2019

Bruder-Nascimento T, Callera GE, Montezano AC, Belin de Chantemele EJ, Tostes RC, Touyz RM. Atorvastatin inhibits pro-inflammatory actions of aldosterone in vascular smooth muscle cells by reducing oxidative stress. Life Sci. 2019 Mar 15;221:29-34.

Cardozo LE, Russo PST, Gomes-Correia B, Araujo-Pereira M, Sepúlveda-HermosillaG, Maracaja-Coutinho V, Nakaya HI. webCEMiTool: Co-expression Modular AnalysisMade Easy. Front Genet. 2019 Mar 6;10:146.

Corsi-Zuelli F, Fachim HA, Loureiro CM, Shuhama R, Bertozi G, Joca SRL, Menezes PR, Louzada-Junior P, Del-Ben CM. Prolonged Periods of Social Isolation From Weaning Reduce the Anti-inflammatory Cytokine IL-10 in Blood and Brain. Front Neurosci. 2019 Jan 11;12:1011.

de Carvalho RVH, Andrade WA, Lima-Junior DS, Dilucca M, de Oliveira CV, Wang K, Nogueira PM, Rugani JN, Soares RP, Beverley SM, Shao F, Zamboni DS. Leishmania Lipophosphoglycan Triggers Caspase-11 and the Non-canonical Activation of the NLRP3 Inflammasome. Cell Rep. 2019 Jan 8;26(2):429-437.e5.

Hauer V, Risti M, Miranda BLM, da Silva JS, Cidral AL, Pozzi CM, Contieri FLC, Sadissou IA, Donadi EA, Augusto DG, Bicalho MDG. The association of HLA-G polymorphisms and the synergistic effect of sMICA and sHLA-G with chronic kidney disease and allograft acceptance. PLoS One. 2019 Feb 22;14(2):e0212750.

Mascarenhas DPA, Zamboni DS. Inflammasome Activation in Legionella-Infected Macrophages. Methods Mol Biol. 2019;1921:305-319.

Silva RL, Silveira GT, Wanderlei CW, Cecilio NT, Maganin AGM, Franchin M, Marques LMM, Lopes NP, Crippa JA, Guimarães FS, Alves-Filho JCF, Cunha FQ, Cunha TM. DMH-CBD, a cannabidiol analog with reduced cytotoxicity, inhibits TNF production by targeting NF-kB activity dependent on A(2A) receptor. Toxicol Appl  Pharmacol. 2019 Apr 1;368:63-71.

 

2018

Amaral PP, Leonardi T, Han N, Viré E, Gascoigne DK, Arias-Carrasco R, Büscher M, Pandolfini L, Zhang A, Pluchino S, Maracaja-Coutinho V, Nakaya HI, Hemberg M, Shiekhattar R, Enright AJ, Kouzarides T. Genomic positional conservation identifies topological anchor point RNAs linked to developmental loci. Genome Biol. 2018 Mar 15;19(1):32.

Arias-Carrasco R, Vásquez-Morán Y, Nakaya HI, Maracaja-Coutinho V. StructRNAfinder: an automated pipeline and web server for RNA families prediction. BMC Bioinformatics. 2018 Feb 17;19(1):55.

Azevedo PO, Sena IFG, Andreotti JP, Carvalho-Tavares J, Alves-Filho JC, Cunha TM, Cunha FQ, Mintz A, Birbrair A. Pericytes modulate myelination in the central nervous system. J Cell Physiol. 2018 Aug;233(8):5523-5529.

Barros JBS, da Silva PAN, Koga RCR, Gonzalez-Dias P, Carmo Filho JR, Nagib PRA, Coelho V, Nakaya HI, Fonseca SG, Pfrimer IAH. Acute Zika Virus Infection in an Endemic Area Shows Modest Proinflammatory Systemic Immunoactivation and Cytokine-Symptom Associations. Front Immunol. 2018 May 3;9:821.

Bassi GS, Kanashiro A, Rodrigues GJ, Cunha FQ, Coimbra NC, Ulloa L. Brain Stimulation Differentially Modulates Nociception and Inflammation in Aversive and Non-aversive Behavioral Conditions. Neuroscience. 2018 Jul 15;383:191-204.

Bassi GS, Ulloa L, Santos VR, Del Vecchio F, Delfino-Pereira P, Rodrigues GJ, Castania JA, Cunha FQ, Salgado HC, Cunha TM, Garcia-Cairasco N, Kanashiro A. Cortical stimulation in conscious rats controls joint inflammation. Prog Neuropsychopharmacol Biol Psychiatry. 2018 Jun 8;84(Pt A):201-213.

Casarotto PC, Biojone C, Montezuma K, Cunha FQ, Joca SRL, Castren E, Guimaraes FS. Inducible nitric oxide synthase (NOS2) knockout mice as a model of trichotillomania. PeerJ. 2018 Apr 17;6:e4635. doi: 10.7717/peerj.4635. eCollection 2018.

Costa RM, Neves KB, Tostes RC, Lobato NS. Perivascular Adipose Tissue as a Relevant Fat Depot for Cardiovascular Risk in Obesity. Front Physiol. 2018 Mar 21;9:253.

da Costa RM, da Silva JF, Alves JV, Dias TB, Rassi DM, Garcia LV, Lobato NS, Tostes RC. Increased O-GlcNAcylation of Endothelial Nitric Oxide Synthase Compromises the Anti-contractile Properties of Perivascular Adipose Tissue in Metabolic Syndrome. Front Physiol. 2018 Apr 6;9:341.

Dela Justina V, Dos Passos Junior RR, Bressan AF, Tostes RC, Carneiro FS, Soares TS, Volpato GT, Lima VV, Martin SS, Giachini FR. O-linked N-acetyl-glucosamine deposition in placental proteins varies according to maternal glycemic levels. Life Sci. 2018 Jul 15;205:18-25.

Ferreira GR, Nakaya HI, Costa LDF. Gene regulatory and signaling networks exhibit distinct topological distributions of motifs. Phys Rev E. 2018 Apr;97(4-1):042417.

Kannen V, Sakita JY, Carneiro ZA, Bader M, Alenina N, Teixeira RR, de Oliveira EC, Brunaldi MO, Gasparotto B, Sartori DC, Fernandes CR, Silva JS, Andrade MV, Silva WA Jr, Uyemura SA, Garcia SB. Mast Cells and Serotonin Synthesis Modulate Chagas Disease in the Colon: Clinical and Experimental Evidence. Dig Dis Sci. 2018 Jun;63(6):1473-1484. 

Ketelut-Carneiro N, Ghosh S, Levitz SM, Fitzgerald KA, da Silva JS. A Dectin-1-Caspase-8 Pathway Licenses Canonical Caspase-1 Inflammasome Activation and Interleukin-1β Release in Response to a Pathogenic Fungus. J Infect Dis. 2018 Jan 4;217(2):329-339.

Lago AF, de Oliveira AS, de Souza HCD, da Silva JS, Basile-Filho A, Gastaldi AC. The effects of physical therapy with neuromuscular electrical stimulation in patients with septic shock: Study protocol for a randomized cross-over design. Medicine (Baltimore). 2018 Feb;97(6):e9736.

Rocha LW, Sonza DR, Broering MF, Nunes R, de Campos-Buzzi F, Corrêa R, Silva RL, Cunha TM, Santin JR, Quintão NLM. Synthetic chalcones as potential tool for acute- and chronic-pain control. Biomed Pharmacother. 2018 Aug;104:437-450.

Rossato MF, Rigo FK, Oliveira SM, Guerra GP, Silva CR, Cunha TM, Gomez MV, Ferreira J, Trevisan G. Participation of transient receptor potential vanilloid 1 in paclitaxel-induced acute visceral and peripheral nociception in rodents. Eur J Pharmacol. 2018 Jun 5;828:42-51.

Ruiz-Miyazawa KW, Pinho-Ribeiro FA, Borghi SM, Staurengo-Ferrari L, Fattori V, Amaral FA, Teixeira MM, Alves-Filho JC, Cunha TM, Cunha FQ, Casagrande R, Verri WA Jr. Hesperidin Methylchalcone Suppresses Experimental Gout Arthritis in Mice by Inhibiting NF-κB Activation. J Agric Food Chem. 2018 Jun 27;66(25):6269-6280.

Russo PST, Ferreira GR, Cardozo LE, Bürger MC, Arias-Carrasco R, Maruyama SR, Hirata TDC, Lima DS, Passos FM, Fukutani KF, Lever M, Silva JS, Maracaja-Coutinho V, Nakaya HI. CEMiTool: a Bioconductor package for performing comprehensive modular co-expression analyses. BMC Bioinformatics. 2018 Feb 20;19(1):56.

Silva MC, Davoli-Ferreira M, Medina TS, Sesti-Costa R, Silva GK, Lopes CD, Cardozo LE, Gava FN, Lyroni K, Dias FC, Frade AF, Baron M, Nakaya HI, Figueiredo F, Alves-Filho JC, Cunha FQ, Tsatsanis C, Chevillard C, Cunha-Neto E, Hirsch E, Silva JS, Cunha TM. Canonical PI3Kγ signaling in myeloid cells restricts Trypanosoma cruzi infection and dampens chagasic myocarditis. Nat Commun. 2018 Apr 17;9(1):1513.

Sisti F, Wang S, Brandt SL, Glosson-Byers N, Mayo LD, Son YM, Sturgeon S, Filgueiras L, Jancar S, Wong H, Dela Cruz CS, Andrews N, Alves-Filho JC, Cunha FQ, Serezani CH. Nuclear PTEN enhances the maturation of a microRNA regulon to limit MyD88-dependent susceptibility to sepsis. Sci Signal. 2018 May 1;11(528).

Sônego F, Castanheira FVS, Horta CV, Kanashiro A, Czaikoski PG, Zamboni DS, Alves-Filho JC, Cunha FQ. The host control of a clinical isolate strain of P. aeruginosa infection is independent of Nod-1 but depends on MyD88. Inflamm Res. 2018 May;67(5):435-443.

Staurengo-Ferrari L, Trevelin SC, Fattori V, Nascimento DC, de Lima KA, Pelayo JS, Figueiredo F, Casagrande R, Fukada SY, Teixeira MM, Cunha TM, Liew FY, Oliveira RD, Louzada-Junior P, Cunha FQ, Alves-Filho JC, Verri WA. Interleukin-33 Receptor (ST2) Deficiency Improves the Outcome of Staphylococcus aureus-Induced Septic Arthritis. Front Immunol. 2018 May 16;9:962.

Talbot J, Peres RS, Pinto LG, Oliveira RDR, Lima KA, Donate PB, Silva JR, Ryffel B, Cunha TM, Alves-Filho JC, Liew FY, Louzada-Junior P, de Queiroz Cunha F. Smoking-induced aggravation of experimental arthritis is dependent of aryl hydrocarbon receptor activation in Th17 cells. Arthritis Res Ther. 2018 Jun 8;20(1):119.

Vernal S, Brochado MJF, Bueno-Filho R, Louzada-Junior P, Roselino AM. Anti-phospholipid syndrome in seven leprosy patients with thrombotic events on corticosteroid and/or thalidomide regimen: insights on genetic and laboratory profiles. Rev Soc Bras Med Trop. 2018 Jan-Feb;51(1):99-104.

2017

Addobbati C, da Cruz HLA, Adelino JE, Melo Tavares Ramos AL, Fragoso TS, Domingues A, Branco Pinto Duarte ÂL, Oliveira RDR, Louzada-Júnior P, Donadi EA, Pontillo A, de Azevêdo Silva J, Crovella S, Sandrin-Garcia P. Polymorphisms and expression of inflammasome genes are associated with the development and severity of rheumatoid arthritis in Brazilian patients. Inflamm Res. 2018 Mar;67(3):255-264. 

Alves-Lopes RU, Neves KB, Silva MA, Olivon VC, Ruginsk SG, Antunes-Rodrigues J, Ramalho LN, Tostes RC, Carneiro FS. Functional and structural changes in internal pudendal arteries underlie erectile dysfunction induced by androgen deprivation. Asian J Androl. 2017 Sep-Oct;19(5):526-532.

Anatriello E, Oliveira CJF, Oliveira NB, Fisch A, Milanezi CM, da Silva JS, de Miranda-Santos IKF, Ferreira BR. Interaction between saliva’s adenosine and tick parasitism: effects on feeding and reproduction. Parasit Vectors. 2017 Jul 10;10(1):326.

Andrade WA, Zamboni DS. Inflammasome-dependent Mechanisms Involved in Sensing and Restriction of Bacterial Replication. Curr Issues Mol Biol. 2017 Sep 6;25:99-132. doi: 10.21775/cimb.025.099. [Epub ahead of print] PubMed PMID: 28875942.

Bassi GS, Dias DPM, Franchin M, Talbot J, Reis DG, Menezes GB, Castania JA, Garcia-Cairasco N, Resstel LBM, Salgado HC, Cunha FQ, Cunha TM, Ulloa L, Kanashiro A. Modulation of experimental arthritis by vagal sensory and central brain stimulation. Brain Behav Immun. 2017 Aug;64:330-343.

Becari C, Silva MAB, Durand MT, Prado CM, Oliveira EB, Ribeiro MS, Salgado HC, Salgado MCO, Tostes RC. Elastase-2, an angiotensin II-generating enzyme, contributes to increased angiotensin II in resistance arteries of mice with myocardial infarction. Br J Pharmacol. 2017 May;174(10):1104-1115.

Bertozzi MM, Rossaneis AC, Fattori V, Longhi-Balbinot DT, Freitas A, Cunha FQ, Alves-Filho JC, Cunha TM, Casagrande R, Verri WA Jr. Diosmin reduces chronic constriction injury-induced neuropathic pain in mice. Chem Biol Interact. 2017 Aug 1;273:180-189.

Braga TT, Correa-Costa M, Silva RC, Cruz MC, Hiyane MI, da Silva JS, Perez KR, Cuccovia IM, Camara NO. CCR2 contributes to the recruitment of monocytes and leads to kidney inflammation and fibrosis development. Inflammopharmacology. 2017 Feb 6.

BRITO MFB, FERREIRA JV, SOUZA LR, GEMAQUE LR, SOUSA KP, SANTOS CF, BRAGA FS, PERNOMIAN L, SILVA CHTP, SANTOS CBR, TAFT CA, HAGE-MELIM LI. Computational Molecular Modeling of Compounds from Amaryllidaceae Family as Potential Acetylcholinesterase Inhibitors. CURRENT BIOACTIVE COMPOUNDS, v. 13, p. 121-129, 2017.

Carlos D, Costa FR, Pereira CA, Rocha FA, Yaochite JN, Oliveira GG, Carneiro FS, Tostes RC, Ramos SG, Zamboni DS, Camara NO, Ryffel B, Silva JS. Mitochondrial DNA Activates the NLRP3 Inflammasome and Predisposes to Type 1 Diabetes in Murine Model. Front Immunol. 2017 Feb 27;8:164.

Chen W, Foo SS, Zaid A, Teng TS, Herrero LJ, Wolf S, Tharmarajah K, Vu LD, van Vreden C, Taylor A, Freitas JR, Li RW, Woodruff TM, Gordon R, Ojcius DM, Nakaya HI, Kanneganti TD, O’Neill LAJ, Robertson AAB, King NJ, Suhrbier A, Cooper MA, Ng LFP, Mahalingam S. Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammation. Nat Microbiol. 2017 Aug 28.

Côco H, Pernomian L, Pereira PC, Gomes MS, Marchi KC, Lopes AH, Cunha TM, Tirapelli CR, de Oliveira AM. Chronic restraint stress increases angiotensin II potency in the rat carotid: role of cyclooxygenases and reactive oxygen species. J Pharm Pharmacol. 2017 Jan;69(1):52-65.

Costa JDS, Costa KDSL, Cruz JV, Ramosb RDS, Silva LB, Barros Brasilc DDS, Henrique Tomich de Paula da Silva C, Santos CBRD, Macêdoe WJDC. Virtual screening and statistical analysis in the design of new caffeine analogues molecules with potential epithelial anticancer activity. Curr Pharm Des. 2017 Jul 11.

Costa VV, Del Sarto JL, Rocha RF, Silva FR, Doria JG, Olmo IG, Marques RE, Queiroz-Junior CM, Foureaux G, Araújo JMS, Cramer A, Real ALCV, Ribeiro LS, Sardi SI, Ferreira AJ, Machado FS, de Oliveira AC, Teixeira AL, Nakaya HI, Souza DG, Ribeiro FM, Teixeira MM. N-Methyl-d-Aspartate (NMDA) Receptor Blockade Prevents Neuronal Death Induced by Zika Virus Infection. MBio. 2017 Apr 25;8(2).

Cunha LD, Silva ALN, Ribeiro JM, Mascarenhas DPA, Quirino GFS, Santos LL, Flavell RA, Zamboni DS. AIM2 Engages Active but Unprocessed Caspase-1 to Induce Noncanonical Activation of the NLRP3 Inflammasome. Cell Rep. 2017 Jul 25;20(4):794-805.

da Costa RM, Fais RS, Dechandt CRP, Louzada-Junior P, Alberici LC, Lobato NS, Tostes RC. Increased mitochondrial ROS generation mediates the loss of the anti-contractile effects of perivascular adipose tissue in high-fat diet obese mice. Br J Pharmacol. 2017 Oct;174(20):3527-3541.

da Silva CHTP, Taft CA. 3D descriptors calculation and conformational search to investigate potential bioactive conformations, with application in 3D-QSAR and virtual screening in drug design. J Biomol Struct Dyn. 2017 Oct;35(13):2966-2974.

Dal-Secco D, DalBó S, Lautherbach NES, Gava FN, Celes MRN, Benedet PO, Souza AH, Akinaga J, Lima V, Silva KP, Kiguti LRA, Rossi MA, Kettelhut IC, Pupo AS, Cunha FQ, Assreuy J. Cardiac hyporesponsiveness in severe sepsis is associated with nitric oxide-dependent activation of G protein receptor kinase. Am J Physiol Heart Circ Physiol. 2017 Jul 1;313(1):H149-H163.

Dalto VF, Assad RL, Crema MD, Louzada-Junior P, Nogueira-Barbosa MH. MRI assessment of bone marrow oedema in the sacroiliac joints of patients with spondyloarthritis: is the SPAIR T2w technique comparable to STIR? Eur Radiol. 2017 Sep;27(9):3669-3676.

de Aquino SG, Talbot J, Sônego F, Turato WM, Grespan R, Avila-Campos MJ, Cunha FQ, Cirelli JA. The aggravation of arthritis by periodontitis is dependent of IL-17 receptor A activation. J Clin Periodontol. 2017 Sep;44(9):881-891.

de Carvalho LM, Ngoumou G, Park JW, Ehmke N, Deigendesch N, Kitabayashi N, Melki I, Souza FFL, Tzschach A, Nogueira-Barbosa MH, Ferriani V, Louzada-Junior P, Marques W Jr, Lourenço CM, Horn D, Kallinich T, Stenzel W, Hur S, Rice GI, Crow YJ. Musculoskeletal Disease in MDA5-Related Type I Interferonopathy: A Mendelian Mimic of Jaccoud’s Arthropathy. Arthritis Rheumatol. 2017 Oct;69(10):2081-2091.

de Oliveira CE, Gasparoto TH, Pinheiro CR, Amôr NG, Nogueira MRS, Kaneno R, Garlet GP, Lara VS, da Silva JS, Cavassani KA, Campanelli AP. CCR5-dependent homing of T regulatory cells to the tumor microenvironment contributes to skin squamous cell carcinoma development. Mol Cancer Ther. 2017 Sep 13.

de Oliveira LSS, de Araújo AA, de Araújo Júnior RF, Barboza CAG, Borges BCD, da Silva JSP. Low-level laser therapy (780 nm) combined with collagen sponge scaffold promotes repair of rat cranial critical-size defects and increases TGF-β, FGF-2, OPG/RANK and osteocalcin expression. Int J Exp Pathol. 2017 May 29.

Dela Justina V, Gonçalves JS, de Freitas RA, Fonseca AD, Volpato GT, Tostes RC, Carneiro FS, Lima VV, Giachini FR. Increased O-Linked N-Acetylglucosamine Modification of NF-ΚB and Augmented Cytokine Production in the Placentas from Hyperglycemic Rats. Inflammation. 2017 Jul 8.

Dias RG, Sampaio SC, Sant’Anna MB, Cunha FQ, Gutiérrez JM, Lomonte B, Cury Y, Picolo G. Articular inflammation induced by an enzymatically-inactive Lys49 phospholipase A(2): activation of endogenous phospholipases contributes to the pronociceptive effect. J Venom Anim Toxins Incl Trop Dis. 2017 Mar 23;23:18.

DINIZ EMLP, POIANI JGC, TAFT CA, SILVA CHTP. Structure-based drug design, molecular dynamics and ADME/Tox to investigate protein kinase anti-cancer agents. CURRENT BIOACTIVE COMPOUNDS, v. 13, p. yy-yyy, 2017.

Diniz EMLP, Tomich de Paula da Silva CH, Gómez-Perez V, Federico LB, Campos Rosa JM. GRIND2-based 3D-QSAR and prediction of activity spectra for symmetrical bis-pyridinium salts with promastigote antileishmanial activity. J Biomol Struct Dyn. 2017 Aug;35(11):2430-2440.

Eugenia Schroeder M, Russo S, Costa C, Hori J, Tiscornia I, Bollati-Fogolín M, Zamboni DS, Ferreira G, Cairoli E, Hill M. Pro-inflammatory Ca(++)-activated K(+) channels are inhibited by hydroxychloroquine. Sci Rep. 2017 May 15;7(1):1892.

Fattori V, Hohmann MSN, Rossaneis AC, Manchope MF, Alves-Filho JC, Cunha TM, Cunha FQ, Verri WA Jr. Targeting IL-33/ST2 signaling: regulation of immune function and analgesia. Expert Opin Ther Targets. 2017 Dec;21(12):1141-1152. 

Fattori V, Serafim KG, Zarpelon AC, Borghi SM, Pinho-Ribeiro FA, Alves-Filho JC, Cunha TM, Cunha FQ, Casagrande R, Verri WA Jr. Differential regulation of oxidative stress and cytokine production by endothelin ET(A) and ET(B) receptors in superoxide anion-induced inflammation and pain in mice. J Drug Target. 2017 Mar;25(3):264-274.

Feriotti C, de Araújo EF, Loures FV, da Costa TA, Galdino NAL, Zamboni DS, Calich VLG. NOD-Like Receptor P3 Inflammasome Controls Protective Th1/Th17 Immunity against Pulmonary Paracoccidioidomycosis. Front Immunol. 2017 Jul 10;8:786.

Ferreira JV, Chaves GA, Marino BLB, Sousa KPA, Souza LR, Brito MFB, Teixeira HRC, da Silva CHTP, Santos CBR, Hage-Melim LIS. Cannabinoid Type 1 Receptor (CB1) Ligands with Therapeutic Potential for Withdrawal Syndrome in Chemical Dependents of Cannabis sativa. ChemMedChem. 2017 Aug 22;12(16):1408-1416.

Ferreira LR, Ferreira FM, Nakaya HI, Deng X, Cândido DD, de Oliveira LC, Billaud JN, Lanteri MC, Rigaud VO, Seielstad M, Kalil J, Fernandes F, Ribeiro AL, Sabino EC, Cunha-Neto E. Blood Gene Signatures of Chagas Cardiomyopathy With or Without Ventricular Dysfunction. J Infect Dis. 2017 Feb 1;215(3):387-395.

Franco LH, Fleuri AKA, Pellison NC, Quirino GFS, Horta CV, de Carvalho RVH, Oliveira SC, Zamboni DS. Autophagy downstream of endosomal Toll-like receptor signaling in macrophages is a key mechanism for resistance to Leishmania major infection. J Biol Chem. 2017 Aug 11;292(32):13087-13096.

Geraldo MV, Nakaya HI, Kimura ET. Down-regulation of 14q32-encoded miRNAs and tumor suppressor role for miR-654-3p in papillary thyroid cancer. Oncotarget. 2017 Feb 7;8(6):9597-9607.

Gonçalves AC, Ferreira LS, Manente FA, de Faria CMQG, Polesi MC, de Andrade CR, Zamboni DS, Carlos IZ. The NLRP3 inflammasome contributes to host protection during Sporothrix schenckii infection. Immunology. 2017 Jun;151(2):154-166.

Guimarães FR, Sales-Campos H, Nardini V, da Costa TA, Fonseca MTC, Júnior VR, Sorgi CA, da Silva JS, Chica JEL, Faccioli LH, de Barros Cardoso CR. The inhibition of 5-lipoxygenase (5-LO) products leukotriene B4 (LTB(4)) and cysteinyl leukotrienes (cysLTs) modulates the inflammatory response and improves cutaneous wound healing. Clin Immunol. 2017 Sep 28.

Kanashiro A, Franchin M, Bassi GS, Reis Santana DA, Cunha TM, Cunha FQ, Ulloa L, Rodrigues GJ. Inhibition of spinal p38 MAPK prevents articular neutrophil infiltration in experimental arthritis via sympathetic activation. Fundam Clin Pharmacol. 2018 Apr;32(2):155-162. 

Kanashiro A, Sônego F, Ferreira RG, Castanheira FV, Leite CA, Borges VF, Nascimento DC, Cólon DF, Alves-Filho JC, Ulloa L, Cunha FQ. Therapeutic potential and limitations of cholinergic anti-inflammatory pathway in sepsis. Pharmacol Res. 2017 Mar;117:1-8.

Kasturi SP, Kozlowski PA, Nakaya HI, Burger MC, Russo P, Pham M, Kovalenkov Y, Silveira EL, Havenar-Daughton C, Burton SL, Kilgore KM, Johnson MJ, Nabi R, Legere T, Sher ZJ, Chen X, Amara RR, Hunter E, Bosinger SE, Spearman P, Crotty S, Villinger F, Derdeyn CA, Wrammert J, Pulendran B. Adjuvanting a Simian Immunodeficiency Virus Vaccine with Toll-Like Receptor Ligands Encapsulated in Nanoparticles Induces Persistent Antibody Responses and Enhanced Protection in TRIM5α Restrictive Macaques. J Virol. 2017 Jan 31;91(4).

Kazmin D, Nakaya HI, Lee EK, Johnson MJ, van der Most R, van den Berg RA, Ballou WR, Jongert E, Wille-Reece U, Ockenhouse C, Aderem A, Zak DE, Sadoff J, Hendriks J, Wrammert J, Ahmed R, Pulendran B. Systems analysis of protective immune responses to RTS,S malaria vaccination in humans. Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):2425-2430.

Khalid KE, Nascimento MSL, Sacramento LA, Costa DL, Lima-Júnior DS, Carregaro V, da Silva JS. T1/ST2 deficient mice display protection against Leishmania infantum experimental infection. Acta Trop. 2017 Aug;172:1-6.

Lever M, Silveira EL, Nakaya HI. Systems Vaccinology Applied to DNA Vaccines: Perspective and Challenges. Curr Issues Mol Biol. 2017;22:1-16. Review. PubMed PMID: 27648510.

Li S, Sullivan NL, Rouphael N, Yu T, Banton S, Maddur MS, McCausland M, Chiu C, Canniff J, Dubey S, Liu K, Tran V, Hagan T, Duraisingham S, Wieland A, Mehta AK, Whitaker JA, Subramaniam S, Jones DP, Sette A, Vora K, Weinberg A, Mulligan MJ, Nakaya HI, Levin M, Ahmed R, Pulendran B. Metabolic Phenotypes of Response to Vaccination in Humans. Cell. 2017 May 18;169(5):862-877.e17.

Lima HR, Gasparoto TH, de Souza Malaspina TS, Marques VR, Vicente MJ, Marcos EC, Souza FC, Nogueira MRS, Barreto JA, Garlet GP, da Silva JS, Brito-de-Souza VN, Campanelli AP. Immune Checkpoints in Leprosy: Immunotherapy As a Feasible Approach to Control Disease Progression. Front Immunol. 2017 Dec 11;8:1724. 

Lima MHF, Sacramento LA, Quirino GFS, Ferreira MD, Benevides L, Santana AKM, Cunha FQ, Almeida RP, Silva JS, Carregaro V. Leishmania infantum Parasites Subvert the Host Inflammatory Response through the Adenosine A2(A) Receptor to Promote the Establishment of Infection. Front Immunol. 2017 Jul 20;8:815.

Lima-Junior DS, Mineo TWP, Calich VLG, Zamboni DS. Dectin-1 Activation during Leishmania amazonensis Phagocytosis Prompts Syk-Dependent Reactive Oxygen Species Production To Trigger Inflammasome Assembly and Restriction of Parasite Replication. J Immunol. 2017 Sep 15;199(6):2055-2068.

Lisboa SF, Issy AC, Biojone C, Montezuma K, Fattori V, Del-Bel EA, Guimarães FS, Cunha FQ, Verri WA Jr, Joca SRL. Mice lacking interleukin-18 gene display behavioral changes in animal models of psychiatric disorders: Possible involvement of immunological mechanisms. J Neuroimmunol. 2018 Jan 15;314:58-66. 

Lucetti LT, Silva RO, Santana AP, de Melo Tavares B, Vale ML, Soares PM, de Lima Júnior FJ, Magalhães PJ, de Queiroz Cunha F, de Albuquerque Ribeiro R, Medeiros JR, Souza MH. Nitric Oxide and Hydrogen Sulfide Interact When Modulating Gastric Physiological Functions in Rodents. Dig Dis Sci. 2017 Jan;62(1):93-104.

Madeira MFM, Queiroz Junior CM, Corrêa JD, Werneck SMC, Machado FS, Cunha TM, Garlet GP, Teixeira MM, da Silva TA, Souza DG. The role of 5-lipoxygenase in Aggregatibacter actinomycetemcomitans-induced alveolar bone loss. J Clin Periodontol. 2017 Jun 1.

Maia PI, Carneiro ZA, Lopes CD, Oliveira CG, Silva JS, de Albuquerque S, Hagenbach A, Gust R, Deflon VM, Abram U. Organometallic gold(iii) complexes withhybrid SNS-donating thiosemicarbazone ligands: cytotoxicity and anti-Trypanosoma cruzi activity. Dalton Trans. 2017 Feb 21;46(8):2559-2571.

Martelli-Palomino G, Paoliello-Paschoalato AB, Crispim JC, Rassi DM, Oliveira RD, Louzada P, Lucisano-Valim YM, Donadi EA. DNA damage increase in peripheral neutrophils from patients with rheumatoid arthritis is associated with the disease activity and the presence of shared epitope. Clin Exp Rheumatol. 2017 Mar-Apr;35(2):247-254.

Mascarenhas DP, Zamboni DS. Inflammasome biology taught by Legionella pneumophila. J Leukoc Biol. 2017 Apr;101(4):841-849.

Mascarenhas DPA, Cerqueira DM, Pereira MSF, Castanheira FVS, Fernandes TD, Manin GZ, Cunha LD, Zamboni DS. Inhibition of caspase-1 or gasdermin-D enable caspase-8 activation in the Naip5/NLRC4/ASC inflammasome. PLoS Pathog. 2017 Aug 3;13(8):e1006502.

Massis LM, Assis-Marques MA, Castanheira FV, Capobianco YJ, Balestra AC, Escoll P, Wood RE, Manin GZ, Correa VM, Alves-Filho JC, Cunha FQ, Buchrieser C, Borges MC, Newton HJ, Zamboni DS. Legionella longbeachae Is Immunologically Silent and Highly Virulent In Vivo. J Infect Dis. 2017 Feb 1;215(3):440-451.

Moreira-Souza ACA, Almeida-da-Silva CLC, Rangel TP, Rocha GDC, Bellio M, Zamboni DS, Vommaro RC, Coutinho-Silva R. The P2X7 Receptor Mediates Toxoplasma gondii Control in Macrophages through Canonical NLRP3 Inflammasome Activation and Reactive Oxygen Species Production. Front Immunol. 2017 Oct 12;8:1257. 

Nascimento DC, Melo PH, Piñeros AR, Ferreira RG, Colón DF, Donate PB, Castanheira FV, Gozzi A, Czaikoski PG, Niedbala W, Borges MC, Zamboni DS, Liew FY, Cunha FQ, Alves-Filho JC. IL-33 contributes to sepsis-induced long-term immunosuppression by expanding the regulatory T cell population. Nat Commun. 2017 Apr 4;8:14919.

Oliveira AC, Gomes-Neto JF, Barbosa CD, Granato A, Reis BS, Santos BM, Fucs R, Canto FB, Nakaya HI, Nóbrega A, Bellio M. Crucial role for T cell-intrinsic IL-18R-MyD88 signaling in cognate immune response to intracellular parasite infection. Elife. 2017 Sep 12;6.

Oliveira ÉA, Lima DS, Cardozo LE, Souza GF, de Souza N, Alves-Fernandes DK, Faião-Flores F, Quincoces JAP, Barros SBM, Nakaya HI, Monteiro G, Maria-Engler SS. Toxicogenomic and bioinformatics platforms to identify key molecular mechanisms of a curcumin-analogue DM-1 toxicity in melanoma cells. Pharmacol Res. 2017 Nov;125(Pt B):178-187.

Parente JM, Pereira CA, Oliveira-Paula GH, Tanus-Santos JE, Tostes RC, Castro MM. Matrix Metalloproteinase-2 Activity is Associated with Divergent Regulation of Calponin-1 in Conductance and Resistance Arteries in Hypertension-induced Early Vascular Dysfunction and Remodelling. Basic Clin Pharmacol Toxicol. 2017 Oct;121(4):246-256.

Pereira AL, Dos Santos GB, Franco MS, Federico LB, da Silva CH, Santos CB. Molecular modeling and statistical analysis in the design of derivatives of human dipeptidyl peptidase IV. J Biomol Struct Dyn. 2017 Jan 24:1-17.

Pereira CA, Rodrigues FL, Ruginsk SG, Zanotto CZ, Rodrigues JA, Duarte DA, Costa-Neto CM, Resstel LB, Carneiro FS, Tostes RC. Chronic treatment with fluoxetine modulates vascular adrenergic responses by inhibition of pre- and post-synaptic mechanisms. Eur J Pharmacol. 2017 Apr 5;800:70-80.

Peres RS, Santos GB, Cecilio NT, Jabor VA, Niehues M, Torres BG, Buqui G, Silva CH, Costa TD, Lopes NP, Nonato MC, Ramalho FS, Louzada-Júnior P, Cunha TM, Cunha FQ, Emery FS, Alves-Filho JC. Lapachol, a compound targeting pyrimidine metabolism, ameliorates experimental autoimmune arthritis. Arthritis Res Ther. 2017 Mar 7;19(1):47.

Pernomian L, Gomes MS, Moreira JD, da Silva CHTP, Rosa JMC, Cardoso CRB. New Horizons on Molecular Pharmacology Applied to Drug Discovery: When Resonance Overcomes Radioligand Binding. Curr Radiopharm. 2017;10(1):16-20.

Piñeros Alvarez AR, Glosson-Byers N, Brandt S, Wang S, Wong H, Sturgeon S, McCarthy BP, Territo PR, Alves-Filho JC, Serezani CH. SOCS1 is a negative regulator of metabolic reprogramming during sepsis. JCI Insight. 2017 Jul 6;2(13).

Piñeros AR, Campos LW, Fonseca DM, Bertolini TB, Gembre AF, Prado RQ, Alves-Filho JC, Ramos SG, Russo M, Bonato VL. M2 macrophages or IL-33 treatment attenuate ongoing Mycobacterium tuberculosis infection. Sci Rep. 2017 Jan 27;7:41240.

Prada-Medina CA, Fukutani KF, Pavan Kumar N, Gil-Santana L, Babu S, Lichtenstein F, West K, Sivakumar S, Menon PA, Viswanathan V, Andrade BB, Nakaya HI, Kornfeld H. Systems Immunology of Diabetes-Tuberculosis Comorbidity Reveals Signatures of Disease Complications. Sci Rep. 2017 May 17;7(1):1999.

Prow NA, Tang B, Gardner J, Le TT, Taylor A, Poo YS, Nakayama E, Hirata TDC, Nakaya HI, Slonchak A, Mukhopadhyay P, Mahalingam S, Schroder WA, Klimstra W, Suhrbier A. Lower temperatures reduce type I interferon activity and promote alphaviral arthritis. PLoS Pathog. 2017 Dec 27;13(12):e1006788. 

Racioppi L, Lento W, Huang W, Arvai S, Doan PL, Harris JR, Marcon F, Nakaya HI, Liu Y, Chao N. Calcium/calmodulin-dependent kinase kinase 2 regulates hematopoietic stem and progenitor cell regeneration. Cell Death Dis. 2017 Oct 5;8(10):e3076.

Ramos-Junior ES, Leite GA, Carmo-Silva CC, Taira TM, Neves KB, Colón DF, da Silva LA, Salvador SL, Tostes RC, Cunha FQ, Fukada SY. Adipokine Chemerin Bridges Metabolic Dyslipidemia and Alveolar Bone Loss in Mice. J Bone Miner Res. 2017 May;32(5):974-984.

Rezende BM, Athayde RM, Gonçalves WA, Resende CB, Teles de Tolêdo Bernardes P, Perez DA, Esper L, Reis AC, Rachid MA, Castor MGME, Cunha TM, Machado FS, Teixeira MM, Pinho V. Inhibition of 5-lipoxygenase alleviates graft-versus-host disease. J Exp Med. 2017 Sep 25.

Rodrigues FL, Fais RS, Pereira MGAG, Garcia-Cairasco N, Tostes RC, Carneiro FS. Erectile Dysfunction in Wistar Audiogenic Rats Is Associated With Increased Cavernosal Contraction and Decreased Neuronal Nitric Oxide Synthase Protein Expression. Urology. 2017 Aug;106:237.e1-237.e8.

Sacramento LA, da Costa JL, de Lima MH, Sampaio PA, Almeida RP, Cunha FQ, Silva JS, Carregaro V. Toll-Like Receptor 2 Is Required for Inflammatory Process Development during Leishmania infantum Infection. Front Microbiol. 2017 Feb 23;8:262.

Santos D, Campos TM, Saldanha M, Oliveira SC, Nascimento M, Zamboni DS, Machado PR, Arruda S, Scott P, Carvalho EM, Carvalho LP. IL-1β Production by Intermediate Monocytes Is Associated with Immunopathology in Cutaneous Leishmaniasis. J Invest Dermatol. 2018 May;138(5):1107-1115. 

Santos MB, de Oliveira DT, Cazzaniga RA, Varjão CS, Dos Santos PL, Santos MLB, Correia CB, Faria DR, Simon MDV, Silva JS, Dutra WO, Reed SG, Duthie MS, de Almeida RP, de Jesus AR. Distinct Roles of Th17 and Th1 Cells in Inflammatory Responses Associated with the Presentation of Paucibacillary Leprosy and Leprosy Reactions. Scand J Immunol. 2017 Jul;86(1):40-49.

Santos-Almeida FM, Domingos-Souza G, Meschiari CA, Fávaro LC, Becari C, Castania JA, Lopes A, Cunha TM, Moraes DJA, Cunha FQ, Ulloa L, Kanashiro A, Tezini GCSV, Salgado HC. Carotid sinus nerve electrical stimulation in conscious rats attenuates systemic inflammation via chemoreceptor activation. Sci Rep. 2017 Jul 24;7(1):6265.

Sesti-Costa R, Françozo MCS, Silva GK, Proenca-Modena JL, Silva JS. TLR3 is required for survival following Coxsackievirus B3 infection by driving T lymphocyte activation and polarization: The role of dendritic cells. PLoS One. 2017 Oct 3;12(10):e0185819.

Silva JR, Lopes AH, Talbot J, Cecilio NT, Rossato MF, Silva RL, Souza GR, Silva CR, Lucas G, Fonseca BA, Arruda E, Alves-Filho JC, Cunha FQ, Cunha TM. Neuroimmune-Glia Interactions in the Sensory Ganglia Account for the Development of Acute Herpetic Neuralgia. J Neurosci. 2017 Jul 5;37(27):6408-6422.

Silva NR, Gomes FV, Fonseca MD, Mechoulam R, Breuer A, Cunha TM, Guimarães FS. Antinociceptive effects of HUF-101, a fluorinated cannabidiol derivative. Prog Neuropsychopharmacol Biol Psychiatry. 2017 Oct 3;79(Pt B):369-377.

Silva RL, Lopes AH, Guimarães RM, Cunha TM. CXCL1/CXCR2 signaling in pathological pain: Role in peripheral and central sensitization. Neurobiol Dis. 2017 Sep;105:109-116.

Simplicio JA, do Vale GT, Gonzaga NA, Leite LN, Hipólito UV, Pereira CA, Tostes RC, Tirapelli CR. Reactive oxygen species derived from NAD(P)H oxidase play a role on ethanol-induced hypertension and endothelial dysfunction in rat resistance arteries. J Physiol Biochem. 2017 Feb;73(1):5-16.

Soares FS, Amaral FC, Silva NLC, Valente MR, Santos LKR, Yamashiro LH, Scheffer MC, Castanheira FVES, Ferreira RG, Gehrke L, Alves-Filho JC, Silva LP, Báfica A, Spiller F. Antibiotic-Induced Pathobiont Dissemination Accelerates Mortality in Severe Experimental Pancreatitis. Front Immunol. 2017 Dec 22;8:1890. 

Souza MC, Fonseca DM, Kanashiro A, Benevides L, Medina TS, Dias MS, Andrade WA, Bonfá G, Silva MAB, Gozzi A, Borges MC, Gazzinelli RT, Alves-Filho JC, Cunha  FQ, Silva JS. Chronic Toxoplasma gondii Infection Exacerbates Secondary Polymicrobial Sepsis. Front Cell Infect Microbiol. 2017 Apr 7;7:116.

Souza-Silva L, Alves-Lopes R, Silva Miguez J, Dela Justina V, Neves KB, Mestriner FL, Tostes RC, Giachini FR, Lima VV. Glycosylation with O-Linked β-N-acetylglucosamine (O-GlcNAc) induces vascular dysfunction via production of superoxide anion / reactive oxygen species. Can J Physiol Pharmacol. 2017 Aug 9.

Spirlandeli AL, Dick-de-Paula I, Zamarioli A, Jorgetti V, Ramalho LNZ, Nogueira-Barbosa MH, Volpon JB, Jordão AA, Cunha FQ, Fukada SY, de Paula FJA. Hepatic Osteodystrophy: The Mechanism of Bone Loss in Hepatocellular Disease and the Effects of Pamidronate Treatment. Clinics (Sao Paulo). 2017 Apr;72(4):231-237.

Teixeira LB, Parreiras-E-Silva LT, Bruder-Nascimento T, Duarte DA, Simões SC, Costa RM, Rodríguez DY, Ferreira PAB, Silva CAA, Abrao EP, Oliveira EB, Bouvier M, Tostes RC, Costa-Neto CM. Ang-(1-7) is an endogenous β-arrestin-biased agonist of the AT(1) receptor with protective action in cardiac hypertrophy. Sci Rep. 2017 Sep 19;7(1):11903.

Toson B, Dos Santos EJ, Adelino JE, Sandrin-Garcia P, Crovella S, Louzada-Júnior P, Oliveira RD, Pedroza LS, de Fátima Lobato Cunha Sauma M, de Lima CP, Barbosa FB, Brenol CV, Xavier RM, Chies JA, Veit TD. CCR5Δ32 and the genetic susceptibility to rheumatoid arthritis in admixed populations: a multicentre study. Rheumatology (Oxford). 2017 Mar 1;56(3):495-497.

Trevelin SC, Carlos D, Beretta M, da Silva JS, Cunha FQ. Diabetes Mellitus and Sepsis: A Challenging Association. Shock. 2017 Mar;47(3):276-287.

Wynne BM, Labazi H, Carneiro ZN, Tostes RC, Webb RC. Angeli’s Salt, a nitroxyl anion donor, reverses endothelin-1 mediated vascular dysfunction in murine aorta. Eur J Pharmacol. 2017 Nov 5;814:294-301.

Wynne BM, Labazi H, Tostes RC, Webb RC. Nitroxyl anion mediates relaxation in mesenteric arteries from angiotensin II hypertensive mice. Curr Vasc Pharmacol. 2017 Jul 25.

Yonekura CL, Oliveira RDR, Titton DC, Ranza R, Ranzolin A, Hayata AL, Duarte Â, Silveira IG, Carvalho HMDS, Moraes JCB, Abreu MM, Valim V, Bianchi W, Brenol CV, Pereira IA, Costa I, Macieira JC, Miranda JRS, Guedes-Barbosa LS, Bertolo MB, Sauma MFLDC, Silva MBG, Freire M, Scheinberg MA, Toledo RA, Oliveira SKF, Fernandes V, Pinheiro MM, Castro G, Vieira WP, Baaklini CE, Ruffino-Netto A, Pinheiro GDRC, Laurindo IMM, Louzada-Junior P. Incidence of tuberculosis among patients with rheumatoid arthritis using TNF blockers in Brazil: data from the Brazilian Registry of Biological Therapies in Rheumatic Diseases (Registro Brasileiro de Monitoração de Terapias Biológicas – BiobadaBrasil). Rev Bras Reumatol Engl Ed. 2017;57 Suppl 2:477-483.

Zarpelon AC, Fattori V, Souto FO, Pinto LG, Pinho-Ribeiro FA, Ruiz-Miyazawa KW, Turato WM, Cunha TM, Da Costa FB, Cunha FQ, Casagrande R, Arakawa NS, Verri WA Jr. Erratum to: The Sesquiterpene Lactone, Budlein A, Inhibits Antigen-Induced Arthritis in Mice: Role of NF-κB and Cytokines. Inflammation. 2017 Sep 6.

Zucoloto AZ, Manchope MF, Staurengo-Ferrari L, Alves-Filho JC, Cunha TM, Antunes MM, Menezes GB, Cunha FQ, Casagrande R, Verri WA Jr. Probucol attenuates overt pain-like behavior and carrageenan-induced inflammatory hyperalgesia and leukocyte recruitment by inhibiting NF-кB activation and cytokine production without antioxidant effects. Inflamm Res. 2017 Jul;66(7):591-602.

Zucoloto AZ, Manchope MF, Staurengo-Ferrari L, Pinho-Ribeiro FA, Zarpelon AC, Saraiva ALL, Cecílio NT, Alves-Filho JC, Cunha TM, Menezes GB, Cunha FQ, Casagrande R, Verri WA Jr. Probucol attenuates lipopolysaccharide-induced leukocyte recruitment and inflammatory hyperalgesia: effect on NF-кB activation and cytokine production. Eur J Pharmacol. 2017 Aug 15;809:52-63.

2016

Alves-Filho JC, Pålsson-McDermott EM. Pyruvate Kinase M2: A Potential Target for Regulating Inflammation. Front Immunol. 2016 Apr 21;7:145.

Alves-Lopes R, Neves KB, Montezano AC, Harvey A, Carneiro FS, Touyz RM, Tostes RC. Internal Pudental Artery Dysfunction in Diabetes Mellitus Is Mediated by NOX1-Derived ROS-, Nrf2-, and Rho Kinase-Dependent Mechanisms. Hypertension. 2016 Oct;68(4):1056-64.

Alves-Lopes R, Neves KB, Silva MA, Olivon VC, Ruginsk SG, Antunes-Rodrigues J, Ramalho LN, Tostes RC, Carneiro FS. Functional and structural changes in internal pudendal arteries underlie erectile dysfunction induced by androgen deprivation. Asian J Androl. 2016 Jul 5.

Bassi GS, do C Malvar D, Cunha TM, Cunha FQ, Kanashiro A. Spinal GABA-B receptor modulates neutrophil recruitment to the knee joint in zymosan-induced arthritis. Naunyn Schmiedebergs Arch Pharmacol. 2016 Aug;389(8):851-61. Doi: 10.1007/s00210-016-1248-0. PubMed PMID: 27106212.

Bertolini TB, de Souza AI, Gembre AF, Piñeros AR, Prado Rde Q, Silva JS, Ramalho LN, Bonato VL. Genetic background affects the expansion of macrophage subsets in the lungs of Mycobacterium tuberculosis-infected hosts. Immunology. 2016 May;148(1):102-13.

Bradley WP, Boyer MA, Nguyen HT, Birdwell LD, Yu J, Ribeiro JM, Weiss SR, Zamboni DS, Roy CR, Shin S. Primary Role for Toll-Like Receptor-Driven Tumor Necrosis Factor Rather than Cytosolic Immune Detection in Restricting Coxiella burnetii Phase II Replication within Mouse Macrophages. Infect Immun. 2016 Mar 24;84(4):998-1015.

Brito MF, Ferreira JV, Souza LR, Gemaque LR, Sousa KP, Santos CF, Braga FS, Pernomian L, Silva CH, Santos CB. Taft CA, Hage-Melim LI. Computational Molecular Modeling of Compounds from Amaryllidaceae Family as Potential Acetylcholinesterase Inhibitors. Current Bioactive Compounds, 2016.

Bruder-Nascimento T, Callera G, Montezano AC, Antunes TT, He Y, Cat AN, Ferreira NS, Barreto PA, Olivon VC, Tostes RC, Touyz RM. Renoprotective Effects of Atorvastatin in Diabetic Mice: Downregulation of RhoA and Upregulation of Akt/GSK3. PLoS One. 2016 Sep 20;11(9):e0162731.

Bruder-Nascimento T, Ferreira NS, Zanotto CZ, Ramalho F, Pequeno IO, Olivon VC, Neves KB, Alves-Lopes R, Campos E, Silva CA, Fazan R, Carlos D, Mestriner FL, Prado D, Pereira FV, Braga T, Luiz JP, Cau SB, Elias PC, Moreira AC, Câmara NO, Zamboni DS, Alves-Filho JC, Tostes RC. NLRP3 Inflammasome Mediates Aldosterone-Induced Vascular Damage. Circulation. 2016 Dec 6;134(23):1866-1880.

Bueno-Silva B, Franchin M, Alves CF, Denny C, Colón DF, Cunha TM, Alencar SM, Napimoga MH, Rosalen PL. Main pathways of action of Brazilian red propolis on the modulation of neutrophils migration in the inflammatory process. Phytomedicine. 2016 Dec 1;23(13):1583-1590.

Caliari-Oliveira C, Yaochite JN, Ramalho LN, Palma PV, Carlos D, Cunha Fde Q, De Souza DA, Frade MA, Covas DT, Malmegrim KC, Oliveira MC, Voltarelli JC. Xenogeneic Mesenchymal Stromal Cells Improve Wound Healing and Modulate the Immune Response in an Extensive Burn Model. Cell Transplant. 2016;25(2):201-15.

Carregaro V, Napimoga MH, Peres RS, Benevides L, Sacramento LA, Pinto LG, Grespan R, Cunha TM, da Silva JS, Cunha FQ. Therapeutic Treatment of Arthritic Mice with 15-Deoxy Δ(12,14)-Prostaglandin J(2) (15d-PGJ(2)) Ameliorates Disease through the Suppression of Th17 Cells and the Induction of CD4(+)CD25(-)FOXP3(+) Cells. Mediators Inflamm. 2016.

Carvalho H, Laurindo I, Ranza R, Titton D, Bertolo M, Bianchi W, Brenol C, Castelar G, Castro G, Costa I, Duarte A, Fernandes V, Freire M, Louzada P, Macieira J, Miranda J, Moraes J, Pereira I, Sauma M, Stadler B, Toledo R, Valim V, Baaklini C. SAT0586-Herpes Zoster in The Brazilian Register. Annals of the Rheumatic Diseases. 2016;75:881.3-882.

Cavalcanti CA, Silva Jde A, Pita Wde B, Veit TD, Monticielo OA, Xavier RM, Brenol JC, Brenol CV, Fragoso TS, Barbosa AD, Duarte ÂL, Oliveira RD, Louzada-Júnior P, Donadi EA, Crovella S, Chies JA, Sandrin-Garcia P. Vitamin D receptor polymorphisms and expression profile in rheumatoid arthritis Brazilian patients. Mol Biol Rep. 2016 Jan;43(1):41-51.

Chaves de Souza JA, Frasnelli SC, Curylofo-Zotti FA, Ávila-Campos MJ, Spolidório LC, Zamboni DS, Graves DT, Rossa C Jr. NOD1 in the modulation of host-microbe interactions and inflammatory bone resorption in the periodontal disease model. Immunology. 2016 Dec;149(4):374-385.

Costa DL, Lima-Júnior DS, Nascimento MS, Sacramento LA, Almeida RP, Carregaro V, Silva JS. CCR2 signaling contributes to the differentiation of protective inflammatory dendritic cells in Leishmania braziliensis infection. J Leukoc Biol. 2016 Aug;100(2):423-32.

Costa FR, Françozo MC, de Oliveira GG, Ignacio A, Castoldi A, Zamboni DS, Ramos SG, Câmara NO, de Zoete MR, Palm NW, Flavell RA, Silva JS, Carlos D. Gut microbiota translocation to the pancreatic lymph nodes triggers NOD2 activation and contributes to T1D onset. J Exp Med. 2016 Jun 27;213(7):1223-39.

Costa FR, Mota CM, Santiago FM, Silva MV, Ferreira MD, Fonseca DM, Silva JS, Mineo JR, Mineo TW. GITR Activation Positively Regulates Immune Responses against Toxoplasma gondii. PLoS One. 2016 Mar 30;11(3):e0152622.

Costa RM, Filgueira FP, Tostes RC, Carvalho MH, Akamine EH, Lobato NS. H2O2 generated from mitochondrial electron transport chain in thoracic perivascular adipose tissue is crucial for modulation of vascular smooth muscle contraction. Vascul Pharmacol. 2016 Sep;84:28-37.

Cunha MG, Franchin M, Paula-Eduardo LF, Freires IA, Beutler JA, Alencar SM, Ikegaki M, CP Tabchoury, Cunha TM, Rosalen PL. Anti-inflammatory and anti-biofilm properties of ent-nemorosone from Brazilian geopropolis. Journal of Functional Foods. 2016 Oct;26:27-35. Doi: 10.1016/j.jff.2016.07.009.

Czaikoski PG, Mota JM, Nascimento DC, Sônego F, Castanheira FV, Melo PH, Scortegagna GT, Silva RL, Barroso-Sousa R, Souto FO, Pazin-Filho A, Figueiredo F, Alves-Filho JC, Cunha FQ. Neutrophil Extracellular Traps Induce Organ Damage during Experimental and Clinical Sepsis. PLoS One. 2016 Feb 5;11(2):e0148142.

da Costa RM, Fais RS, Dechandt CR, Louzada-Junior P, Alberici LC, Lobato NS, Tostes RC. Increased mitochondrial ROS generation mediates the loss of PVAT anticontractile effect in HFD-treated obese mice. Br J Pharmacol. 2016 Dec 8.

da Costa RM, Neves KB, Mestriner FL, Louzada-Junior P, Bruder-Nascimento T, Tostes RC. TNF-α induces vascular insulin resistance via positive modulation of PTEN and decreased Akt/eNOS/NO signaling in high fat diet-fed mice. Cardiovasc Diabetol. 2016 Aug 25;15(1):119.

da Silva CH, Taft CA. 3D descriptors calculation and conformational search to investigate potential bioactive conformations, with application in 3D-QSAR and virtual screening in drug design. J Biomol Struct Dyn. 2016 Oct 14:1-9.

da Silva Dias IC, Carabelli B, Ishii DK, de Morais H, de Carvalho MC, Rizzo de Souza LE, Zanata SM, Brandão ML, Cunha TM, Ferraz AC, Cunha JM, Zanoveli JM. Indoleamine-2,3-Dioxygenase/Kynurenine Pathway as a Potential Pharmacological Target to Treat Depression Associated with Diabetes. Mol Neurobiol. 2016 Dec;53(10):6997-7009.

David BA, Rezende RM, Antunes MM, Santos MM, Freitas Lopes MA, Diniz AB, Sousa Pereira RV, Marchesi SC, Alvarenga DM, Nakagaki BN, Araújo AM, Dos Reis DS, Rocha RM, Marques PE, Lee WY, Deniset J, Liew PX, Rubino S, Cox L, Pinho V, Cunha TM, Fernandes GR, Oliveira AG, Teixeira MM, Kubes P, Menezes GB. Combination of Mass Cytometry and Imaging Analysis Reveals Origin, Location, and Functional Repopulation of Liver Myeloid Cells in Mice. Gastroenterology. 2016 Dec;151(6):1176-1191.

Davoli-Ferreira M, Fonseca DM, Mota CM, Dias MS, Lima-Junior DS, da Silva MV, Quirino GF, Zamboni DS, Silva JS, Mineo TW. Nucleotide-binding oligomerization domain-containing protein 2 prompts potent inflammatory stimuli during Neospora caninum infection. Sci Rep. 2016 Jul 5;6:29289.

de Molon RS, Hsu C, Bezouglaia O, Dry SM, Pirih FQ, Soundia A, Cunha FQ, Cirelli JA, Aghaloo TL, Tetradis S. Rheumatoid Arthritis Exacerbates the Severity of Osteonecrosis of the Jaws (ONJ) in Mice. A Randomized, Prospective, Controlled Animal Study. J Bone Miner Res. 2016 Aug;31(8):1596-607.

de Oliveira LF, Romano MM, de Carvalho EE, Cabeza JM, Salgado HC, Fazan Júnior R, Costa RS, da Silva JS, Higuchi Mde L, Maciel BC, Cunha-Neto E, Marin-Neto JA, Simões MV. Histopathological Correlates of Global and Segmental Left Ventricular Systolic Dysfunction in Experimental Chronic Chagas Cardiomyopathy. J Am Heart Assoc. 2016 Jan 21;5(1).

de Oliveira LM, de Oliveira TS, da Costa RM, de Souza Gil E, Costa EA, Passaglia Rde C, Filgueira FP, Ghedini PC. The vasorelaxant effect of gallic acid involves endothelium-dependent and -independent mechanisms. Vascul Pharmacol. 2016 Jun;81:69-74.

de Paula Costa G, Lopes LR, da Silva MC, Horta AL, Pontes WM, Milanezi CM, Guedes PM, de Lima WG, Schulz R, da Silva JS, Talvani A. Doxycycline and Benznidazole Reduce the Profile of Th1, Th2, and Th17 Chemokines and Chemokine Receptors in Cardiac Tissue from Chronic Trypanosoma cruzi-Infected Dogs. Mediators Inflamm. 2016.

Dias-Teixeira KL, Pereira RM, Silva JS, Fasel N, Aktas BH, Lopes UG. Unveiling the Role of the Integrated Endoplasmic Reticulum Stress Response in Leishmania Infection – Future Perspectives. Front Immunol. 2016 Jul 22;7:283.

Diniz EM, Poiani JG, Taft CA, Silva CH. Structure-based drug design, molecular dynamics and ADME/Tox to investigate protein kinase anti-cancer agents. Current Bioactive Compounds, 2016.

Diniz EM, Tomich de Paula da Silva CH, Gómez-Perez V, Federico LB, Campos Rosa JM. GRIND2-based 3D-QSAR and prediction of activity spectra for symmetrical bis-pyridinium salts with promastigote antileishmanial activity. J Biomol Struct Dyn. 2016 Sep 6:1-11.

Dos Santos Picanço LC, Ozela PF, de Fátima de Brito Brito M, Pinheiro AA, Padilha EC, Braga FS, de Paula da Silva CH, Dos Santos CB, Rosa JM, da Silva Hage-Melim LI. Alzheimer’s disease: A review from the pathophysiology to diagnosis, new perspectives for pharmacological treatment. Curr Med Chem. 2016 Dec 12.

Ellebedy AH, Jackson KJ, Kissick HT, Nakaya HI, Davis CW, Roskin KM, McElroy AK, Oshansky CM, Elbein R, Thomas S, Lyon GM, Spiropoulou CF, Mehta AK, Thomas PG, Boyd SD, Ahmed R. Defining antigen-specific plasmablast and memory B cell subsets in human blood after viral infection or vaccination. Nat Immunol. 2016 Oct;17(10):1226-34.

Falcão J, Valim V, Titton D, Ranza R, Carvalho H, Bianchi W, Stadler B, Fernandes V, Louzada P, Bertolo M, Duarte A, Macieira J, Miranda J, Castelar G, Freire M, Toledo R, Moraes J, Costa I, Pereira I, Sauma M, Castro G, Brenol C, Zandonade E, Laurindo I, Baaklini C. FRI0195-Switching from anti-TNF To Non anti-TNF Therapy Yield Better Survival in Rheumatoid Arthritis (RA): Results from Brazilian Register of Biological Agents in Rheumatic Diseases. Annals of the Rheumatic Diseases. 2016; 75:501.1-501.

Fattori V, Pinho-Ribeiro FA, Borghi SM, Alves-Filho JC, Cunha TM, Cunha FQ, Casagrande R, Verri WA Jr. Curcumin inhibits superoxide anion-induced pain-like behavior and leukocyte recruitment by increasing Nrf2 expression and reducing NF-κB activation. Inflamm Res. 2015 Dec;64(12):993-1003.

Federico LB, Almeida JR, Taft CA, Silva CH. Ligand and Structure-Based Drug Design as Strategies for the Screening of New BACE1 Inhibitor Candidates. Current Physical Chemistry, 2016.

Federico LB, Santos CB, Lobato CC, Gomes JS, Rosa JC, Silva CH. 3D descriptors calculation and conformational search to investigate potential bioactive conformations, with application in 3D-QSAR. Journal of Computational and Theoretical Nanoscience, 2016.

Fernandes TD, Cunha LD, Ribeiro JM, Massis LM, Lima-Junior DS, Newton HJ, Zamboni DS. Murine Alveolar Macrophages Are Highly Susceptible to Replication of Coxiella burnetii Phase II In Vitro. Infect Immun. 2016 Aug 19;84(9):2439-48.

Figueredo AS, Oliveira MG, Safadi GM, Silva CH, Silva VB, Aquino GL. The Natural Alkaloid Piperine and its Acid and Ester Synthetic Derivatives are Acetylcholinesterase Inhibitors. Current Physical Chemistry, 2016.

Franca RF, Costa RS, Silva JR, Peres RS, Mendonça LR, Colón DF, Alves-Filho JC, Cunha FQ. IL-33 signaling is essential to attenuate viral-induced encephalitis development by downregulating iNOS expression in the central nervous system. J Neuroinflammation. 2016 Jun 22;13(1):159.

Franchin M, Cólon DF, Castanheira FV, da Cunha MG, Bueno-Silva B, Alencar SM, Cunha TM, Rosalen PL. Vestitol Isolated from Brazilian Red Propolis Inhibits Neutrophils Migration in the Inflammatory Process: Elucidation of the Mechanism of Action. J Nat Prod. 2016 Apr 22;79(4):954-60.

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Santa-Cecília FV, Socias B, Ouidja MO, Sepulveda-Diaz JE, Acuña L, Silva RL, Michel PP, Del-Bel E, Cunha TM, Raisman-Vozari R. Doxycycline Suppresses Microglial Activation by Inhibiting the p38 MAPK and NF-kB Signaling Pathways. Neurotox Res. 2016 May;29(4):447-59.

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Veras FP, Peres RS, Saraiva AL, Pinto LG, Louzada-Junior P, Cunha TM, Paschoal JA, Cunha FQ, Alves-Filho JC. Fructose 1,6-bisphosphate, a high-energy intermediate of glycolysis, attenuates experimental arthritis by activating anti-inflammatory adenosinergic pathway. Sci Rep. 2015 Oct 19;5:15171.

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