synthetic accessibility. British Journal of Pharmaceutical Research, 2015. In press.

• Rodrigues FL, Fais RS, Tostes RC, Carneiro FS. There is a link between erectile dysfunction and heart failure: it could be inflammation. Curr Drug Targets. 2015;16(5):442-50.

• Rodrigues FL, Silva LE, Hott SC, Bomfim GF, da Silva CA, Fazan R Jr, Resstel LB, Tostes RC, Carneiro FS. Toll-like receptor 9 plays a key role in the autonomic cardiac and baroreflex control of arterial pressure. Am J Physiol Regul Integr Comp Physiol. 2015 Apr 15;308(8):R714-23.

• Ruiz-Miyazawa KW, Pinho-Ribeiro FA, Zarpelon AC, Staurengo-Ferrari L, Silva RL, Alves-Filho JC, Cunha TM, Cunha FQ, Casagrande R, Verri WA Jr. Vinpocetine reduces lipopolysaccharide-induced inflammatory pain and neutrophil recruitment in mice by targeting oxidative stress, cytokines and NF-κB. Chem Biol Interact. 2015 Jul 25;237:9-17.

• Santos CF, Silva AES, Martins AML, Silva CHTP, Santos CBR, Hage-Melim LIS. Molecular modeling of peptide derivatives NS3 protease inhibitors of the type 2 dengue virus. Curr Phys Chem 5,(2015). In press.

• Silva MA, Cau SB, Lopes RA, Manzato CP, Neves KB, Bruder-Nascimento T, Mestriner FL, Montezano AC, Cat AN, Touyz RM, Tostes RC. Mineralocorticoid receptor blockade prevents vascular remodelling in a rodent model of type 2 diabetes mellitus. Clin Sci (Lond). 2015 Oct 1;129(7):533-45..

• Silva RL, Lopes AH, França RO, Vieira SM, Silva EC, Amorim RC, Cunha FQ, Pohlit AM, Cunha TM. The quassinoid isobrucein B reduces inflammatory hyperalgesia and cytokine production by post-transcriptional modulation. J Nat Prod. 2015 Feb 27;78(2):241-9.

• Silva NSR, Santos CF, Gonçalves LKS, Braga FS, Silva RC, Costa JS, Silva CHTP, Brasil DSB, Hage-Melim LIS, Santos CBR. Molecular modeling of the major compounds of sesquiterpenes class in copaiba oil-resin. British Journal of Pharmaceutical Research, 2015 In press.

• Souza GR, Cunha TM, Silva RL, Lotufo CM, Verri WA Jr, Funez MI, Villarreal CF, Talbot J, Sousa LP, Parada CA, Cunha FQ, Ferreira SH. Involvement of nuclear factor kappa B in the maintenance of persistent inflammatory hypernociception. Pharmacol Biochem Behav. 2015 Jul;134:49-56.

• Souza LR, Picanço RM, Pinheiro AA, Silva KR, Silva CHTP, Santos CBR, Hage-Melim LIS. Development of Monoamine oxidase B inhibitors for the treatment of Parkinson’s disease. Curr Phys Chem 5,(2015). In press.

• Talbot J, Bianchini FJ, Nascimento DC, Oliveira RD, Souto FO, Pinto LG, Peres RS, Silva JR, Almeida SC, Louzada-Junior P, Cunha TM, Cunha FQ, Alves-Filho JC. CCR2 Expression in Neutrophils Plays a Critical Role in Their Migration Into the Joints in Rheumatoid Arthritis. Arthritis Rheumatol. 2015 Jul;67(7):1751-9.

• Xavier-Elsas P, de Luca B, Queto T, Vieira BM, Masid-de-Brito D, Dahab EC, Alves Filho JC, Cunha FQ, Gaspar-Elsas MI. Blockage of Eosinopoiesis by IL-17A Is Prevented by Cytokine and Lipid Mediators of Allergic Inflammation. Mediators Inflamm. 2015;2015:968932.

• Zamboni DS, Lima-Junior DS. Inflammasomes in host response to protozoan parasites. Immunol Rev. 2015 May;265(1):156-71.