Alves-Lopes RU, Neves KB, Silva MA, Olivon VC, Ruginsk SG, Antunes-Rodrigues J, Ramalho LN, Tostes RC, Carneiro FS. Functional and structural changes in internal pudendal arteries underlie erectile dysfunction induced by androgen deprivation. Asian J Androl. 2017 Sep-Oct;19(5):526-532.

Anatriello E, Oliveira CJF, Oliveira NB, Fisch A, Milanezi CM, da Silva JS, de Miranda-Santos IKF, Ferreira BR. Interaction between saliva’s adenosine and tick parasitism: effects on feeding and reproduction. Parasit Vectors. 2017 Jul 10;10(1):326.

Andrade WA, Zamboni DS. Inflammasome-dependent Mechanisms Involved in Sensing and Restriction of Bacterial Replication. Curr Issues Mol Biol. 2017 Sep 6;25:99-132. doi: 10.21775/cimb.025.099. [Epub ahead of print] PubMed PMID: 28875942.

Bassi GS, Dias DPM, Franchin M, Talbot J, Reis DG, Menezes GB, Castania JA, Garcia-Cairasco N, Resstel LBM, Salgado HC, Cunha FQ, Cunha TM, Ulloa L, Kanashiro A. Modulation of experimental arthritis by vagal sensory and central brain stimulation. Brain Behav Immun. 2017 Aug;64:330-343.

Becari C, Silva MAB, Durand MT, Prado CM, Oliveira EB, Ribeiro MS, Salgado HC, Salgado MCO, Tostes RC. Elastase-2, an angiotensin II-generating enzyme, contributes to increased angiotensin II in resistance arteries of mice with myocardial infarction. Br J Pharmacol. 2017 May;174(10):1104-1115.

Bertozzi MM, Rossaneis AC, Fattori V, Longhi-Balbinot DT, Freitas A, Cunha FQ, Alves-Filho JC, Cunha TM, Casagrande R, Verri WA Jr. Diosmin reduces chronic constriction injury-induced neuropathic pain in mice. Chem Biol Interact. 2017 Aug 1;273:180-189.

Braga TT, Correa-Costa M, Silva RC, Cruz MC, Hiyane MI, da Silva JS, Perez KR, Cuccovia IM, Camara NO. CCR2 contributes to the recruitment of monocytes and leads to kidney inflammation and fibrosis development. Inflammopharmacology. 2017 Feb 6.

BRITO MFB, FERREIRA JV, SOUZA LR, GEMAQUE LR, SOUSA KP, SANTOS CF, BRAGA FS, PERNOMIAN L, SILVA CHTP, SANTOS CBR, TAFT CA, HAGE-MELIM LI. Computational Molecular Modeling of Compounds from Amaryllidaceae Family as Potential Acetylcholinesterase Inhibitors. CURRENT BIOACTIVE COMPOUNDS, v. 13, p. 121-129, 2017.

Carlos D, Costa FR, Pereira CA, Rocha FA, Yaochite JN, Oliveira GG, Carneiro FS, Tostes RC, Ramos SG, Zamboni DS, Camara NO, Ryffel B, Silva JS. Mitochondrial DNA Activates the NLRP3 Inflammasome and Predisposes to Type 1 Diabetes in Murine Model. Front Immunol. 2017 Feb 27;8:164.

Chen W, Foo SS, Zaid A, Teng TS, Herrero LJ, Wolf S, Tharmarajah K, Vu LD, van Vreden C, Taylor A, Freitas JR, Li RW, Woodruff TM, Gordon R, Ojcius DM, Nakaya HI, Kanneganti TD, O’Neill LAJ, Robertson AAB, King NJ, Suhrbier A, Cooper MA, Ng LFP, Mahalingam S. Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammation. Nat Microbiol. 2017 Aug 28.

Côco H, Pernomian L, Pereira PC, Gomes MS, Marchi KC, Lopes AH, Cunha TM, Tirapelli CR, de Oliveira AM. Chronic restraint stress increases angiotensin II potency in the rat carotid: role of cyclooxygenases and reactive oxygen species. J Pharm Pharmacol. 2017 Jan;69(1):52-65.

Costa JDS, Costa KDSL, Cruz JV, Ramosb RDS, Silva LB, Barros Brasilc DDS, Henrique Tomich de Paula da Silva C, Santos CBRD, Macêdoe WJDC. Virtual screening and statistical analysis in the design of new caffeine analogues molecules with potential epithelial anticancer activity. Curr Pharm Des. 2017 Jul 11.

Costa VV, Del Sarto JL, Rocha RF, Silva FR, Doria JG, Olmo IG, Marques RE, Queiroz-Junior CM, Foureaux G, Araújo JMS, Cramer A, Real ALCV, Ribeiro LS, Sardi SI, Ferreira AJ, Machado FS, de Oliveira AC, Teixeira AL, Nakaya HI, Souza DG, Ribeiro FM, Teixeira MM. N-Methyl-d-Aspartate (NMDA) Receptor Blockade Prevents Neuronal Death Induced by Zika Virus Infection. MBio. 2017 Apr 25;8(2). pii: e00350-17.

Cunha LD, Silva ALN, Ribeiro JM, Mascarenhas DPA, Quirino GFS, Santos LL, Flavell RA, Zamboni DS. AIM2 Engages Active but Unprocessed Caspase-1 to Induce Noncanonical Activation of the NLRP3 Inflammasome. Cell Rep. 2017 Jul 25;20(4):794-805.

da Costa RM, Fais RS, Dechandt CRP, Louzada-Junior P, Alberici LC, Lobato NS, Tostes RC. Increased mitochondrial ROS generation mediates the loss of the anti-contractile effects of perivascular adipose tissue in high-fat diet obese mice. Br J Pharmacol. 2017 Oct;174(20):3527-3541.

da Silva CHTP, Taft CA. 3D descriptors calculation and conformational search to investigate potential bioactive conformations, with application in 3D-QSAR and virtual screening in drug design. J Biomol Struct Dyn. 2017 Oct;35(13):2966-2974.

Dal-Secco D, DalBó S, Lautherbach NES, Gava FN, Celes MRN, Benedet PO, Souza AH, Akinaga J, Lima V, Silva KP, Kiguti LRA, Rossi MA, Kettelhut IC, Pupo AS, Cunha FQ, Assreuy J. Cardiac hyporesponsiveness in severe sepsis is associated with nitric oxide-dependent activation of G protein receptor kinase. Am J Physiol Heart Circ Physiol. 2017 Jul 1;313(1):H149-H163.

Dalto VF, Assad RL, Crema MD, Louzada-Junior P, Nogueira-Barbosa MH. MRI assessment of bone marrow oedema in the sacroiliac joints of patients with spondyloarthritis: is the SPAIR T2w technique comparable to STIR? Eur Radiol. 2017 Sep;27(9):3669-3676.

de Aquino SG, Talbot J, Sônego F, Turato WM, Grespan R, Avila-Campos MJ, Cunha FQ, Cirelli JA. The aggravation of arthritis by periodontitis is dependent of IL-17 receptor A activation. J Clin Periodontol. 2017 Sep;44(9):881-891.

de Carvalho LM, Ngoumou G, Park JW, Ehmke N, Deigendesch N, Kitabayashi N, Melki I, Souza FFL, Tzschach A, Nogueira-Barbosa MH, Ferriani V, Louzada-Junior P, Marques W Jr, Lourenço CM, Horn D, Kallinich T, Stenzel W, Hur S, Rice GI, Crow YJ. Musculoskeletal Disease in MDA5-Related Type I Interferonopathy: A Mendelian Mimic of Jaccoud’s Arthropathy. Arthritis Rheumatol. 2017 Oct;69(10):2081-2091.

de Oliveira CE, Gasparoto TH, Pinheiro CR, Amôr NG, Nogueira MRS, Kaneno R, Garlet GP, Lara VS, da Silva JS, Cavassani KA, Campanelli AP. CCR5-dependent homing of T regulatory cells to the tumor microenvironment contributes to skin squamous cell carcinoma development. Mol Cancer Ther. 2017 Sep 13. Pii: molcanther.0341.2017.

de Oliveira LSS, de Araújo AA, de Araújo Júnior RF, Barboza CAG, Borges BCD, da Silva JSP. Low-level laser therapy (780 nm) combined with collagen sponge scaffold promotes repair of rat cranial critical-size defects and increases TGF-β, FGF-2, OPG/RANK and osteocalcin expression. Int J Exp Pathol. 2017 May 29.

Dela Justina V, Gonçalves JS, de Freitas RA, Fonseca AD, Volpato GT, Tostes RC, Carneiro FS, Lima VV, Giachini FR. Increased O-Linked N-Acetylglucosamine Modification of NF-ΚB and Augmented Cytokine Production in the Placentas from Hyperglycemic Rats. Inflammation. 2017 Jul 8.

Dias RG, Sampaio SC, Sant’Anna MB, Cunha FQ, Gutiérrez JM, Lomonte B, Cury Y, Picolo G. Articular inflammation induced by an enzymatically-inactive Lys49 phospholipase A(2): activation of endogenous phospholipases contributes to the pronociceptive effect. J Venom Anim Toxins Incl Trop Dis. 2017 Mar 23;23:18.

DINIZ EMLP, POIANI JGC, TAFT CA, SILVA CHTP. Structure-based drug design, molecular dynamics and ADME/Tox to investigate protein kinase anti-cancer agents. CURRENT BIOACTIVE COMPOUNDS, v. 13, p. yy-yyy, 2017.

Diniz EMLP, Tomich de Paula da Silva CH, Gómez-Perez V, Federico LB, Campos Rosa JM. GRIND2-based 3D-QSAR and prediction of activity spectra for symmetrical bis-pyridinium salts with promastigote antileishmanial activity. J Biomol Struct Dyn. 2017 Aug;35(11):2430-2440.

Eugenia Schroeder M, Russo S, Costa C, Hori J, Tiscornia I, Bollati-Fogolín M, Zamboni DS, Ferreira G, Cairoli E, Hill M. Pro-inflammatory Ca(++)-activated K(+) channels are inhibited by hydroxychloroquine. Sci Rep. 2017 May 15;7(1):1892.

Fattori V, Serafim KG, Zarpelon AC, Borghi SM, Pinho-Ribeiro FA, Alves-Filho JC, Cunha TM, Cunha FQ, Casagrande R, Verri WA Jr. Differential regulation of oxidative stress and cytokine production by endothelin ET(A) and ET(B) receptors in superoxide anion-induced inflammation and pain in mice. J Drug Target. 2017 Mar;25(3):264-274.

Feriotti C, de Araújo EF, Loures FV, da Costa TA, Galdino NAL, Zamboni DS, Calich VLG. NOD-Like Receptor P3 Inflammasome Controls Protective Th1/Th17 Immunity against Pulmonary Paracoccidioidomycosis. Front Immunol. 2017 Jul 10;8:786.

Ferreira JV, Chaves GA, Marino BLB, Sousa KPA, Souza LR, Brito MFB, Teixeira HRC, da Silva CHTP, Santos CBR, Hage-Melim LIS. Cannabinoid Type 1 Receptor (CB1) Ligands with Therapeutic Potential for Withdrawal Syndrome in Chemical Dependents of Cannabis sativa. ChemMedChem. 2017 Aug 22;12(16):1408-1416.

Ferreira LR, Ferreira FM, Nakaya HI, Deng X, Cândido DD, de Oliveira LC, Billaud JN, Lanteri MC, Rigaud VO, Seielstad M, Kalil J, Fernandes F, Ribeiro AL, Sabino EC, Cunha-Neto E. Blood Gene Signatures of Chagas Cardiomyopathy With or Without Ventricular Dysfunction. J Infect Dis. 2017 Feb 1;215(3):387-395.

Franco LH, Fleuri AKA, Pellison NC, Quirino GFS, Horta CV, de Carvalho RVH, Oliveira SC, Zamboni DS. Autophagy downstream of endosomal Toll-like receptor signaling in macrophages is a key mechanism for resistance to Leishmania major infection. J Biol Chem. 2017 Aug 11;292(32):13087-13096.

Geraldo MV, Nakaya HI, Kimura ET. Down-regulation of 14q32-encoded miRNAs and tumor suppressor role for miR-654-3p in papillary thyroid cancer. Oncotarget. 2017 Feb 7;8(6):9597-9607.

Gonçalves AC, Ferreira LS, Manente FA, de Faria CMQG, Polesi MC, de Andrade CR, Zamboni DS, Carlos IZ. The NLRP3 inflammasome contributes to host protection during Sporothrix schenckii infection. Immunology. 2017 Jun;151(2):154-166.

Guimarães FR, Sales-Campos H, Nardini V, da Costa TA, Fonseca MTC, Júnior VR, Sorgi CA, da Silva JS, Chica JEL, Faccioli LH, de Barros Cardoso CR. The inhibition of 5-lipoxygenase (5-LO) products leukotriene B4 (LTB(4)) and cysteinyl leukotrienes (cysLTs) modulates the inflammatory response and improves cutaneous wound healing. Clin Immunol. 2017 Sep 28. pii: S1521-6616(16)30576-9.

Kanashiro A, Sônego F, Ferreira RG, Castanheira FV, Leite CA, Borges VF, Nascimento DC, Cólon DF, Alves-Filho JC, Ulloa L, Cunha FQ. Therapeutic potential and limitations of cholinergic anti-inflammatory pathway in sepsis. Pharmacol Res. 2017 Mar;117:1-8.

Kasturi SP, Kozlowski PA, Nakaya HI, Burger MC, Russo P, Pham M, Kovalenkov Y, Silveira EL, Havenar-Daughton C, Burton SL, Kilgore KM, Johnson MJ, Nabi R, Legere T, Sher ZJ, Chen X, Amara RR, Hunter E, Bosinger SE, Spearman P, Crotty S, Villinger F, Derdeyn CA, Wrammert J, Pulendran B. Adjuvanting a Simian Immunodeficiency Virus Vaccine with Toll-Like Receptor Ligands Encapsulated in Nanoparticles Induces Persistent Antibody Responses and Enhanced Protection in TRIM5α Restrictive Macaques. J Virol. 2017 Jan 31;91(4). pii: e01844-16.

Kazmin D, Nakaya HI, Lee EK, Johnson MJ, van der Most R, van den Berg RA, Ballou WR, Jongert E, Wille-Reece U, Ockenhouse C, Aderem A, Zak DE, Sadoff J, Hendriks J, Wrammert J, Ahmed R, Pulendran B. Systems analysis of protective immune responses to RTS,S malaria vaccination in humans. Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):2425-2430.

Khalid KE, Nascimento MSL, Sacramento LA, Costa DL, Lima-Júnior DS, Carregaro V, da Silva JS. T1/ST2 deficient mice display protection against Leishmania infantum experimental infection. Acta Trop. 2017 Aug;172:1-6.

Lever M, Silveira EL, Nakaya HI. Systems Vaccinology Applied to DNA Vaccines: Perspective and Challenges. Curr Issues Mol Biol. 2017;22:1-16. Review. PubMed PMID: 27648510.

Li S, Sullivan NL, Rouphael N, Yu T, Banton S, Maddur MS, McCausland M, Chiu C, Canniff J, Dubey S, Liu K, Tran V, Hagan T, Duraisingham S, Wieland A, Mehta AK, Whitaker JA, Subramaniam S, Jones DP, Sette A, Vora K, Weinberg A, Mulligan MJ, Nakaya HI, Levin M, Ahmed R, Pulendran B. Metabolic Phenotypes of Response to Vaccination in Humans. Cell. 2017 May 18;169(5):862-877.e17.

Lima MHF, Sacramento LA, Quirino GFS, Ferreira MD, Benevides L, Santana AKM, Cunha FQ, Almeida RP, Silva JS, Carregaro V. Leishmania infantum Parasites Subvert the Host Inflammatory Response through the Adenosine A2(A) Receptor to Promote the Establishment of Infection. Front Immunol. 2017 Jul 20;8:815.

Lima-Junior DS, Mineo TWP, Calich VLG, Zamboni DS. Dectin-1 Activation during Leishmania amazonensis Phagocytosis Prompts Syk-Dependent Reactive Oxygen Species Production To Trigger Inflammasome Assembly and Restriction of Parasite Replication. J Immunol. 2017 Sep 15;199(6):2055-2068.

Lucetti LT, Silva RO, Santana AP, de Melo Tavares B, Vale ML, Soares PM, de Lima Júnior FJ, Magalhães PJ, de Queiroz Cunha F, de Albuquerque Ribeiro R, Medeiros JR, Souza MH. Nitric Oxide and Hydrogen Sulfide Interact When Modulating Gastric Physiological Functions in Rodents. Dig Dis Sci. 2017 Jan;62(1):93-104.

Madeira MFM, Queiroz Junior CM, Corrêa JD, Werneck SMC, Machado FS, Cunha TM, Garlet GP, Teixeira MM, da Silva TA, Souza DG. The role of 5-lipoxygenase in Aggregatibacter actinomycetemcomitans-induced alveolar bone loss. J Clin Periodontol. 2017 Jun 1.

Maia PI, Carneiro ZA, Lopes CD, Oliveira CG, Silva JS, de Albuquerque S, Hagenbach A, Gust R, Deflon VM, Abram U. Organometallic gold(iii) complexes withhybrid SNS-donating thiosemicarbazone ligands: cytotoxicity and anti-Trypanosoma cruzi activity. Dalton Trans. 2017 Feb 21;46(8):2559-2571.

Martelli-Palomino G, Paoliello-Paschoalato AB, Crispim JC, Rassi DM, Oliveira RD, Louzada P, Lucisano-Valim YM, Donadi EA. DNA damage increase in peripheral neutrophils from patients with rheumatoid arthritis is associated with the disease activity and the presence of shared epitope. Clin Exp Rheumatol. 2017 Mar-Apr;35(2):247-254.

Mascarenhas DP, Zamboni DS. Inflammasome biology taught by Legionella pneumophila. J Leukoc Biol. 2017 Apr;101(4):841-849.

Mascarenhas DPA, Cerqueira DM, Pereira MSF, Castanheira FVS, Fernandes TD, Manin GZ, Cunha LD, Zamboni DS. Inhibition of caspase-1 or gasdermin-D enable caspase-8 activation in the Naip5/NLRC4/ASC inflammasome. PLoS Pathog. 2017 Aug 3;13(8):e1006502.

Massis LM, Assis-Marques MA, Castanheira FV, Capobianco YJ, Balestra AC, Escoll P, Wood RE, Manin GZ, Correa VM, Alves-Filho JC, Cunha FQ, Buchrieser C, Borges MC, Newton HJ, Zamboni DS. Legionella longbeachae Is Immunologically Silent and Highly Virulent In Vivo. J Infect Dis. 2017 Feb 1;215(3):440-451.

Nascimento DC, Melo PH, Piñeros AR, Ferreira RG, Colón DF, Donate PB, Castanheira FV, Gozzi A, Czaikoski PG, Niedbala W, Borges MC, Zamboni DS, Liew FY, Cunha FQ, Alves-Filho JC. IL-33 contributes to sepsis-induced long-term immunosuppression by expanding the regulatory T cell population. Nat Commun. 2017 Apr 4;8:14919.

Oliveira AC, Gomes-Neto JF, Barbosa CD, Granato A, Reis BS, Santos BM, Fucs R, Canto FB, Nakaya HI, Nóbrega A, Bellio M. Crucial role for T cell-intrinsic IL-18R-MyD88 signaling in cognate immune response to intracellular parasite infection. Elife. 2017 Sep 12;6. pii: e30883.

Oliveira ÉA, Lima DS, Cardozo LE, Souza GF, de Souza N, Alves-Fernandes DK, Faião-Flores F, Quincoces JAP, Barros SBM, Nakaya HI, Monteiro G, Maria-Engler SS. Toxicogenomic and bioinformatics platforms to identify key molecular mechanisms of a curcumin-analogue DM-1 toxicity in melanoma cells. Pharmacol Res. 2017 Nov;125(Pt B):178-187.

Parente JM, Pereira CA, Oliveira-Paula GH, Tanus-Santos JE, Tostes RC, Castro MM. Matrix Metalloproteinase-2 Activity is Associated with Divergent Regulation of Calponin-1 in Conductance and Resistance Arteries in Hypertension-induced Early Vascular Dysfunction and Remodelling. Basic Clin Pharmacol Toxicol. 2017 Oct;121(4):246-256.

Pereira AL, Dos Santos GB, Franco MS, Federico LB, da Silva CH, Santos CB. Molecular modeling and statistical analysis in the design of derivatives of human dipeptidyl peptidase IV. J Biomol Struct Dyn. 2017 Jan 24:1-17.

Pereira CA, Rodrigues FL, Ruginsk SG, Zanotto CZ, Rodrigues JA, Duarte DA, Costa-Neto CM, Resstel LB, Carneiro FS, Tostes RC. Chronic treatment with fluoxetine modulates vascular adrenergic responses by inhibition of pre- and post-synaptic mechanisms. Eur J Pharmacol. 2017 Apr 5;800:70-80.

Peres RS, Santos GB, Cecilio NT, Jabor VA, Niehues M, Torres BG, Buqui G, Silva CH, Costa TD, Lopes NP, Nonato MC, Ramalho FS, Louzada-Júnior P, Cunha TM, Cunha FQ, Emery FS, Alves-Filho JC. Lapachol, a compound targeting pyrimidine metabolism, ameliorates experimental autoimmune arthritis. Arthritis Res Ther. 2017 Mar 7;19(1):47.

Pernomian L, Gomes MS, Moreira JD, da Silva CHTP, Rosa JMC, Cardoso CRB. New Horizons on Molecular Pharmacology Applied to Drug Discovery: When Resonance Overcomes Radioligand Binding. Curr Radiopharm. 2017;10(1):16-20.

Piñeros Alvarez AR, Glosson-Byers N, Brandt S, Wang S, Wong H, Sturgeon S, McCarthy BP, Territo PR, Alves-Filho JC, Serezani CH. SOCS1 is a negative regulator of metabolic reprogramming during sepsis. JCI Insight. 2017 Jul 6;2(13). pii: 92530.

Piñeros AR, Campos LW, Fonseca DM, Bertolini TB, Gembre AF, Prado RQ, Alves-Filho JC, Ramos SG, Russo M, Bonato VL. M2 macrophages or IL-33 treatment attenuate ongoing Mycobacterium tuberculosis infection. Sci Rep. 2017 Jan 27;7:41240.

Prada-Medina CA, Fukutani KF, Pavan Kumar N, Gil-Santana L, Babu S, Lichtenstein F, West K, Sivakumar S, Menon PA, Viswanathan V, Andrade BB, Nakaya HI, Kornfeld H. Systems Immunology of Diabetes-Tuberculosis Comorbidity Reveals Signatures of Disease Complications. Sci Rep. 2017 May 17;7(1):1999.

Racioppi L, Lento W, Huang W, Arvai S, Doan PL, Harris JR, Marcon F, Nakaya HI, Liu Y, Chao N. Calcium/calmodulin-dependent kinase kinase 2 regulates hematopoietic stem and progenitor cell regeneration. Cell Death Dis. 2017 Oct 5;8(10):e3076.

Ramos-Junior ES, Leite GA, Carmo-Silva CC, Taira TM, Neves KB, Colón DF, da Silva LA, Salvador SL, Tostes RC, Cunha FQ, Fukada SY. Adipokine Chemerin Bridges Metabolic Dyslipidemia and Alveolar Bone Loss in Mice. J Bone Miner Res. 2017 May;32(5):974-984.

Rezende BM, Athayde RM, Gonçalves WA, Resende CB, Teles de Tolêdo Bernardes P, Perez DA, Esper L, Reis AC, Rachid MA, Castor MGME, Cunha TM, Machado FS, Teixeira MM, Pinho V. Inhibition of 5-lipoxygenase alleviates graft-versus-host disease. J Exp Med. 2017 Sep 25. pii: jem.20170261.

Rodrigues FL, Fais RS, Pereira MGAG, Garcia-Cairasco N, Tostes RC, Carneiro FS. Erectile Dysfunction in Wistar Audiogenic Rats Is Associated With Increased Cavernosal Contraction and Decreased Neuronal Nitric Oxide Synthase Protein Expression. Urology. 2017 Aug;106:237.e1-237.e8.

Sacramento LA, da Costa JL, de Lima MH, Sampaio PA, Almeida RP, Cunha FQ, Silva JS, Carregaro V. Toll-Like Receptor 2 Is Required for Inflammatory Process Development during Leishmania infantum Infection. Front Microbiol. 2017 Feb 23;8:262.

Santos MB, de Oliveira DT, Cazzaniga RA, Varjão CS, Dos Santos PL, Santos MLB, Correia CB, Faria DR, Simon MDV, Silva JS, Dutra WO, Reed SG, Duthie MS, de Almeida RP, de Jesus AR. Distinct Roles of Th17 and Th1 Cells in Inflammatory Responses Associated with the Presentation of Paucibacillary Leprosy and Leprosy Reactions. Scand J Immunol. 2017 Jul;86(1):40-49.

Santos-Almeida FM, Domingos-Souza G, Meschiari CA, Fávaro LC, Becari C, Castania JA, Lopes A, Cunha TM, Moraes DJA, Cunha FQ, Ulloa L, Kanashiro A, Tezini GCSV, Salgado HC. Carotid sinus nerve electrical stimulation in conscious rats attenuates systemic inflammation via chemoreceptor activation. Sci Rep. 2017 Jul 24;7(1):6265.

Sesti-Costa R, Françozo MCS, Silva GK, Proenca-Modena JL, Silva JS. TLR3 is required for survival following Coxsackievirus B3 infection by driving T lymphocyte activation and polarization: The role of dendritic cells. PLoS One. 2017 Oct 3;12(10):e0185819.

Silva JR, Lopes AH, Talbot J, Cecilio NT, Rossato MF, Silva RL, Souza GR, Silva CR, Lucas G, Fonseca BA, Arruda E, Alves-Filho JC, Cunha FQ, Cunha TM. Neuroimmune-Glia Interactions in the Sensory Ganglia Account for the Development of Acute Herpetic Neuralgia. J Neurosci. 2017 Jul 5;37(27):6408-6422.

Silva NR, Gomes FV, Fonseca MD, Mechoulam R, Breuer A, Cunha TM, Guimarães FS. Antinociceptive effects of HUF-101, a fluorinated cannabidiol derivative. Prog Neuropsychopharmacol Biol Psychiatry. 2017 Oct 3;79(Pt B):369-377.

Silva RL, Lopes AH, Guimarães RM, Cunha TM. CXCL1/CXCR2 signaling in pathological pain: Role in peripheral and central sensitization. Neurobiol Dis. 2017 Sep;105:109-116.

Simplicio JA, do Vale GT, Gonzaga NA, Leite LN, Hipólito UV, Pereira CA, Tostes RC, Tirapelli CR. Reactive oxygen species derived from NAD(P)H oxidase play a role on ethanol-induced hypertension and endothelial dysfunction in rat resistance arteries. J Physiol Biochem. 2017 Feb;73(1):5-16.

Souza MC, Fonseca DM, Kanashiro A, Benevides L, Medina TS, Dias MS, Andrade WA, Bonfá G, Silva MAB, Gozzi A, Borges MC, Gazzinelli RT, Alves-Filho JC, Cunha  FQ, Silva JS. Chronic Toxoplasma gondii Infection Exacerbates Secondary Polymicrobial Sepsis. Front Cell Infect Microbiol. 2017 Apr 7;7:116.

Souza-Silva L, Alves-Lopes R, Silva Miguez J, Dela Justina V, Neves KB, Mestriner FL, Tostes RC, Giachini FR, Lima VV. Glycosylation with O-Linked β-N-acetylglucosamine (O-GlcNAc) induces vascular dysfunction via production of superoxide anion / reactive oxygen species. Can J Physiol Pharmacol. 2017 Aug 9.

Spirlandeli AL, Dick-de-Paula I, Zamarioli A, Jorgetti V, Ramalho LNZ, Nogueira-Barbosa MH, Volpon JB, Jordão AA, Cunha FQ, Fukada SY, de Paula FJA. Hepatic Osteodystrophy: The Mechanism of Bone Loss in Hepatocellular Disease and the Effects of Pamidronate Treatment. Clinics (Sao Paulo). 2017 Apr;72(4):231-237.

Teixeira LB, Parreiras-E-Silva LT, Bruder-Nascimento T, Duarte DA, Simões SC, Costa RM, Rodríguez DY, Ferreira PAB, Silva CAA, Abrao EP, Oliveira EB, Bouvier M, Tostes RC, Costa-Neto CM. Ang-(1-7) is an endogenous β-arrestin-biased agonist of the AT(1) receptor with protective action in cardiac hypertrophy. Sci Rep. 2017 Sep 19;7(1):11903.

Toson B, Dos Santos EJ, Adelino JE, Sandrin-Garcia P, Crovella S, Louzada-Júnior P, Oliveira RD, Pedroza LS, de Fátima Lobato Cunha Sauma M, de Lima CP, Barbosa FB, Brenol CV, Xavier RM, Chies JA, Veit TD. CCR5Δ32 and the genetic susceptibility to rheumatoid arthritis in admixed populations: a multicentre study. Rheumatology (Oxford). 2017 Mar 1;56(3):495-497.

Trevelin SC, Carlos D, Beretta M, da Silva JS, Cunha FQ. Diabetes Mellitus and Sepsis: A Challenging Association. Shock. 2017 Mar;47(3):276-287.

Wynne BM, Labazi H, Carneiro ZN, Tostes RC, Webb RC. Angeli’s Salt, a nitroxyl anion donor, reverses endothelin-1 mediated vascular dysfunction in murine aorta. Eur J Pharmacol. 2017 Nov 5;814:294-301.

Wynne BM, Labazi H, Tostes RC, Webb RC. Nitroxyl anion mediates relaxation in mesenteric arteries from angiotensin II hypertensive mice. Curr Vasc Pharmacol. 2017 Jul 25.

Yonekura CL, Oliveira RDR, Titton DC, Ranza R, Ranzolin A, Hayata AL, Duarte Â, Silveira IG, Carvalho HMDS, Moraes JCB, Abreu MM, Valim V, Bianchi W, Brenol CV, Pereira IA, Costa I, Macieira JC, Miranda JRS, Guedes-Barbosa LS, Bertolo MB, Sauma MFLDC, Silva MBG, Freire M, Scheinberg MA, Toledo RA, Oliveira SKF, Fernandes V, Pinheiro MM, Castro G, Vieira WP, Baaklini CE, Ruffino-Netto A, Pinheiro GDRC, Laurindo IMM, Louzada-Junior P. Incidence of tuberculosis among patients with rheumatoid arthritis using TNF blockers in Brazil: data from the Brazilian Registry of Biological Therapies in Rheumatic Diseases (Registro Brasileiro de Monitoração de Terapias Biológicas – BiobadaBrasil). Rev Bras Reumatol Engl Ed. 2017;57 Suppl 2:477-483.

Zarpelon AC, Fattori V, Souto FO, Pinto LG, Pinho-Ribeiro FA, Ruiz-Miyazawa KW, Turato WM, Cunha TM, Da Costa FB, Cunha FQ, Casagrande R, Arakawa NS, Verri WA Jr. Erratum to: The Sesquiterpene Lactone, Budlein A, Inhibits Antigen-Induced Arthritis in Mice: Role of NF-κB and Cytokines. Inflammation. 2017 Sep 6.

Zucoloto AZ, Manchope MF, Staurengo-Ferrari L, Alves-Filho JC, Cunha TM, Antunes MM, Menezes GB, Cunha FQ, Casagrande R, Verri WA Jr. Probucol attenuates overt pain-like behavior and carrageenan-induced inflammatory hyperalgesia and leukocyte recruitment by inhibiting NF-кB activation and cytokine production without antioxidant effects. Inflamm Res. 2017 Jul;66(7):591-602.

Zucoloto AZ, Manchope MF, Staurengo-Ferrari L, Pinho-Ribeiro FA, Zarpelon AC, Saraiva ALL, Cecílio NT, Alves-Filho JC, Cunha TM, Menezes GB, Cunha FQ, Casagrande R, Verri WA Jr. Probucol attenuates lipopolysaccharide-induced leukocyte recruitment and inflammatory hyperalgesia: effect on NF-кB activation and cytokine production. Eur J Pharmacol. 2017 Aug 15;809:52-63.


Alves-Filho JC, Pålsson-McDermott EM. Pyruvate Kinase M2: A Potential Target for Regulating Inflammation. Front Immunol. 2016 Apr 21;7:145.

Alves-Lopes R, Neves KB, Montezano AC, Harvey A, Carneiro FS, Touyz RM, Tostes RC. Internal Pudental Artery Dysfunction in Diabetes Mellitus Is Mediated by NOX1-Derived ROS-, Nrf2-, and Rho Kinase-Dependent Mechanisms. Hypertension. 2016 Oct;68(4):1056-64.

Alves-Lopes R, Neves KB, Silva MA, Olivon VC, Ruginsk SG, Antunes-Rodrigues J, Ramalho LN, Tostes RC, Carneiro FS. Functional and structural changes in internal pudendal arteries underlie erectile dysfunction induced by androgen deprivation. Asian J Androl. 2016 Jul 5.

Bassi GS, do C Malvar D, Cunha TM, Cunha FQ, Kanashiro A. Spinal GABA-B receptor modulates neutrophil recruitment to the knee joint in zymosan-induced arthritis. Naunyn Schmiedebergs Arch Pharmacol. 2016 Aug;389(8):851-61. Doi: 10.1007/s00210-016-1248-0. PubMed PMID: 27106212.

Bertolini TB, de Souza AI, Gembre AF, Piñeros AR, Prado Rde Q, Silva JS, Ramalho LN, Bonato VL. Genetic background affects the expansion of macrophage subsets in the lungs of Mycobacterium tuberculosis-infected hosts. Immunology. 2016 May;148(1):102-13.

Bradley WP, Boyer MA, Nguyen HT, Birdwell LD, Yu J, Ribeiro JM, Weiss SR, Zamboni DS, Roy CR, Shin S. Primary Role for Toll-Like Receptor-Driven Tumor Necrosis Factor Rather than Cytosolic Immune Detection in Restricting Coxiella burnetii Phase II Replication within Mouse Macrophages. Infect Immun. 2016 Mar 24;84(4):998-1015.

Brito MF, Ferreira JV, Souza LR, Gemaque LR, Sousa KP, Santos CF, Braga FS, Pernomian L, Silva CH, Santos CB. Taft CA, Hage-Melim LI. Computational Molecular Modeling of Compounds from Amaryllidaceae Family as Potential Acetylcholinesterase Inhibitors. Current Bioactive Compounds, 2016.

Bruder-Nascimento T, Callera G, Montezano AC, Antunes TT, He Y, Cat AN, Ferreira NS, Barreto PA, Olivon VC, Tostes RC, Touyz RM. Renoprotective Effects of Atorvastatin in Diabetic Mice: Downregulation of RhoA and Upregulation of Akt/GSK3. PLoS One. 2016 Sep 20;11(9):e0162731.

Bruder-Nascimento T, Ferreira NS, Zanotto CZ, Ramalho F, Pequeno IO, Olivon VC, Neves KB, Alves-Lopes R, Campos E, Silva CA, Fazan R, Carlos D, Mestriner FL, Prado D, Pereira FV, Braga T, Luiz JP, Cau SB, Elias PC, Moreira AC, Câmara NO, Zamboni DS, Alves-Filho JC, Tostes RC. NLRP3 Inflammasome Mediates Aldosterone-Induced Vascular Damage. Circulation. 2016 Dec 6;134(23):1866-1880.

Bueno-Silva B, Franchin M, Alves CF, Denny C, Colón DF, Cunha TM, Alencar SM, Napimoga MH, Rosalen PL. Main pathways of action of Brazilian red propolis on the modulation of neutrophils migration in the inflammatory process. Phytomedicine. 2016 Dec 1;23(13):1583-1590.

Caliari-Oliveira C, Yaochite JN, Ramalho LN, Palma PV, Carlos D, Cunha Fde Q, De Souza DA, Frade MA, Covas DT, Malmegrim KC, Oliveira MC, Voltarelli JC. Xenogeneic Mesenchymal Stromal Cells Improve Wound Healing and Modulate the Immune Response in an Extensive Burn Model. Cell Transplant. 2016;25(2):201-15.

Carregaro V, Napimoga MH, Peres RS, Benevides L, Sacramento LA, Pinto LG, Grespan R, Cunha TM, da Silva JS, Cunha FQ. Therapeutic Treatment of Arthritic Mice with 15-Deoxy Δ(12,14)-Prostaglandin J(2) (15d-PGJ(2)) Ameliorates Disease through the Suppression of Th17 Cells and the Induction of CD4(+)CD25(-)FOXP3(+) Cells. Mediators Inflamm. 2016.

Carvalho H, Laurindo I, Ranza R, Titton D, Bertolo M, Bianchi W, Brenol C, Castelar G, Castro G, Costa I, Duarte A, Fernandes V, Freire M, Louzada P, Macieira J, Miranda J, Moraes J, Pereira I, Sauma M, Stadler B, Toledo R, Valim V, Baaklini C. SAT0586-Herpes Zoster in The Brazilian Register. Annals of the Rheumatic Diseases. 2016;75:881.3-882.

Cavalcanti CA, Silva Jde A, Pita Wde B, Veit TD, Monticielo OA, Xavier RM, Brenol JC, Brenol CV, Fragoso TS, Barbosa AD, Duarte ÂL, Oliveira RD, Louzada-Júnior P, Donadi EA, Crovella S, Chies JA, Sandrin-Garcia P. Vitamin D receptor polymorphisms and expression profile in rheumatoid arthritis Brazilian patients. Mol Biol Rep. 2016 Jan;43(1):41-51.

Chaves de Souza JA, Frasnelli SC, Curylofo-Zotti FA, Ávila-Campos MJ, Spolidório LC, Zamboni DS, Graves DT, Rossa C Jr. NOD1 in the modulation of host-microbe interactions and inflammatory bone resorption in the periodontal disease model. Immunology. 2016 Dec;149(4):374-385.

Costa DL, Lima-Júnior DS, Nascimento MS, Sacramento LA, Almeida RP, Carregaro V, Silva JS. CCR2 signaling contributes to the differentiation of protective inflammatory dendritic cells in Leishmania braziliensis infection. J Leukoc Biol. 2016 Aug;100(2):423-32.

Costa FR, Françozo MC, de Oliveira GG, Ignacio A, Castoldi A, Zamboni DS, Ramos SG, Câmara NO, de Zoete MR, Palm NW, Flavell RA, Silva JS, Carlos D. Gut microbiota translocation to the pancreatic lymph nodes triggers NOD2 activation and contributes to T1D onset. J Exp Med. 2016 Jun 27;213(7):1223-39.

Costa FR, Mota CM, Santiago FM, Silva MV, Ferreira MD, Fonseca DM, Silva JS, Mineo JR, Mineo TW. GITR Activation Positively Regulates Immune Responses against Toxoplasma gondii. PLoS One. 2016 Mar 30;11(3):e0152622.

Costa RM, Filgueira FP, Tostes RC, Carvalho MH, Akamine EH, Lobato NS. H2O2 generated from mitochondrial electron transport chain in thoracic perivascular adipose tissue is crucial for modulation of vascular smooth muscle contraction. Vascul Pharmacol. 2016 Sep;84:28-37.

Cunha MG, Franchin M, Paula-Eduardo LF, Freires IA, Beutler JA, Alencar SM, Ikegaki M, CP Tabchoury, Cunha TM, Rosalen PL. Anti-inflammatory and anti-biofilm properties of ent-nemorosone from Brazilian geopropolis. Journal of Functional Foods. 2016 Oct;26:27-35. Doi: 10.1016/j.jff.2016.07.009.

Czaikoski PG, Mota JM, Nascimento DC, Sônego F, Castanheira FV, Melo PH, Scortegagna GT, Silva RL, Barroso-Sousa R, Souto FO, Pazin-Filho A, Figueiredo F, Alves-Filho JC, Cunha FQ. Neutrophil Extracellular Traps Induce Organ Damage during Experimental and Clinical Sepsis. PLoS One. 2016 Feb 5;11(2):e0148142.

da Costa RM, Fais RS, Dechandt CR, Louzada-Junior P, Alberici LC, Lobato NS, Tostes RC. Increased mitochondrial ROS generation mediates the loss of PVAT anticontractile effect in HFD-treated obese mice. Br J Pharmacol. 2016 Dec 8.

da Costa RM, Neves KB, Mestriner FL, Louzada-Junior P, Bruder-Nascimento T, Tostes RC. TNF-α induces vascular insulin resistance via positive modulation of PTEN and decreased Akt/eNOS/NO signaling in high fat diet-fed mice. Cardiovasc Diabetol. 2016 Aug 25;15(1):119.

da Silva CH, Taft CA. 3D descriptors calculation and conformational search to investigate potential bioactive conformations, with application in 3D-QSAR and virtual screening in drug design. J Biomol Struct Dyn. 2016 Oct 14:1-9.

da Silva Dias IC, Carabelli B, Ishii DK, de Morais H, de Carvalho MC, Rizzo de Souza LE, Zanata SM, Brandão ML, Cunha TM, Ferraz AC, Cunha JM, Zanoveli JM. Indoleamine-2,3-Dioxygenase/Kynurenine Pathway as a Potential Pharmacological Target to Treat Depression Associated with Diabetes. Mol Neurobiol. 2016 Dec;53(10):6997-7009.

David BA, Rezende RM, Antunes MM, Santos MM, Freitas Lopes MA, Diniz AB, Sousa Pereira RV, Marchesi SC, Alvarenga DM, Nakagaki BN, Araújo AM, Dos Reis DS, Rocha RM, Marques PE, Lee WY, Deniset J, Liew PX, Rubino S, Cox L, Pinho V, Cunha TM, Fernandes GR, Oliveira AG, Teixeira MM, Kubes P, Menezes GB. Combination of Mass Cytometry and Imaging Analysis Reveals Origin, Location, and Functional Repopulation of Liver Myeloid Cells in Mice. Gastroenterology. 2016 Dec;151(6):1176-1191.

Davoli-Ferreira M, Fonseca DM, Mota CM, Dias MS, Lima-Junior DS, da Silva MV, Quirino GF, Zamboni DS, Silva JS, Mineo TW. Nucleotide-binding oligomerization domain-containing protein 2 prompts potent inflammatory stimuli during Neospora caninum infection. Sci Rep. 2016 Jul 5;6:29289.

de Molon RS, Hsu C, Bezouglaia O, Dry SM, Pirih FQ, Soundia A, Cunha FQ, Cirelli JA, Aghaloo TL, Tetradis S. Rheumatoid Arthritis Exacerbates the Severity of Osteonecrosis of the Jaws (ONJ) in Mice. A Randomized, Prospective, Controlled Animal Study. J Bone Miner Res. 2016 Aug;31(8):1596-607.

de Oliveira LF, Romano MM, de Carvalho EE, Cabeza JM, Salgado HC, Fazan Júnior R, Costa RS, da Silva JS, Higuchi Mde L, Maciel BC, Cunha-Neto E, Marin-Neto JA, Simões MV. Histopathological Correlates of Global and Segmental Left Ventricular Systolic Dysfunction in Experimental Chronic Chagas Cardiomyopathy. J Am Heart Assoc. 2016 Jan 21;5(1).

de Oliveira LM, de Oliveira TS, da Costa RM, de Souza Gil E, Costa EA, Passaglia Rde C, Filgueira FP, Ghedini PC. The vasorelaxant effect of gallic acid involves endothelium-dependent and -independent mechanisms. Vascul Pharmacol. 2016 Jun;81:69-74.

de Paula Costa G, Lopes LR, da Silva MC, Horta AL, Pontes WM, Milanezi CM, Guedes PM, de Lima WG, Schulz R, da Silva JS, Talvani A. Doxycycline and Benznidazole Reduce the Profile of Th1, Th2, and Th17 Chemokines and Chemokine Receptors in Cardiac Tissue from Chronic Trypanosoma cruzi-Infected Dogs. Mediators Inflamm. 2016.

Dias-Teixeira KL, Pereira RM, Silva JS, Fasel N, Aktas BH, Lopes UG. Unveiling the Role of the Integrated Endoplasmic Reticulum Stress Response in Leishmania Infection – Future Perspectives. Front Immunol. 2016 Jul 22;7:283.

Diniz EM, Poiani JG, Taft CA, Silva CH. Structure-based drug design, molecular dynamics and ADME/Tox to investigate protein kinase anti-cancer agents. Current Bioactive Compounds, 2016.

Diniz EM, Tomich de Paula da Silva CH, Gómez-Perez V, Federico LB, Campos Rosa JM. GRIND2-based 3D-QSAR and prediction of activity spectra for symmetrical bis-pyridinium salts with promastigote antileishmanial activity. J Biomol Struct Dyn. 2016 Sep 6:1-11.

Dos Santos Picanço LC, Ozela PF, de Fátima de Brito Brito M, Pinheiro AA, Padilha EC, Braga FS, de Paula da Silva CH, Dos Santos CB, Rosa JM, da Silva Hage-Melim LI. Alzheimer’s disease: A review from the pathophysiology to diagnosis, new perspectives for pharmacological treatment. Curr Med Chem. 2016 Dec 12.

Ellebedy AH, Jackson KJ, Kissick HT, Nakaya HI, Davis CW, Roskin KM, McElroy AK, Oshansky CM, Elbein R, Thomas S, Lyon GM, Spiropoulou CF, Mehta AK, Thomas PG, Boyd SD, Ahmed R. Defining antigen-specific plasmablast and memory B cell subsets in human blood after viral infection or vaccination. Nat Immunol. 2016 Oct;17(10):1226-34.

Falcão J, Valim V, Titton D, Ranza R, Carvalho H, Bianchi W, Stadler B, Fernandes V, Louzada P, Bertolo M, Duarte A, Macieira J, Miranda J, Castelar G, Freire M, Toledo R, Moraes J, Costa I, Pereira I, Sauma M, Castro G, Brenol C, Zandonade E, Laurindo I, Baaklini C. FRI0195-Switching from anti-TNF To Non anti-TNF Therapy Yield Better Survival in Rheumatoid Arthritis (RA): Results from Brazilian Register of Biological Agents in Rheumatic Diseases. Annals of the Rheumatic Diseases. 2016; 75:501.1-501.

Fattori V, Pinho-Ribeiro FA, Borghi SM, Alves-Filho JC, Cunha TM, Cunha FQ, Casagrande R, Verri WA Jr. Curcumin inhibits superoxide anion-induced pain-like behavior and leukocyte recruitment by increasing Nrf2 expression and reducing NF-κB activation. Inflamm Res. 2015 Dec;64(12):993-1003.

Federico LB, Almeida JR, Taft CA, Silva CH. Ligand and Structure-Based Drug Design as Strategies for the Screening of New BACE1 Inhibitor Candidates. Current Physical Chemistry, 2016.

Federico LB, Santos CB, Lobato CC, Gomes JS, Rosa JC, Silva CH. 3D descriptors calculation and conformational search to investigate potential bioactive conformations, with application in 3D-QSAR. Journal of Computational and Theoretical Nanoscience, 2016.

Fernandes TD, Cunha LD, Ribeiro JM, Massis LM, Lima-Junior DS, Newton HJ, Zamboni DS. Murine Alveolar Macrophages Are Highly Susceptible to Replication of Coxiella burnetii Phase II In Vitro. Infect Immun. 2016 Aug 19;84(9):2439-48.

Figueredo AS, Oliveira MG, Safadi GM, Silva CH, Silva VB, Aquino GL. The Natural Alkaloid Piperine and its Acid and Ester Synthetic Derivatives are Acetylcholinesterase Inhibitors. Current Physical Chemistry, 2016.

Franca RF, Costa RS, Silva JR, Peres RS, Mendonça LR, Colón DF, Alves-Filho JC, Cunha FQ. IL-33 signaling is essential to attenuate viral-induced encephalitis development by downregulating iNOS expression in the central nervous system. J Neuroinflammation. 2016 Jun 22;13(1):159.

Franchin M, Cólon DF, Castanheira FV, da Cunha MG, Bueno-Silva B, Alencar SM, Cunha TM, Rosalen PL. Vestitol Isolated from Brazilian Red Propolis Inhibits Neutrophils Migration in the Inflammatory Process: Elucidation of the Mechanism of Action. J Nat Prod. 2016 Apr 22;79(4):954-60.

Franchin M, Colón DF, da Cunha MG, Castanheira FV, Saraiva AL, Bueno-Silva B, Alencar SM, Cunha TM, Rosalen PL. Neovestitol, an isoflavonoid isolated from Brazilian red propolis, reduces acute and chronic inflammation: involvement of nitric oxide and IL-6. Sci Rep. 2016 Nov 7;6:36401.

Franchin M, Rosalen PL, da Cunha MG, Silva RL, Colón DF, Bassi GS, de Alencar SM, Ikegaki M, Alves-Filho JC, Cunha FQ, Beutler JA, Cunha TM. Cinnamoyloxy-mammeisin Isolated from Geopropolis Attenuates Inflammatory Process by Inhibiting Cytokine Production: Involvement of MAPK, AP-1, and NF-κB. J Nat Prod. 2016 Jul 22;79(7):1828-33.

Galvão I, Dias AC, Tavares LD, Rodrigues IP, Queiroz-Junior CM, Costa VV, Reis AC, Ribeiro Oliveira RD, Louzada-Junior P, Souza DG, Leng L, Bucala R, Sousa LP, Bozza MT, Teixeira MM, Amaral FA. Macrophage migration inhibitory factor drives neutrophil accumulation by facilitating IL-1β production in a murine model of acute gout. J Leukoc Biol. 2016 Jun;99(6):1035-43.

Gohar EY, Giachini FR, Pollock DM, Tostes RC. Role of the endothelin system in sexual dimorphism in cardiovascular and renal diseases. Life Sci. 2016 Aug 15;159:20-9.

Gonzaga NA, Simplicio JA, Leite LN, Vale GT, Carballido JM, Alves-Filho JC, Tirapelli CR. Data on the mechanisms underlying succinate-induced aortic contraction. Data Brief. 2016 Aug 31;9:206-12.

Guerrero AT, Pinto LG, Cunha FQ, Ferreira SH, Alves-Filho JC, Verri WA Jr, Cunha TM. Mechanisms underlying the hyperalgesic responses triggered by joint activation of TLR4. Pharmacol Rep. 2016 Dec;68(6):1293-1300.

Huang L, Ou R, Rabelo de Souza G, Cunha TM, Lemos H, Mohamed E, Li L, Pacholczyk G, Randall J, Munn DH, Mellor AL. Virus Infections Incite Pain Hypersensitivity by Inducing Indoleamine 2,3 Dioxygenase. PLoS Pathog. 2016 May 11;12(5):e1005615.

Im SJ, Hashimoto M, Gerner MY, Lee J, Kissick HT, Burger MC, Shan Q, Hale JS,  Lee J, Nasti TH, Sharpe AH, Freeman GJ, Germain RN, Nakaya HI, Xue HH, Ahmed R. Defining CD8(+) T cells that provide the proliferative burst after PD-1 therapy. Nature. 2016 Sep 15;537(7620):417-421.

Kanashiro A, Talbot J, Peres RS, Pinto LG, Bassi GS, Cunha TM, Cunha FQ. Neutrophil Recruitment and Articular Hyperalgesia in Antigen-Induced Arthritis are Modulated by the Cholinergic Anti-Inflammatory Pathway. Basic Clin Pharmacol Toxicol. 2016 Nov;119(5):453-457.

Kawano DF, Silva CH, Taft CA. Design of a New Synthetically Accessible Antibacterial Sulfona-mide Through Quantitative Structure-Activity Relationship (QSAR) Studies. Current Physical Chemistry, 2016.

Kawano DF, Taft CA, Silva CH. Prospecting for new inhibitors of anaplastic lymphoma kinase, a clinically relevant oncogenic drug target. Current Bioactive Compounds, 2016.

Leite LN, Gonzaga NA, Simplicio JA, do Vale GT, Carballido JM, Alves-Filho JC, Tirapelli CR. Pharmacological characterization of the mechanisms underlying the vascular effects of succinate. Eur J Pharmacol. 2016 Oct 15;789:334-43.

Lima VV, Giachini FR, Matsumoto T, Li W, Bressan AF, Chawla D, Webb RC, Ergul A, Tostes RC. High-fat diet increases O-GlcNAc levels in cerebral arteries: a link to vascular dysfunction associated with hyperlipidaemia/obesity? Clin Sci (Lond). 2016 Jun 1;130(11):871-80.

Lima VV, Zemse SM, Chiao CW, Bomfim GF, Tostes RC, Clinton Webb R, Giachini FR. Interleukin-10 limits increased blood pressure and vascular RhoA/Rho-kinase signaling in angiotensin II-infused mice. Life Sci. 2016 Jan 15;145:137-43.

Longhi-Balbinot DT, Rossaneis AC, Pinho-Ribeiro FA, Bertozzi MM, Cunha FQ, Alves-Filho JC, Cunha TM, Peron JP, Miranda KM, Casagrande R, Verri WA Jr. The nitroxyl donor, Angeli’s salt, reduces chronic constriction injury-induced neuropathic pain. Chem Biol Interact. 2016 Aug 25;256:1-8.

Lopes AH, Brandolini L, Aramini A, Bianchini G, Silva RL, Zaperlon AC, Verri WA Jr, Alves-Filho JC, Cunha FQ, Teixeira MM, Allegretti M, Cunha TM. DF2755A, a novel non-competitive allosteric inhibitor of CXCR1/2, reduces inflammatory and post-operative pain. Pharmacol Res. 2016 Jan;103:69-79.

Moreira JD, Pernomian L, Gomes MS, Moreira RP, do Prado AF, da Silva CH, de Oliveira AM. Enhanced nitric oxide generation from nitric oxide synthases as the cause of increased peroxynitrite formation during acute restraint stress: Effects on carotid responsiveness to angiotensinergic stimuli in type-1 diabetic rats. Eur J Pharmacol. 2016 Jul 15;783:11-22.

Mota CM, Oliveira AC, Davoli-Ferreira M, Silva MV, Santiago FM, Nadipuram SM, Vashisht AA, Wohlschlegel JA, Bradley PJ, Silva JS, Mineo JR, Mineo TW. Neospora caninum Activates p38 MAPK as an Evasion Mechanism against Innate Immunity. Front Microbiol. 2016 Sep 13;7:1456.

Mota JM, Leite CA, Souza LE, Melo PH, Nascimento DC, de-Deus-Wagatsuma VM, Temporal J, Figueiredo F, Noushmehr H, Alves-Filho JC, Cunha FQ, Rego EM. Post-Sepsis State Induces Tumor-Associated Macrophage Accumulation through CXCR4/CXCL12 and Favors Tumor Progression in Mice. Cancer Immunol Res. 2016 Apr;4(4):312-22.

Muñoz M, Craske M, Severino P, de Lima TM, Labhart P, Chammas R, Velasco IT, Machado MC, Egan B, Nakaya HI, Pinheiro da Silva F. Antimicrobial peptide LL-37 participates in the transcriptional regulation of melanoma cells. J Cancer. 2016  Nov 26;7(15):2341-2345.

Nakaya HI, Clutterbuck E, Kazmin D, Wang L, Cortese M, Bosinger SE, Patel NB, Zak DE, Aderem A, Dong T, Del Giudice G, Rappuoli R, Cerundolo V, Pollard AJ, Pulendran B, Siegrist CA. Systems biology of immunity to MF59-adjuvanted versus nonadjuvanted trivalent seasonal influenza vaccines in early childhood. Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):1853-8.

Nakiri GS, Monsignore LM, de Siqueira FM, Louzada P Jr, Castro-Afonso LH, Abud DG. Transhepatic Embolization of Bilateral Pulmonary Artery Aneurysm with N-Butyl Cyanoacrylate and Coils in Behçet Disease. J Vasc Interv Radiol. 2016 Feb;27(2):293-5.

Nascimento MS, Ferreira MD, Quirino GF, Maruyama SR, Krishnaswamy JK, Liu D, Berlink J, Fonseca DM, Zamboni DS, Carregaro V, Almeida RP, Cunha TM, Eisenbarth SS, Silva JS. NOD2-RIP2-Mediated Signaling Helps Shape Adaptive Immunity in Visceral Leishmaniasis. J Infect Dis. 2016 Dec 1;214(11):1647-1657.

Nonato AO, Olivon VC, Dela Justina V, Zanotto CZ, Webb RC, Tostes RC, Lima VV, Giachini FR. Impaired Ca(2+) Homeostasis and Decreased Orai1 Expression Modulates Arterial Hyporeactivity to Vasoconstrictors During Endotoxemia. Inflammation. 2016 Jun;39(3):1188-97.

Okada SS, de Oliveira EM, de Araújo TH, Rodrigues MR, Albuquerque RC, Mortara RA, Taniwaki NN, Nakaya HI, Campa A, Moreno AC. Myeloperoxidase in human peripheral blood lymphocytes: Production and subcellular localization. Cell Immunol. 2016 Feb;300:18-25.

Penha Filho RA, Diaz SJ, Medina Tda S, Chang YF, da Silva JS, Berchieri A Jr. Evaluation of protective immune response against fowl typhoid in chickens vaccinated with the attenuated strain Salmonella Gallinarum ΔcobSΔcbiA. Res Vet Sci. 2016 Aug;107:220-7.

Peres RS, Menezes GB, Teixeira MM, Cunha FQ. Pharmacological opportunities to control inflammatory diseases through inhibition of the leukocyte recruitment. Pharmacol Res. 2016 Oct;112:37-48.

Pinho-Ribeiro FA, Fattori V, Zarpelon AC, Borghi SM, Staurengo-Ferrari L, Carvalho TT, Alves-Filho JC, Cunha FQ, Cunha TM, Casagrande R, Verri WA Jr. Pyrrolidine dithiocarbamate inhibits superoxide anion-induced pain and inflammation in the paw skin and spinal cord by targeting NF-κB and oxidative stress. Inflammopharmacology. 2016 Jun;24(2-3):97-107.

Pinho-Ribeiro FA, Zarpelon AC, Mizokami SS, Borghi SM, Bordignon J, Silva RL, Cunha TM, Alves-Filho JC, Cunha FQ, Casagrande R, Verri WA Jr. The citrus flavonone naringenin reduces lipopolysaccharide-induced inflammatory pain and leukocyte recruitment by inhibiting NF-κB activation. J Nutr Biochem. 2016 Jul;33:8-14.

Pinke KH, Lima HG, Cunha FQ, Lara VS. Mast cells phagocyte Candida albicans and produce nitric oxide by mechanisms involving TLR2 and Dectin-1. Immunobiology. 2016 Feb;221(2):220-7.

Pucca MB, Cerni FA, Cordeiro FA, Peigneur S, Cunha TM, Tytgat J, Arantes EC. Ts8 scorpion toxin inhibits the Kv4.2 channel and produces nociception in vivo. Toxicon. 2016 Sep 1;119:244-52.

Quadros AU, Cunha TM. C5a and pain development: An old molecule, a new target. Pharmacol Res. 2016 Oct;112:58-67.

Quadros AU, Pinto LG, Fonseca MM, Kusuda R, Cunha FQ, Cunha TM. Dynamic weight bearing is an efficient and predictable method for evaluation of arthritic nociception and its pathophysiological mechanisms in mice. Sci Rep. 2015 Oct 29;5:14648.

Quirino GF, Nascimento MS, Davoli-Ferreira M, Sacramento LA, Lima MH, Almeida RP, Carregaro V, Silva JS. Interleukin-27 (IL-27) Mediates Susceptibility to Visceral Leishmaniasis by Suppressing the IL-17-Neutrophil Response. Infect Immun. 2016 Jul 21;84(8):2289-98.

Ranza R, Laurindo I, Titton D, Bertolo M, Bianchi W, Brenol C, Bustamante M, Carvalho H, Castro G, Costa I, Duarte A, Fernandes V, Freire M, Louzada P, Maciera J, Miranda J, Moraes J, Pereira I, Pinheiro G, Sauma M, Stadler B, Toledo R, Valim V, Baaklini C, Descalzo M . THU0631-Incidence of Serious Adverse Events in Patients with Rheumatoid Arthritis Exposed To Biologic Therapies. Annals of the Rheumatic Diseases. 2016;75:422.1-422.

Ravindran R, Loebbermann J, Nakaya HI, Khan N, Ma H, Gama L, Machiah DK, Lawson B, Hakimpour P, Wang YC, Li S, Sharma P, Kaufman RJ, Martinez J, Pulendran B. The amino acid sensor GCN2 controls gut inflammation by inhibiting inflammasome activation. Nature. 2016 Mar 24;531(7595):523-7.

Ribeiro RA, Wanderley CW, Wong DV, Mota JM, Leite CA, Souza MH, Cunha FQ, Lima-Júnior RC. Irinotecan- and 5-fluorouracil-induced intestinal mucositis: insights into pathogenesis and therapeutic perspectives. Cancer Chemother Pharmacol. 2016 Nov;78(5):881-893.

Rodrigues FL, Lopes RA, Fais RS, de Oliveira L, Prado CM, Tostes RC, Carneiro FS. Erectile dysfunction in heart failure rats is associated with increased neurogenic contractions in cavernous tissue and internal pudendal artery. Life Sci. 2016 Jan 15;145:9-18.

Santa-Cecília FV, Socias B, Ouidja MO, Sepulveda-Diaz JE, Acuña L, Silva RL, Michel PP, Del-Bel E, Cunha TM, Raisman-Vozari R. Doxycycline Suppresses Microglial Activation by Inhibiting the p38 MAPK and NF-kB Signaling Pathways. Neurotox Res. 2016 May;29(4):447-59.

Sant’Anna MB, Kusuda R, Bozzo TA, Bassi GS, Alves-Filho JC, Cunha FQ, Ferreira SH, Souza GR, Cunha TM. Medial plantar nerve ligation as a novel model of neuropathic pain in mice: pharmacological and molecular characterization. Sci Rep. 2016 May 27;6:26955.

Santos CB, Silva CH, Serafim RB, Rodriguez D, Padilha E, Freitas C. New PPARα/γ/δ Optimal Activator Rationally Designed by Computational Methods. Journal of the Brazilian Chemical Society (Impresso), 2016.

Santos CF, Silva ES, Martins AM, Silva CH, Santos CB, Hage-Melim LI. Molecular Modeling of Peptide Derivatives NS3 Protease Inhibitors of the Type 2 Dengue Virus. Current Physical Chemistry, 2016.

Santos SS, Carmo AM, Brunialti MK, Machado FR, Azevedo LC, Assunção M, Trevelin SC, Cunha FQ, Salomao R. Modulation of monocytes in septic patients: preserved phagocytic activity, increased ROS and NO generation, and decreased production of inflammatory cytokines. Intensive Care Med Exp. 2016 Dec;4(1):5.

Schons-Fonseca L, da Silva JB, Milanez JS, Domingos RH, Smith JL, Nakaya HI, Grossman AD, Ho PL, da Costa RM. Analysis of LexA binding sites and transcriptomics in response to genotoxic stress in Leptospira interrogans. Nucleic Acids Res. 2016 Feb 18;44(3):1179-91.

Schroder WA, Anraku I, Le TT, Hirata TD, Nakaya HI, Major L, Ellis JJ, Suhrbier A. SerpinB2 Deficiency Results in a Stratum Corneum Defect and Increased Sensitivity to Topically Applied Inflammatory Agents. Am J Pathol. 2016 Jun;186(6):1511-23.

Silva DF, Alves CQ, Brandão HN, David JM, David JP, Silva RL, Franchin M, Cunha TM, Martins FT, Oliveira CM. Poligalen, a new coumarin from Polygala boliviensis, reduces the release of TNF and IL-6 independent of NF-kB downregulation. Fitoterapia. 2016 Sep;113:139-43.

Silva IX, Oliveira MG, Conceição EC, Taft CA, Silva CH, Silva VB. Binding model of capsaicin is able to reach the peripheral anionic site of acetylcholinesterase. Current Bioactive Compounds, 2016.

Silva RL, Castanheira FV, Figueiredo JG, Bassi GS, Ferreira SH, Cunha FQ, Cunha TM, Kanashiro A. Pharmacological Beta-Adrenergic Receptor Activation Attenuates Neutrophil Recruitment by a Mechanism Dependent on Nicotinic Receptor and the Spleen. Inflammation. 2016 Aug;39(4):1405-13.

Simplicio JA, Hipólito UV, Vale GT, Callera GE, Pereira CA, Touyz RM, Tostes RC, Tirapelli CR. Acute Ethanol Intake Induces NAD(P)H Oxidase Activation and Rhoa Translocation in Resistance Arteries. Arq Bras Cardiol. 2016 Nov;107(5):427-436.

Sônego F, Castanheira FV, Ferreira RG, Kanashiro A, Leite CA, Nascimento DC, Colón DF, Borges Vde F, Alves-Filho JC, Cunha FQ. Paradoxical Roles of the Neutrophil in Sepsis: Protective and Deleterious. Front Immunol. 2016 Apr 26;7:155.

Souza JA, Medeiros MC, Rocha FR, de Aquino SG, Ávila-Campos MJ, Spolidorio LC, Zamboni DS, Graves DT, Rossa C Junior. Role of NOD2 and RIP2 in host-microbe interactions with Gram-negative bacteria: insights from the periodontal disease model. Innate Immun. 2016 Nov;22(8):598-611.

Souza LR, Picanco RM, Pinheiro AA, Silva KR, Silva CH, Santos CB, Hage-Melim, LI. Development of Monoamine Oxidase B Inhibitors with Antiparkinson Activity. Current Physical Chemistry, 2016.

Toffoli Ribeiro C, Louzada Júnior P, de Sá MF. Correlation between Systemic Lupus Erythematosus Activity and Plasma Levels of Monomeric Prolactin and Macroprolactin. Endocr Metab Immune Disord Drug Targets. 2016;16(1):21-7. PubMed PMID: 27237539.

Tostes RC, Carneiro FS, Carvalho MH, Reckelhoff JF. Reactive oxygen species: players in the cardiovascular effects of testosterone. Am J Physiol Regul Integr Comp Physiol. 2016 Jan 1;310(1):R1-14.

Trevelin SC, Dos Santos CX, Ferreira RG, de Sá Lima L, Silva RL, Scavone C, Curi R, Alves-Filho JC, Cunha TM, Roxo-Júnior P, Cervi MC, Laurindo FR, Hothersall JS, Cobb AM, Zhang M, Ivetic A, Shah AM, Lopes LR, Cunha FQ. Apocynin and Nox2 regulate NF-κB by modifying thioredoxin-1 redox-state. Sci Rep. 2016 Oct 4;6:34581.

Turato WM, Sales-Campos H, Braga CB, Cunha SF, Silvah JH, da Silva JS, Marchini JS, de Barros Cardoso CR. The impact of intestinal resection on the immune function of short bowel syndrome patients. Hum Immunol. 2016 Dec;77(12):1202-1208.

Veras FP, Peres RS, Saraiva AL, Pinto LG, Louzada-Junior P, Cunha TM, Paschoal JA, Cunha FQ, Alves-Filho JC. Fructose 1,6-bisphosphate, a high-energy intermediate of glycolysis, attenuates experimental arthritis by activating anti-inflammatory adenosinergic pathway. Sci Rep. 2015 Oct 19;5:15171.

Vilela FM, Oliveira FM, Vicentini FT, Casagrande R, Verri WA Jr, Cunha TM, Fonseca MJ. Commercial sunscreen formulations: UVB irradiation stability and effect on UVB irradiation-induced skin oxidative stress and inflammation. J Photochem Photobiol B. 2016 Oct;163:413-20.

Zarpelon AC, Rodrigues FC, Lopes AH, Souza GR, Carvalho TT, Pinto LG, Xu D, Ferreira SH, Alves-Filho JC, McInnes IB, Ryffel B, Quesniaux VF, Reverchon F, Mortaud S, Menuet A, Liew FY, Cunha FQ, Cunha TM, Verri WA Jr. Spinal cord oligodendrocyte-derived alarmin IL-33 mediates neuropathic pain. FASEB J. 2016 Jan;30(1):54-65.

Zoccal KF, Sorgi CA, Hori JI, Paula-Silva FW, Arantes EC, Serezani CH, Zamboni DS, Faccioli LH. Opposing roles of LTB4 and PGE2 in regulating the inflammasome-dependent scorpion venom-induced mortality. Nat Commun. 2016 Feb 23;7:10760.


Akondy RS, Johnson PL, Nakaya HI, Edupuganti S, Mulligan MJ, Lawson B, Miller JD, Pulendran B, Antia R, Ahmed R. Initial viral load determines the magnitude of the human CD8 T cell response to yellow fever vaccination. Proc Natl Acad Sci U S A. 2015 Mar 10;112(10):3050-5.

Almeida GT, Lage RC, Anderson L, Venancio TM, Nakaya HI, Miyasato PA, Rofatto HK, Zerlotini A, Nakano E, Oliveira G, Verjovski-Almeida S. Synergy of Omeprazole and Praziquantel In Vitro Treatment against Schistosoma mansoni Adult Worms. PLoS Negl Trop Dis. 2015 Sep 24;9(9):e0004086.

Alves Filho Fd, Cavalcanti PM, Passaglia Rde C, Ballejo G. Long-lasting endothelium-dependent relaxation of isolated arteries caused by an extract from the bark of Combretum leprosum. Einstein (Sao Paulo). 2015 Jul-Sep;13(3):395-403.

Angelo HD, Gomes Silva II, Oliveira RD, Louzada-Júnior P, Donadi EA, Crovella S, Maia MM, de Souza PR, Sandrin-Garcia P. Interleukin-18, interleukin-12B and interferon-γ gene polymorphisms in Brazilian patients with rheumatoid arthritis: a pilot study. Tissue Antigens. 2015 Oct;86(4):276-8.

Bassi GS, Brognara F, Castania JA, Talbot J, Cunha TM, Cunha FQ, Ulloa L, Kanashiro A, Dias DP, Salgado HC. Baroreflex activation in conscious rats modulates the joint inflammatory response via sympathetic function. Brain Behav Immun. 2015 Oct;49:140-7.

Benevides L, da Fonseca DM, Donate PB, Tiezzi DG, De Carvalho DD, de Andrade JM, Martins GA, Silva JS. IL17 Promotes Mammary Tumor Progression by Changing the Behavior of Tumor Cells and Eliciting Tumorigenic Neutrophils Recruitment. Cancer Res. 2015 Sep 15;75(18):3788-99.

Bomfim GF, Echem C, Martins CB, Costa TJ, Sartoretto SM, Dos Santos RA, Oliveira MA, Akamine EH, Fortes ZB, Tostes RC, Webb RC, Carvalho MH. Toll-like receptor 4 inhibition reduces vascular inflammation in spontaneously hypertensive rats. Life Sci. 2015 Feb 1;122:1-7.

Borghi SM, Pinho-Ribeiro FA, Zarpelon AC, Cunha TM, Alves-Filho JC, Ferreira SH, Cunha FQ, Casagrande R, Verri WA Jr. Interleukin-10 limits intense acute swimming-induced muscle mechanical hyperalgesia in mice. Exp Physiol. 2015 Apr 20;100(5):531-44.

Bruder-Nascimento T, Callera GE, Montezano AC, He Y, Antunes TT, Nguyen Dinh Cat A, Tostes RC, Touyz RM. Vascular injury in diabetic db/db mice is ameliorated by atorvastatin: role of Rac1/2-sensitive Nox-dependent pathways. Clin Sci (Lond). 2015 Apr;128(7):411-23.

Campo VL, Ivanova IM, Carvalho I, Lopes CD, Carneiro ZA, Saalbach G, Schenkman S, da Silva JS, Nepogodiev SA, Field RA. Click chemistry oligomerisation of azido-alkyne-functionalised galactose accesses triazole-linked linear oligomers and macrocycles that inhibit Trypanosoma cruzi macrophage invasion. Tetrahedron. 2015 Sep 30;71(39):7344-7353.

Cardoso CP, de Oliveira AJ, Botoni FA, Rezende IC, Alves-Filho JC, Cunha Fde Q, Estanislau Jde A, Magno LA, Rios-Santos F. Interleukin-10 rs2227307 and CXCR2 rs1126579 polymorphisms modulate the predisposition to septic shock. Mem Inst Oswaldo Cruz. 2015 Jun;110(4):453-60.

Carlos D, Yaochite JN, Rocha FA, Toso VD, Malmegrim KC, Ramos SG, Jamur MC, Oliver C, Camara NO, Andrade MV, Cunha FQ, Silva JS. Mast cells control insulitis and increase Treg cells to confer protection against STZ-induced type 1 diabetes in mice. Eur J Immunol. 2015 Oct;45(10):2873-85.

Carregaro V, Ribeiro JM, Valenzuela JG, Souza-Júnior DL, Costa DL, Oliveira CJ, Sacramento LA, Nascimento MS, Milanezi CM, Cunha FQ, Silva JS. Nucleosides present on phlebotomine saliva induce immunossuppression and promote the infection establishment. PLoS Negl Trop Dis. 2015 Apr 7;9(4):e0003600.

Carvalho NB, Oliveira FS, Marinho FA, de Almeida LA, Fahel JS, Báfica A, Rothfuchs AG, Zamboni DS, Caliari MV, Oliveira SC. Nucleotide-binding oligomerization domain-2 (NOD2) regulates type-1 cytokine responses to Mycobacterium avium but is not required for host control of infection. Microbes Infect. 2015 May;17(5):337-44.

Carvalho TT, Borghi SM, Pinho-Ribeiro FA, Mizokami SS, Cunha TM, Ferreira SH, Cunha FQ, Casagrande R, Verri WA Jr. Granulocyte-colony stimulating factor (G-CSF)-induced mechanical hyperalgesia in mice: Role for peripheral TNFα, IL-1β and IL-10. Eur J Pharmacol. 2015 Feb 15;749:62-72.

Cerqueira DM, Pereira MS, Silva AL, Cunha LD, Zamboni DS. Caspase-1 but Not Caspase-11 Is Required for NLRC4-Mediated Pyroptosis and Restriction of Infection by Flagellated Legionella Species in Mouse Macrophages and In Vivo. J Immunol. 2015 Sep 1;195(5):2303-11.

Chignalia AZ, Oliveira MA, Debbas V, Dull RO, Laurindo FR, Touyz RM, Carvalho MH, Fortes ZB, Tostes RC. Testosterone induces leucocyte migration by NADPH oxidase-driven ROS- and COX2-dependent mechanisms. Clin Sci (Lond). 2015 Jul;129(1):39-48.

Conte FP, Ferraris FK, Costa TE, Pacheco P, Seito LN, Verri WA Jr, Cunha FQ, Penido C, Henriques MG. Effect of gedunin on acute articular inflammation and hypernociception in mice. Molecules. 2015 Feb 3;20(2):2636-57.

Costa TJ, Ceravolo GS, dos Santos RA, de Oliveira MA, Araújo PX, Giaquinto LR, Tostes RC, Akamine EH, Fortes ZB, Dantas AP, Carvalho MH. Association of testosterone with estrogen abolishes the beneficial effects of estrogen treatment by increasing ROS generation in aorta endothelial cells. Am J Physiol Heart Circ Physiol. 2015 Apr 1;308(7):H723-32.

Cunha EL, Santos CF, Braga FS, Costa JS, Silva RC, Favacho HA, Hage-Melim LI, Carvalho JC, Silva CH, Santos CB. Computational Investigation of Antifungal Compounds Using Molecular Modeling and Prediction of ADME/Tox Properties. Journal of Computational and Theoretical Nanoscience, v. 12, p. 3682-3691, 2015.

Cunha LD, Ribeiro JM, Fernandes TD, Massis LM, Khoo CA, Moffatt JH, Newton HJ, Roy CR, Zamboni DS. Inhibition of inflammasome activation by Coxiella burnetii type IV secretion system effector IcaA. Nat Commun. 2015 Dec 21;6:10205.

da Costa TA, Silva MJ, Alves PM, Chica JE, Barcelos EZ, Giani MA, Garlet GP, da Silva JS, Rodrigues Júnior V, Rodrigues DB, Cardoso CR. Inflammation Biomarkers of Advanced Disease in Nongingival Tissues of Chronic Periodontitis Patients. Mediators Inflamm. 2015;2015:983782.

Da Mota LM, Cruz BA, Albuquerque CP, Gonçalves DL, Ieda MM, Pereira IA, Carvalho JF, Pinheiro GR, Bertolo MB, Silva NA, Louzada Júnior P, Xavier RM, Giorgi RD, Lima RA. Orientações preliminares da Sociedade Brasileira de Reumatologia para avaliação e tratamento da tuberculose infecção latente em pacientes com artrite reumatoide na indisponibilidade do teste tuberculínico. Revista Brasileira de Reumatologia (Impresso). 2015;55:390-393.

Da Mota LM, Cruz BA, Albuquerque CP, Gonçalves DL, Ieda MM, Pereira IA, Carvalho JF, Pinheiro GR, Bertolo MB, Pinto MR, Louzada Júnior P, Xavier RM, Giorgi RD, Lima RA. Posicionamento sobre o uso de tofacitinibe no algoritmo do Consenso 2012 da Sociedade Brasileira de Reumatologia para o tratamento da artrite reumatoide. Revista Brasileira de Reumatologia (Impresso). 2015;55:1-5.

da Mota LM, Cruz BA, de Albuquerque CP, Gonçalves D, Laurindo IM, Pereira IA, de Carvalho JF, Pinheiro Gda R, Bertolo MB, da Silva NA, Louzada Júnior P, Xavier RM, Giorgi RD, Lima RA. [Preliminary guidelines of the Brazilian Society of Rheumatology for evaluation and treatment of tuberculosis latent infection in patients with rheumatoid arthritis, in face of unavailability of the tuberculin skin test]. Rev Bras Reumatol. 2015 Jul-Aug;55(4):390-3.

da Mota LM, Cruz BA, de Albuquerque CP, Gonçalves DP, Laurindo IM, Pereira IA, de Carvalho JF, Pinheiro Gda R, Bertolo MB, Pinto MR, Louzada-Junior P, Xavier RM, Giorgi RD, Lima RA. Update on the 2012 Brazilian Society of Rheumatology Guidelines for the treatment of rheumatoid arthritis: position on the use of tofacitinib. Rev Bras Reumatol. 2015 Nov-Dec;55(6):512-21.

de Andrade P, Galo OA, Carvalho MR, Lopes CD, Carneiro ZA, Sesti-Costa R, de Melo EB, Silva JS, Carvalho I. 1,2,3-Triazole-based analogue of benznidazole displays remarkable activity against Trypanosoma cruzi. Bioorg Med Chem. 2015 Nov 1;23(21):6815-26.

de Melo FM, Braga CJ, Pereira FV, Maricato JT, Origassa CS, Souza MF, Melo AC, Silva P, Tomaz SL, Gimenes KP, Scutti JA, Juliano MA, Zamboni DS, Câmara NO, Travassos LR, Ferreira LC, Rodrigues EG. Anti-metastatic immunotherapy based on mucosal administration of flagellin and immunomodulatory P10. Immunol Cell Biol. 2015 Jan;93(1):86-98.

de Melo Nunes R, Martins MR, da Silva Junior FS, de Melo Leite AC, Girão VC, de Queiroz Cunha F, Marinho AL, Pinto AC, Rocha FA. Strontium ranelate analgesia in arthritis models is associated to decreased cytokine release and opioid-dependent mechanisms. Inflamm Res. 2015 Oct;64(10):781-7.

Dias FC, Mendes-Junior CT, Silva MC, Tristão FS, Dellalibera-Joviliano R, Moreau P, Soares EG, Menezes JG, Schmidt A, Dantas RO, Marin-Neto JA, Silva JS, Donadi EA. Human leucocyte antigen-G (HLA-G) and its murine functional homolog Qa2 in the Trypanosoma cruzi Infection. Mediators Inflamm. 2015;2015:595829.

Fafá BP, Louzada-Junior P, Titton DC, Zandonade E, Ranza R, Laurindo I, Peçanha P, Ranzolin A, Hayata AL, Duarte A, Silveira IG, Costa I, Macieira JC, Guedes-Barbosa LS, Bertolo MB, Sauma MF, Silva MB, Freire M, Scheinberg MA, Fernandes V, Bianchi W, Miranda JR, Pinheiro GR, Carvalho HM, Brenol CV, Pereira IA, de Castro GR, de Morais JC, Oliveira SK, de Abreu MM, Toledo RA, Pinheiro MM, Vieira WP, Valim V. Drug survival and causes of discontinuation of the first anti-TNF in ankylosing spondylitis compared with rheumatoid arthritis: analysis from BIOBADABRASIL. Clin Rheumatol. 2015 May;34(5):921-7.

Fattori V, Pinho-Ribeiro FA, Borghi SM, Alves-Filho JC, Cunha TM, Cunha FQ, Casagrande R, Verri WA Jr. Curcumin inhibits superoxide anion-induced pain-like behavior and leukocyte recruitment by increasing Nrf2 expression and reducing NF-κB activation. Inflamm Res. 2015 Dec;64(12):993-1003.

Ferreira NS, Cau SB, Silva MA, Manzato CP, Mestriner FL, Matsumoto T, Carneiro FS, Tostes RC. Diabetes impairs the vascular effects of aldosterone mediated by G protein-coupled estrogen receptor activation. Front Pharmacol. 2015 Mar 2;6:34.

Fonseca MD, Cunha FQ, Kashfi K, Cunha TM. NOSH-aspirin (NBS-1120), a dual nitric oxide and hydrogen sulfide-releasing hybrid, reduces inflammatory pain. Pharmacol Res Perspect. 2015 Jun;3(3):e00133.

Franca R, Vieira SM, Talbot J, Peres RS, Pinto LG, Zamboni DS, Louzada-Junior P, Cunha FQ, Cunha TM. Expression and activity of NOD1 and NOD2/RIPK2 signalling in mononuclear cells from patients with rheumatoid arthritis. Scand J Rheumatol. 2015 Jul 45:8-12.

Freitas CS, Roveda AC Jr, Truzzi DR, Garcia AC, Cunha TM, Cunha FQ, Franco DW. Anti-inflammatory and Anti-nociceptive Activity of Ruthenium Complexes with Isonicotinic and Nicotinic Acids (Niacin) as Ligands. J Med Chem. 2015 Jun 11;58(11):4439-48.

Galvani RG, Lemos R, Areal RB, Salvador PA, Zamboni DS, Wanderley JL, Bonomo A. Disease severity and mortality can be independently regulated in a mouse model of experimental graft versus host disease. PLoS One. 2015 Feb 2;10(2):e0118079.

Gaspar-Elsas MI, Queto T, Masid-de-Brito D, Vieira BM, de Luca B, Cunha FQ, Xavier-Elsas P. α-Galactosylceramide suppresses murine eosinophil production through interferon-γ-dependent induction of NO synthase and CD95. Br J Pharmacol. 2015 Jul;172(13):3313-25.

Gonçalves L, Vieira J, Silva N, Santos C, Braga F, Costa J, Macêdo W, Silva C, Hage-Melim LI, Santos C. A QSAR Study of New Caffeine Derivatives with Epithelial Anticancer Activity. British Journal of Pharmaceutical Research, v. 7, p. 122-139, 2015.

Hagan T, Nakaya HI, Subramaniam S, Pulendran B. Systems vaccinology: Enabling rational vaccine design with. 2015 Sep 29;33(40):5294-301.

Ketelut-Carneiro N, Silva GK, Rocha FA, Milanezi CM, Cavalcanti-Neto FF, Zamboni DS, Silva JS. IL-18 triggered by the Nlrp3 inflammasome induces host innate resistance in a pulmonary model of fungal infection. J Immunol. 2015 May 1;194(9):4507-17.

Kian D, Lancheros CA, Damiani IA, Fernandes TZ, Pinge-Filho P, Santos MR, Silveira JF, Nakamura CV, Silva JS, Yamada-Ogatta SF, Yamauchi LM. Molecular Characterization of Trypanosoma cruzi Tc8.2 Gene Indicates Two Differential Locations for the Encoded Protein in Epimastigote and Trypomastigote Forms. Korean J Parasitol. 2015 Aug;53(4):483-8.

Leite CA, Alencar VT, Melo DL, Mota JM, Melo PH, Mourão LT, Wong DV, Magalhães PJ, Santos AA, Brito GA, Lima-Júnior RC, Cunha FQ, Ribeiro RA. Target Inhibition of IL-1 Receptor Prevents Ifosfamide Induced Hemorrhagic Cystitis in Mice. J Urol. 2015 Dec;194(6):1777-86.

Leite FR, de Aquino SG, Guimarães MR, Cirelli JA, Zamboni DS, Silva JS, Junior CR. Relevance of the myeloid differentiation factor 88 (MyD88) on RANKL, OPG, and nod expressions induced by TLR and IL-1R signaling in bone marrow stromal cells. Inflammation. 2015 Feb;38(1):1-8.

Lima CX, Souza DG, Amaral FA, Fagundes CT, Rodrigues IP, Alves-Filho JC, Kosco-Vilbois M, Ferlin W, Shang L, Elson G, Teixeira MM. Therapeutic Effects of Treatment with Anti-TLR2 and Anti-TLR4 Monoclonal Antibodies in Polymicrobial Sepsis. PLoS One. 2015 Jul 6;10(7):e0132336.

Lima LG, Bonardi JM, Campos GO, Bertani RF, Scher LM, Louzada-Junior P, Moriguti JC, Ferriolli E, Lima NK. Effect of aerobic training and aerobic and resistance training on the inflammatory status of hypertensive older adults. Aging Clin Exp Res. 2015 Aug;27(4):483-9.

Lisboa SF, Gomes FV, Silva AL, Uliana DL, Camargo LH, Guimarães FS, Cunha FQ, Joca SR, Resstel LB. Increased Contextual Fear Conditioning in iNOS Knockout Mice: Additional Evidence for the Involvement of Nitric Oxide in Stress-Related Disorders and Contribution of the Endocannabinoid System. Int J Neuropsychopharmacol. 2015 Jan 24;18(8). pii: pyv005.

Lopes AH, Talbot J, Silva RL, Lima JB, França RO, Verri WA Jr, Mascarenhas DP, Ryffel B, Cunha FQ, Zamboni DS, Cunha TM. Peripheral NLCR4 inflammasome participates in the genesis of acute inflammatory pain. Pain. 2015 Mar;156(3):451-9.

Lopes RA, Neves KB, Tostes RC, Montezano AC, Touyz RM. Downregulation of Nuclear Factor Erythroid 2-Related Factor and Associated Antioxidant Genes Contributes to Redox-Sensitive Vascular Dysfunction in Hypertension. Hypertension. 2015 Dec;66(6):1240-50.

Mascarenhas DP, Pereira MS, Manin GZ, Hori JI, Zamboni DS. Interleukin 1 receptor-driven neutrophil recruitment accounts to MyD88-dependent pulmonary clearance of legionella pneumophila infection in vivo. J Infect Dis. 2015 Jan 15;211(2):322-30.

Matsumoto T, Goulopoulou S, Taguchi K, Tostes RC, Kobayashi T. Constrictor prostanoids and uridine adenosine tetraphosphate: vascular mediators and therapeutic targets in hypertension and diabetes. Br J Pharmacol. 2015 Aug;172(16):3980-4001.

Molinaro R, Pecli C, Guilherme RF, Alves-Filho JC, Cunha FQ, Canetti C, Kunkel SL, Bozza MT, Benjamim CF. CCR4 Controls the Suppressive Effects of Regulatory T Cells on Early and Late Events during Severe Sepsis. PLoS One. 2015 Jul 21;10(7):e0133227.

Moreira JD, Pernomian L, Gomes MS, Pernomian L, Moreira RP, do Prado AF, da Silva CH, de Oliveira AM. Acute restraint stress increases carotid reactivity in type-I diabetic rats by enhancing Nox4/NADPH oxidase functionality. Eur J Pharmacol. 2015 Oct 15;765:503-16.

Mota LM, Cruz BA, Brenol CV, Pollak DF, Pinheiro Gda R, Laurindo IM, Pereira IA, Carvalho JF, Bertolo MB, Pinheiro Mde M, Freitas MV, Silva NA, Louzada-Júnior P, Sampaio-Barros PD, Giorgi RD, Lima RA, Andrade LE. [Safe use of biological therapies for the treatment of rheumatoid arthritis and spondyloarthritides]. Rev Bras Reumatol. 2015 May-Jun;55(3):281-309.

Mota LM, Cruz BA, Brenol CV, Pollak DF, Pinheiro GR, Laurindo IM, Pereira IA, Carvalho JF, Bertolo MB, Pinheiro MM, Freitas MV, Silva NA, Louzada-Júnior P, Sampaio PD, Giorgi RD, Lima RA, Andrade LE. Segurança do uso de terapias biológicas para o tratamento de artrite reumatoide e espondiloartrites. Revista Brasileira de Reumatologia (Impresso). 2015;55:281-309.

Moura JF, Mota JM, Leite CA, Wong DV, Bezerra NP, Brito GA, Lima V, Cunha FQ, Ribeiro RA. A novel model of megavoltage radiation-induced oral mucositis in hamsters: Role of inflammatory cytokines and nitric oxide. Int J Radiat Biol. 2015 Jun;91(6):500-9.

Nakaya HI, Bruna-Romero O. Is the gut microbiome key to modulating vaccine efficacy? Expert Rev Vaccines. 2015 Jun;14(6):777-9.

Nakaya HI, Hagan T, Duraisingham SS, Lee EK, Kwissa M, Rouphael N, Frasca D, Gersten M, Mehta AK, Gaujoux R, Li GM, Gupta S, Ahmed R, Mulligan MJ, Shen-Orr S, Blomberg BB, Subramaniam S, Pulendran B. Systems Analysis of Immunity to Influenza Vaccination across Multiple Years and in Diverse Populations Reveals Shared Molecular Signatures. Immunity. 2015 Dec 15;43(6):1186-98.

Nakaya HI, Pulendran B. Vaccinology in the era of high-throughput biology. Philos Trans R Soc Lond B Biol Sci. 2015 Jun 19;370(1671). pii: 20140146.

Nascimento MS, Carregaro V, Lima-Júnior DS, Costa DL, Ryffel B, Duthie MS, de Jesus A, de Almeida RP, da Silva JS. Interleukin 17A acts synergistically with interferon γ to promote protection against Leishmania infantum infection. J Infect Dis. 2015 Mar 15;211(6):1015-26.

Navarro IC, Ferreira FM, Nakaya HI, Baron MA, Vilar-Pereira G, Pereira IR, Silva AM, Real JM, De Brito T, Chevillard C, Lannes-Vieira J, Kalil J, Cunha-Neto E, Ferreira LR. MicroRNA Transcriptome Profiling in Heart of Trypanosoma cruzi-Infected Mice: Parasitological and Cardiological Outcomes. PLoS Negl Trop Dis. 2015 Jun 18;9(6):e0003828.

Neves KB, Nguyen Dinh Cat A, Lopes RA, Rios FJ, Anagnostopoulou A, Lobato NS, de Oliveira AM, Tostes RC, Montezano AC, Touyz RM. Chemerin Regulates Crosstalk Between Adipocytes and Vascular Cells Through Nox. Hypertension. 2015 Sep;66(3):657-66.

Parra RS, Lopes AH, Carreira EU, Feitosa MR, Cunha FQ, Garcia SB, Cunha TM, da Rocha JJ, Féres O. Hyperbaric oxygen therapy ameliorates TNBS-induced acute distal colitis in rats. Med Gas Res. 2015 Apr 16;5:6.

Patricio ES, Costa R, Figueiredo CP, Gers-Barlag K, Bicca MA, Manjavachi MN, Segat GC, Gentry C, Luiz AP, Fernandes ES, Cunha TM, Bevan S, Calixto JB. Mechanisms Underlying the Scratching Behavior Induced by the Activation of Proteinase-Activated Receptor-4 in Mice. J Invest Dermatol. 2015 Oct;135(10):2484-91.

Pereira CA, Ferreira NS, Mestriner FL, Antunes-Rodrigues J, Evora PR, Resstel LB, Carneiro FS, Tostes RC. Chronic fluoxetine treatment increases NO bioavailability and calcium-sensitive potassium channels activation in rat mesenteric resistance arteries. Eur J Pharmacol. 2015 Oct 15;765:375-83.

Peres RS, Liew FY, Talbot J, Carregaro V, Oliveira RD, Almeida SL, França RF, Donate PB, Pinto LG, Ferreira FI, Costa DL, Demarque DP, Gouvea DR, Lopes NP, Queiroz RH, Silva JS, Figueiredo F, Alves-Filho JC, Cunha TM, Ferreira SH, Louzada-Junior P, Cunha FQ. Low expression of CD39 on regulatory T cells as a biomarker for resistance to methotrexate therapy in rheumatoid arthritis. Proc Natl Acad Sci U S A. 2015 Feb 24;112(8):2509-14.

Pernomian L, da Silva CH. Current basis for discovery and development of aryl hydrocarbon receptor antagonists for experimental and therapeutic use in atherosclerosis. Eur J Pharmacol. 2015 Oct 5;764:118-23.

Pernomian L, do Prado AF, Gomes MS, Pernomian L, da Silva CH, Gerlach RF, de Oliveira AM. MAS receptors mediate vasoprotective and atheroprotective effects of candesartan upon the recovery of vascular angiotensin-converting enzyme 2-angiotensin-(1-7)-MAS axis functionality. Eur J Pharmacol. 2015 Oct 5;764:173-88.

Pernomian L, Pernomian L, Gomes MS, da Silva CH. Pharmacological significance of the interplay between angiotensin receptors: MAS receptors as putative final mediators of the effects elicited by angiotensin AT1 receptors antagonists. Eur J Pharmacol. 2015 Dec 15;769:143-6.

Picanço L, Castro L, Pinheiro A, Silva K, Souza L, Braga F, Silva C, Santos C, Hage-Melim LI. Study of Molecular Docking, Physicochemical and Pharmacokinetic Properties of GSK-3β Inhibitors. British Journal of Pharmaceutical Research, v. 7, p. 152-175, 2015.

Pinheiro AA, Silva KR, Silva AE, Braga FS, Silva CH, Santos CB, Hage-Melim LI. In silico Identification of Novel Potential BACE-1 Inhibitors for Alzheimer?s Disease Treatment: Molecular Docking, Pharmacophore Modeling and Activity and Synthetic Accessibility Predictions. British Journal of Pharmaceutical Research, v. 7, p. 217-229, 2015.

Pinto LG, Talbot J, Peres RS, Franca RF, Ferreira SH, Ryffel B, Aves-Filho JC, Figueiredo F, Cunha TM, Cunha FQ. Joint production of IL-22 participates in the initial phase of antigen-induced arthritis through IL-1β production. Arthritis Res Ther. 2015 Sep 2;17:235.

Quadros AU, Pinto LG, Fonseca MM, Kusuda R, Cunha FQ, Cunha TM. Dynamic weight bearing is an efficient and predictable method for evaluation of arthritic nociception and its pathophysiological mechanisms in mice. Sci Rep. 2015 Oct 29;5:14648.

Ramos-Junior ES, Morandini AC, Almeida-da-Silva CL, Franco EJ, Potempa J, Nguyen KA, Oliveira AC, Zamboni DS, Ojcius DM, Scharfstein J, Coutinho-Silva R. A Dual Role for P2X7 Receptor during Porphyromonas gingivalis Infection. J Dent Res. 2015 Sep;94(9):1233-42.

Ranza R, Laurindo I, Titton D, Barbosa L, Bertolo M, Bertaccini J, Brenol C, Carvalho H, Castro G, Cecconi M, Costa I, Duarte A, Fernandes V, Freire M, Louzada P, Macieira J, Miranda J, Pereira I, Pinheiro G, Pinheiro M, Sauma M, Silva M, Toledo R, Valin V, Vieira W, et al. SAT0362-Incidence of Adverse Events in Patients with Rheumatoid Arthritis and Spondyloarthritis Exposed to Anti-Tnf Therapy. Annals of the Rheumatic Diseases. 2015;74:790.2-790

Rodrigues FL, Fais RS, Tostes RC, Carneiro FS. There is a link between erectile dysfunction and heart failure: it could be inflammation. Curr Drug Targets. 2015;16(5):442-50.

Rodrigues FL, Silva LE, Hott SC, Bomfim GF, da Silva CA, Fazan R Jr, Resstel LB, Tostes RC, Carneiro FS. Toll-like receptor 9 plays a key role in the autonomic cardiac and baroreflex control of arterial pressure. Am J Physiol Regul Integr Comp Physiol. 2015 Apr 15;308(8):R714-23.

Rondinoni C, Zanatta DP, Souza-Zinader J, Louzada Junior P, Menezes PR, Santos AC, Del-Ben CM. P.3.f.024 Tract-based statistics in first episode psychosis: preliminary results depending on substance abuse comorbidity. European Neuropsychopharmacology. 2015;25:S549-S550.

Ruiz-Miyazawa KW, Pinho-Ribeiro FA, Zarpelon AC, Staurengo-Ferrari L, Silva RL, Alves-Filho JC, Cunha TM, Cunha FQ, Casagrande R, Verri WA Jr. Vinpocetine reduces lipopolysaccharide-induced inflammatory pain and neutrophil recruitment in mice by targeting oxidative stress, cytokines and NF-κB. Chem Biol Interact. 2015 Jul 25;237:9-17.

Sacramento L, Trevelin SC, Nascimento MS, Lima-Jùnior DS, Costa DL, Almeida RP, Cunha FQ, Silva JS, Carregaro V. Toll-like receptor 9 signaling in dendritic cells regulates neutrophil recruitment to inflammatory foci following Leishmania infantum infection. Infect Immun. 2015 Dec;83(12):4604-16.

Santos CB, Lobato CC, Braga FS, Costa Jda S, Favacho HA, Carvalho JC, Macedo WJ, Brasil Ddo S, Silva CH, Silva Hage-Melim LI. Rational Design of Antimalarial Drugs Using Molecular Modeling and Statistical Analysis. Curr Pharm Des. 2015;21(28):4112-27.

Santos CB, Lobato CC, Braga FS, Costa JS, Favacho HA, Carvalho JC, Macedo WJ, Brasil DS, Silva CH, Hage-Melim LI. Rational Design of Antimalarial Drugs Using Molecular Modeling and Statistical Analysis. Current Pharmaceutical Design (Print), v. 21, p. 4112-4127, 2015.

Serafim KG, Navarro SA, Zarpelon AC, Pinho-Ribeiro FA, Fattori V, Cunha TM, Alves-Filho JC, Cunha FQ, Casagrande R, Verri WA Jr. Bosentan, a mixed endothelin receptor antagonist, inhibits superoxide anion-induced pain and inflammation in mice. Naunyn Schmiedebergs Arch Pharmacol. 2015 Nov;388(11):1211-21. s vascular dysfunction in type 2 diabetic mice by decreasing oxidative stress and restoring NO/GC signaling. Front Physiol. 2015 Oct 5;6:269.

Silva MA, Cau SB, Lopes RA, Manzato CP, Neves KB, Bruder-Nascimento T, Mestriner FL, Montezano AC, Nguyen Dinh Cat A, Touyz RM, Tostes RC. Mineralocorticoid receptor blockade prevents vascular remodelling in a rodent model of type 2 diabetes mellitus. Clin Sci (Lond). 2015 Oct;129(7):533-45.

Silva NS, Santos CF, Goncalves LK, Braga FS, Silva RC, Costa JS, Silva CH, Brasil DS, Hage-Melim LI, Santos CB. Molecular Modeling of the Major Compounds of Sesquiterpenes Class in Copaiba Oil-resin. British Journal of Pharmaceutical Research, v. 7, p. 247-263, 2015.

Silva RL, Lopes AH, França RO, Vieira SM, Silva EC, Amorim RC, Cunha FQ, Pohlit AM, Cunha TM. The quassinoid isobrucein B reduces inflammatory hyperalgesia and cytokine production by post-transcriptional modulation. J Nat Prod. 2015 Feb 27;78(2):241-9.

Souza GR, Cunha TM, Silva RL, Lotufo CM, Verri WA Jr, Funez MI, Villarreal CF, Talbot J, Sousa LP, Parada CA, Cunha FQ, Ferreira SH. Involvement of nuclear factor kappa B in the maintenance of persistent inflammatory hypernociception. Pharmacol Biochem Behav. 2015 Jul;134:49-56.

Talbot J, Bianchini FJ, Nascimento DC, Oliveira RD, Souto FO, Pinto LG, Peres RS, Silva JR, Almeida SC, Louzada-Junior P, Cunha TM, Cunha FQ, Alves-Filho JC. CCR2 Expression in Neutrophils Plays a Critical Role in Their Migration Into the Joints in Rheumatoid Arthritis. Arthritis Rheumatol. 2015 Jul;67(7):1751-9.

Toller-Kawahisa JE, Canicoba NC, Venancio VP, Kawahisa R, Antunes LM, Cunha TM, Marzocchi-Machado CM. Systemic lupus erythematosus onset in lupus-prone B6.MRL/lpr mice Is influenced by weight gain and Is preceded by an increase in neutrophil oxidative burst activity. Free Radic Biol Med. 2015 Sep;86:362-73.

Uren PJ, Vo DT, de Araujo PR, Pötschke R, Burns SC, Bahrami-Samani E, Qiao M, de Sousa Abreu R, Nakaya HI, Correa BR, Kühnöl C, Ule J, Martindale JL, Abdelmohsen K, Gorospe M, Smith AD, Penalva LO. RNA-Binding Protein Musashi1 Is a Central Regulator of Adhesion Pathways in Glioblastoma. Mol Cell Biol. 2015 Sep 1;35(17):2965-78.

Vaz ER, Fujimura PT, Araujo GR, da Silva CA, Silva RL, Cunha TM, Lopes-Ferreira M, Lima C, Ferreira MJ, Cunha-Junior JP, Taketomi EA, Goulart LR, Ueira-Vieira C. A Short Peptide That Mimics the Binding Domain of TGF-β1 Presents Potent Anti-Inflammatory Activity. PLoS One. 2015 Aug 27;10(8):e0136116.

Veras FP, Peres RS, Saraiva AL, Pinto LG, Louzada-Junior P, Cunha TM, Paschoal JA, Cunha FQ, Alves-Filho JC. Fructose 1,6-bisphosphate, a high-energy intermediate of glycolysis, attenuates experimental arthritis by activating anti-inflammatory adenosinergic pathway. Sci Rep. 2015 Oct 19;5:15171.

Wong DV, Lima-Júnior RC, Carvalho CB, Borges VF, Wanderley CW, Bem AX, Leite CA, Teixeira MA, Batista GL, Silva RL, Cunha TM, Brito GA, Almeida PR, Cunha FQ, Ribeiro RA. The Adaptor Protein Myd88 Is a Key Signaling Molecule in the Pathogenesis of Irinotecan-Induced Intestinal Mucositis. PLoS One. 2015 Oct 6;10(10):e0139985.

Xavier-Elsas P, de Luca B, Queto T, Vieira BM, Masid-de-Brito D, Dahab EC, Alves Filho JC, Cunha FQ, Gaspar-Elsas MI. Blockage of Eosinopoiesis by IL-17A Is Prevented by Cytokine and Lipid Mediators of Allergic Inflammation. Mediators Inflamm. 2015;2015:968932.

Yamacita-Borin FY, Zarpelon AC, Pinho-Ribeiro FA, Fattori V, Alves-Filho JC, Cunha FQ, Cunha TM, Casagrande R, Verri WA Jr. Superoxide anion-induced pain and inflammation depends on TNFα/TNFR1 signaling in mice. Neurosci Lett. 2015 Sep25;605:53-8.

Zamboni DS, Lima-Junior DS. Inflammasomes in host response to protozoan parasites. Immunol Rev. 2015 May;265(1):156-71.


• AGE-MELIM, L. I. S. ; SANTOS, C. B. R. ; POIANI, J. G. C. ; VAIDERGOM, M. M. ; MANZOLLI, E. S. ; Silva, C.H.T.P. . Computational Medicinal Chemistry to Design Novel Phosphoinositide 3- Kinase (PI3K) Alpha Inhibitors in View of Cancer. Current Bioactive Compounds, v. 10, p. 147-157, 2014.

• Aguiar CJ, Rocha-Franco JA, Sousa PA, Santos AK, Ladeira M, Rocha-Resende C, Ladeira LO, Resende RR, Botoni FA, Barrouin Melo M, Lima CX, Carballido JM, Cunha TM, Menezes GB, Guatimosim S, Leite MF. Succinate causes pathological cardiomyocyte hypertrophy through GPR91 activation. Cell Commun Signal. 2014 Dec 24;12:78.

• Araújo JG Rodrigues RP, Federico LB, Silva CHTP. Structure-Based Drug Design of Novel MARK-3 Inhibitors in Cancer. Current Bioactive Compounds, v. 10, p. 131-138, 2014.

• Araújo JG, Almeida JR, Poiani JGC, Taft CA, Silva CHTP. Ligand-Based Drug Design of Novel MARK-3 Inhibitors in Cancer. Current Bioactive Compounds, v. 10, p. 112-123, 2014.

• ATAIDE, MARCO A. ; ANDRADE, WARRISON A. ; Zamboni, Dario S. ; WANG, DONGHAI ; SOUZA, MARIA DO CARMO ; FRANKLIN, BERNARDO S. ; ELIAN, SAMIR ; MARTINS, FLAVIANO S. ; PEREIRA, DHELIO ; REED, GEORGE ; FITZGERALD, KATHERINE A. ; GOLENBOCK, DOUGLAS T. ; Gazzinelli, Ricardo T. . Malaria-Induced NLRP12/NLRP3-Dependent Caspase-1 Activation Mediates Inflammation and Hypersensitivity to Bacterial Superinfection. PLoS Pathogens (Online), v. 10, p. e1003885, 2014.

• BARBOSA, ANDRÉ LUIZ DOS REIS ; DE SOUSA, RHAMON BARROSO ; TORRES, JOÃO NATHANAEL LIMA ; Cunha, Thiago Mattar ; CUNHA, FERNANDO DE QUEIROZ ; SOARES, PEDRO MARCOS GOMES ; RIBEIRO, RONALDO DE ALBUQUERQUE ; VALE, MARIANA LIMA ; SOUZA, MARCELLUS HENRIQUE LOIOLA PONTE . Colitis generates remote antinociception in rats: the role of the l-arginine/NO/cGMP/PKG/KATP pathway and involvement of cannabinoid and opioid systems. Inflammation Research (Printed ed.), v. 63, p. 969-977, 2014.

• Barbour M, Allan D, Xu H, Pei C, Chen M, Niedbala W, Fukada SY, Besnard AG, Alves-Filho JC, Tong X, Forrester JV, Liew FY, Jiang HR. IL-33 attenuates the development of experimental autoimmune uveitis. Eur J Immunol. 2014 Nov;44(11):3320-9.

• BARRAGÁN-IGLESIAS, PAULINO; ROCHA-GONZÁLEZ, HECTOR I.; PINEDA-FARIAS, JORGE BARUCH; MURBARTIÁN, JANET; GODÍNEZ-CHAPARRO, BEATRIZ; REINACH, PETER S.; CUNHA, THIAGO M.; CUNHA, FERNANDO Q.; GRANADOS-SOTO, VINICIO. Inhibition of peripheral anion exchanger 3 decreases formalin-induced pain. European Journal of Pharmacology , v. 738C, p. 91-100, 2014.

• BELAI, E. B.; DE OLIVEIRA, C. E.; GASPAROTO, T. H.; RAMOS, R. N. ; TORRES, S. A.; GARLET, G. P.; CAVASSANI, K. A.; SILVA, J. S.; CAMPANELLI, A. P.. PD-1 blockage delays murine squamous cell carcinoma development. Carcinogenesis (New York. Print) , v. 35, p. 424-431, 2014.

• Bonfá G, Benevides L, Souza Mdo C, Fonseca DM, Mineo TW, Rossi MA, Silva NM, Silva JS, de Barros Cardoso CR. CCR5 controls immune and metabolic functions during Toxoplasma gondii infection. PLoS One. 2014 Aug 13;9(8):e104736.

• BORGHI, SERGIO M.; ZARPELON, ANA C.; PINHO-RIBEIRO, FELIPE A.; CARDOSO, RENATO D.R.; MARTINS-PINGE, MARLI C.; TATAKIHARA, ROBERTO I.; CUNHA, THIAGO M.; FERREIRA, SERGIO H.; CUNHA, FERNANDO Q.; CASAGRANDE, RUBIA; VERRI, WALDICEU A.. Role of TNF-α/TNFR1 in Intense Acute Swimming-induced Delayed Onset Muscle Soreness in Mice. Physiology & Behavior , v. 128, p. 277-287, 2014.

• BORGHI, SERGIO M.; ZARPELON, ANA C.; PINHO-RIBEIRO, FELIPE A.; CARDOSO, RENATO D. R.; CUNHA, THIAGO M.; ALVES-FILHO, JOSÉ C.; FERREIRA, SERGIO H.; CUNHA, FERNANDO Q.; CASAGRANDE, RUBIA; VERRI, WALDICEU A.. Targeting interleukin-1β reduces intense acute swimming-induced muscle mechanical hyperalgesia in mice. Journal of Pharmacy and Pharmacology , v. 66, p. 1009-1020, 2014.

• Bruder-Nascimento T, da Silva MA, Tostes RC. The involvement of aldosterone on vascular insulin resistance: implications in obesity and type 2 diabetes. Diabetol Metab Syndr. 2014 Aug 24;6(1):90.

• BRUDER-NASCIMENTO, T.; CHINNASAMY, P.; RIASCOS-BERNAL, D.F.; CAU, S.B.; CALLERA, G.E.; TOUYZ, R.M.; TOSTES, R.C.; SIBINGA, N.E.S.. Angiotensin II induces Fat1 expression/activation and vascular smooth muscle cell migration via Nox1-dependent reactive oxygen species generation. Journal of Molecular and Cellular Cardiology , v. 66, p. 18-26, 2014.

• CALIL, IGOR L.; ZARPELON, A. C.; GUERRERO, ANA T. G.; ALVES-FILHO, JOSE C.; FERREIRA, S. H.; CUNHA, FERNANDO Q.; CUNHA, THIAGO M.; VERRI, WALDICEU A.. Lipopolysaccharide Induces Inflammatory Hyperalgesia Triggering a TLR4/MyD88-Dependent Cytokine Cascade in the Mice Paw. Plos One , v. 9, p. e90013, 2014.

• Canavaci AM, Sorgi CA, Martins VP, Morais FR, de Sousa ÉV, Trindade BC, Cunha FQ, Rossi MA, Aronoff DM, Faccioli LH, Nomizo A. The acute phase of Trypanosoma cruzi infection is attenuated in 5-lipoxygenase-deficient mice. Mediators Inflamm. 2014;2014:893634.

• CARNEIRO, ZUMIRA A.; DA S. MAIA, PEDRO I.; SESTI-COSTA, RENATA; LOPES, CARLA D.; PEREIRA, TATIANA A.; MILANEZI, CRISTIANE M.; DA SILVA, MARCELO A. PEREIRA.; LOPEZ, RENATA F. V.; SILVA, JOÃO S.; DEFLON, VICTOR M. . In Vitro and In Vivo Trypanocidal Activity of H2bdtc-Loaded Solid Lipid Nanoparticles. PLoS Neglected Tropical Diseases (Online) , v. 8, p. e2847, 2014.

• Ceravolo GS, Montezano AC, Jordão MT, Akamine EH, Costa TJ, Takano AP, Fernandes DC, Barreto-Chaves ML, Laurindo FR, Tostes RC, Fortes ZB, Chopard RP,Touyz RM, Carvalho MH. An interaction of renin-angiotensin and kallikrein-kinin systems contributes to vascular hypertrophy in angiotensin II-induced hypertension: in vivo and in vitro studies. PLoS One. 2014 Nov 4;9(11)


• Cunha LD, Zamboni DS. Recognition of Legionella pneumophila nucleic acids by innate immune receptors. Microbes Infect. 2014 Dec;16(12):985-90.

• DE AQUINO, S. G.; ABDOLLAHI-ROODSAZ, S.; KOENDERS, M. I.; VAN DE LOO, F. A. J.; PRUIJN, G. J. M.; MARIJNISSEN, R. J.; WALGREEN, B.; HELSEN, M. M.; VAN DEN BERSSELAAR, L. A.; DE MOLON, R. S.; CAMPOS, M. J. A. ; CUNHA, F. Q.; CIRELLI, J. A.; VAN DEN BERG, W. B.. Periodontal Pathogens Directly Promote Autoimmune Experimental Arthritis by Inducing a TLR2- and IL-1-Driven Th17 Response. The Journal of Immunology (1950), v. 192, p. 1-9, 2014.

• de Melo Leite AC, Teotonio MA, Girão VC, de Lima Pompeu MM, de Melo Nunes R, Cunha TM, Pinto AC, de Queiroz Cunha F, Rocha FA. Meniscal transection rather than excision increases pain behavior and structural damage in experimental osteoarthritis in mice. Osteoarthritis Cartilage. 2014 Nov;22(11):1878-85.

• DE MELO, FILIPE M ; BRAGA, CATARINA JM ; PEREIRA, FELIPE V ; MARICATO, JULIANA T ; ORIGASSA, CLARICE ST ; SOUZA, MARIANA F ; MELO, AMANDA C ; SILVA, PRISCILA ; TOMAZ, SAMANTA L ; GIMENES, KARINA P ; SCUTTI, JORGE AB ; JULIANO, MARIA A ; ZAMBONI, DARIO S ; CÂMARA, NIELS O ; TRAVASSOS, LUIZ R ; FERREIRA, LUIS CS ; RODRIGUES, ELAINE G . Anti-metastatic immunotherapy based on mucosal administration of flagellin and mmunomodulatory P10. Immunology and Cell Biology (Print), v. 93, p. 86-98, 2014.

• Dutra FF, Alves LS, Rodrigues D, Fernandez PL, de Oliveira RB, Golenbock DT, Zamboni DS, Bozza MT. Hemolysis-induced lethality involves inflammasome activation by heme. Proc Natl Acad Sci U S A. 2014 Sep 30;111(39):E4110-8.

• Faustino L, Fonseca DM, Florsheim EB, Resende RR, Lepique AP, Faquim-Mauro E, Gomes E, Silva JS, Yagita H, Russo M. Tumor necrosis factor-related apoptosis-inducing ligand mediates the resolution of allergic airway inflammation induced by chronic allergen inhalation. Mucosal Immunol. 2014 Sep;7(5):1199-208.

• FERREIRA, F. P.; COUTO, W. F.; FONTANA, V.; SILVA, C. H. T. P.. Molecular dynamics, density functional theory, pharmacophore modeling, molecular interaction fields and ADME/Tox investigation of novel bioactive compounds interaction with CDK2 surfaces.. Current Physical Chemistry, v. 4, p. 94-105, 2014.

• FIGUEIREDO, SÔNIA APARECIDA; VILELA, FERNANDA MARIA PINTO; DA SILVA, CLAUDINEI ALVES; CUNHA, THIAGO MATTAR; DOS SANTOS, MARCELO HENRIQUE; FONSECA, MARIA JOSÉ VIEIRA. In Vitro and In Vivo Photoprotective/Photochemopreventive Potential of Garcinia brasiliensis Epicarp Extract. Journal of Photochemistry and Photobiology. B, Biology , v. 131, p. 65-73, 2014.

• GARRIDO-SUÁREZ, BÁRBARA B.; GARRIDO, GABINO; CASTRO-LABRADA, MARIAN; MERINO, NELSON; VALDÉS, ODALYS; RODEIRO, IDANIA; HERNÁNDEZ, IVONNES; GODOY-FIGUEREIDO, JOZI; FERREIRA, SERGIO H.; DELGADO-HERNÁNDEZ, RENÉ. Anti-hypernociceptive effect of mangiferin in persistent and neuropathic pain models in rats. Pharmacology, Biochemistry and Behavior , v. 1, p. 10-0, 2014.

• Gasparoto TH, de Oliveira CE, de Freitas LT, Pinheiro CR, Hori JI, Garlet GP, Cavassani KA, Schillaci R, da Silva JS, Zamboni DS, Campanelli AP. Inflammasome activation is critical to the protective immune response during chemically induced squamous cell carcinoma. PLoS One. 2014 Sep 30;9(9):e107170.

• Gasparoto TH, de Souza Malaspina TS, Damante JH, de Mello EF Jr, Ikoma MR, Garlet GP, Costa MR, Cavassani KA, da Silva JS, Campanelli AP. Regulatory T cells in the actinic cheilitis. J Oral Pathol Med. 2014 Nov;43(10):754-60.

• GIACHINI, FERNANDA R.; LEITE, ROMULO; OSMOND, DAVID A.; LIMA, V. V.; INSCHO, EDWARD W.; WEBB, R. CLINTON; TOSTES RC. Anti-Platelet Therapy with Clopidogrel Prevents Endothelial Dysfunction and Vascular Remodeling in Aortas from Hypertensive Rats. Plos One , v. 9, p. e91890, 2014.

• GUABIRABA, R; BESNARD, A G; MENEZES, G B; SECHER, T; JABIR, M S ; AMARAL, S S; BRAUN, H ; LIMA-JUNIOR, R CP; RIBEIRO, R A; CUNHA, F Q; TEIXEIRA, M M; BEYAERT, R; GRAHAM, G J; LIEW, F Y . IL-33 targeting attenuates intestinal mucositis and enhances effective tumor chemotherapy in mice. Mucosal Immunology , v. 15-01, p. 01-15, 2014.

• Gutierrez FR, Sesti-Costa R, Silva GK, Trujillo ML, Guedes PM, JS.Silva Regulation of the immune response during infectious myocarditis. Expert Rev Cardiovasc Ther. 2014 Feb;12(2):187-200.

• HERNANDES, MARINA S ; D AVILA, JOANA C; TREVELIN, SILVIA C ; REIS, PATRICIA A; KINJO, ERIKA R; LOPES, LUCIA R; CASTRO-FARIA-NETO, HUGO C; CUNHA, FERNANDO Q; BRITTO, LUIZ RG; BOZZA, FERNANDO A. The role of Nox2-derived ROS in the development of cognitive impairment after sepsis. Journal of Neuroinflammation , v. 11, p. 36-48, 2014.

• IVAN, ANA L.M.; CAMPANINI, MARCELA Z.; MARTINEZ, RENATA M.; FERREIRA, VITOR S.; STEFFEN, VINICIUS S.; VICENTINI, FABIANA T.M.C.; VILELA, FERNANDA M.P.; MARTINS, FREDERICO SEVERINO; ZARPELON, ANA C.; CUNHA, THIAGO M.; FONSECA, MARIA J.V.; BARACAT, MARCELA M.; GEORGETTI, SANDRA R.; VERRI, WALDICEU A.; CASAGRANDE, RÚBIA. Pyrrolidine dithiocarbamate inhibits UVB-induced skin inflammation and oxidative stress in hairless mice and exhibits antioxidant activity in vitro. Journal of Photochemistry and Photobiology. B, Biology , v. 138, p. 124-133, 2014.

• Junqueira GG, Carvalho MR, Andrade P, Lopes CD, Carneiro ZA, Sesti-Costa R, Silva JS, Carvalho I. Synthesis and in vitro Evaluation of Novel Glactosyl-triazolo-benzenesulfonamides Against Trypanossoma cruzi. J.Braz.Chem.Soc, 25: p.1872-1884, 2014

• KÜPPER, DANIEL SALGADO; VALERA, FABIANA C. P.; MALINSKY, RAFAEL; MILANEZI, CRISTIANE MARIA; SILVA, JOÃO S.; TAMASHIRO, EDWIN; ANSELMO-LIMA, WILMA T.. Expression of apoptosis mediators p53 and caspase 3, 7, and 9 in chronic rhinosinusitis with nasal polyposis. American Journal of Rhinology & Allergy (Print) , v. 28, p. 187-191, 2014.

• LEITE, FÁBIO RENATO MANZOLLI ; DE AQUINO, SABRINA GARCIA ; GUIMARÃES, MORGANA RODRIGUES ; CIRELLI, JONI AUGUSTO ; Zamboni, Dario S. ; Silva, João S. ; JUNIOR, CARLOS ROSSA . Relevance of the Myeloid Differentiation Factor 88 (MyD88) on RANKL, OPG, and Nod Expressions Induced by TLR and IL-1R Signaling in Bone Marrow Stromal Cells. Inflammation, v. 38, p. 1, 2014.

• LIMA, V. V. ; LOBATO, N.S. ; FILGUEIRA, F.P. ; Webb, R.C. ; TOSTES RC ; GIACHINI, F.R. . Vascular O-GlcNAcylation augments reactivity to constrictor stimuli by prolonging phosphorylated levels of the myosin light chain. Brazilian journal of medical and biological research, v. 47, p. 826-833, 2014.

• LIMA-JÚNIOR, R C P; FREITAS, H C; WONG, D V T; WANDERLEY, C W S; NUNES, L G; LEITE, L L; MIRANDA, S P; SOUZA, M H L P; BRITO, G A C; MAGALHÃES, P J C; TEIXEIRA, M M; CUNHA, F Q; RIBEIRO, R A. Targeted Inhibition of Interleukin-18 Attenuates Irinotecan-Induced Intestinal Mucositis in Mice. British Journal of Pharmacology , v. 171, p. n/a-n/a, 2014.

• LOPES, R. A. M.; NEVES, K. B.; PESTANA, C. R.; QUEIROZ, A. L.; ZANOTTO, C. Z.; CHIGNALIA, A. Z.; VALIM, Y. M.; SILVEIRA, L. R.; CURTI, C.; TOSTES, R. C.. Testosterone induces apoptosis in vascular smooth muscle cells via extrinsic apoptotic pathway with mitochondria-generated reactive oxygen species involvement. American Journal of Physiology. Heart and Circulatory Physiology , v. 306, p. h1485-h1494, 2014.

• Louzada-Junior P. ScienceDirect: the indexation which RBR lacked. Rev Bras Reumatol. 2014 May-Jun;54(3):165.

• LOUZADA’JUNIOR, PAULO . ScienceDirect: a indexação que faltava à RBR. Revista Brasileira de Reumatologia (Impresso), v. 54, p. 165, 2014.

• Macedo, Claudia ; OLIVEIRA, ERNNA H. ; ALMEIDA, RENATA S. ; CUNHA, F. Q. ; FORNARI, T. A. ; PEZZI, NICOLE ; Sakamoto-Hojo, Elza T. ; Donadi, Eduardo A. ; Passos, Geraldo A. . Aire-dependent peripheral tissue antigen mRNAs in mTEC cells feature networking refractoriness to microRNA interaction. Immunobiology (Jena. 1979), v. 14, p. 93-102, 2014.

• MALVAR, DAVID DO C.; AGUIAR, FERNANDO A.; VAZ, ARTUR DE L. L.; ASSIS, DÉBORA C. R.; DE MELO, MIRIAM C. C.; JABOR, VALQUÍRIA A. P.; KALAPOTHAKIS, EVANGUEDES; FERREIRA, SÉRGIO H.; CLOSOSKI, GIULIANO C.; DE SOUZA, GLÓRIA E.P.. The dipyrone metabolite 4-MAA induces hypothermia and inhibits PGE 2 -dependent and-independent fever while 4-AA only blocks PGE 2 -dependent fever. British Journal of Pharmacology , v. 1, p. n/a-n/a, 2014.

• Malvestio LM, Celes MR, Milanezi C, Silva JS, Jelicks LA, Tanowitz HB, Rossi MA, Prado CM. Role of dystrophin in acute Trypanosoma cruzi infection. Microbes Infect. 2014 Sep;16(9):768-77.

• MANTOANI, S. P.; SILVA, V. B.; SILVA, C. H. T. P.. Pharmacophore-based drug design of novel potential tau ligands for Alzheimer’s disease treatment.. Current Physical Chemistry, v. 4, p. 35-44, 2014.

• MATSUMOTO, TAKAYUKI; LOPES, RHEURE A.M.; TAGUCHI, KUMIKO; KOBAYASHI, TSUNEO; TOSTES, RITA C.. Linking the beneficial effects of current therapeutic approaches in diabetes to the vascular endothelin system. Life Sciences (1973) , v. 14, p. 11-13, 2014.

• Moriconi A, Cunha TM, Souza GR, Lopes AH, Cunha FQ, Carneiro VL, Pinto LG, Brandolini L, Aramini A, Bizzarri C, Bianchini G, Beccari AR, Fanton M, Bruno A, Costantino G, Bertini R, Galliera E, Locati M, Ferreira SH, Teixeira MM, Allegretti M. Targeting the minor pocket of C5aR for the rational design of an oral allosteric inhibitor for inflammatory and neuropathic pain relief. Proc Natl Acad Sci USA. 2014 Nov 25;111(47):16937-42.

• Neves KB, Lobato NS, Lopes RA, Filgueira FP, Zanotto CZ, Oliveira AM, Tostes RC. Chemerin reduces vascular nitric oxide/cGMP signalling in rat aorta: a link to vascular dysfunction in obesity? Clin Sci (Lond). 2014 Jul;127(2):111-22.

• NEVES, KARLA ; LOBATO, NUBIA ; LOPES, RHEURE ; FILGUEIRA, FERNANDO ; ZANOTTO, CAMILA ; OLIVEIRA, ANA MARIA ; Tostes, Rita . Chemerin reduces vascular nitric oxide – cyclic guanosine monophosphate signaling: a link to vascular dysfunction in obesity?. Clinical Science (1979), v. 127, p. 111-122, 2014.

• Oliveira MG., Figueredo AS, Aquino GLB, Leopoldino AM, Silva VB, Taft CA, Silva, CHTP. In Silico Design of Phenylbenzamide Derivatives Coupled to Pyrimidines as Novel hnRNP K Ligands Against Cancer. Current Bioactive Compounds, v. 10, p. 158-162, 2014.

• PEREIRA, MARISTELA SOARES SWERTS; ROSSI, MARCOS A.; CARDOSO, CRISTINA RIBEIRO; DA SILVA, JOÃO SANTANA; BEZERRA DA SILVA, LÉA ASSED; KUGA, MILTON CARLOS; FARIA, GISELE. Cellular and Molecular Tissue Response to Triple Antibiotic Intracanal Dressing. Journal of Endodontics , v. 40, p. 499-504, 2014.

• Prates TP, Taira TM, Holanda MC, Bignardi LA, Salvador SL, Zamboni DS, Cunha FQ, Fukada SY. NOD2 contributes to Porphyromonas gingivalis-induced bone resorption. J Dent Res. 2014 Nov;93(11):1155-62.

• PROKOPCZYK, IGOR M; RIBEIRO, JEAN FR; SARTORI, GERALDO R; SESTI-COSTA, RENATA; SILVA, JOÃO S; FREITAS, RENATO F; LEITÃO, ANDREI; MONTANARI, CARLOS A. Integration of methods in cheminformatics and biocalorimetry for the design of trypanosomatid enzyme inhibitors. Future Medicinal Chemistry , v. 6, p. 17-33, 2014.

• Sacramento LA, Cunha FQ, de Almeida RP, da Silva JS, Carregaro V. Protective role of 5-lipoxigenase during Leishmania infantum infection is associated with Th17 subset. Biomed Res Int. 2014;2014:264270.

• Saia RS, Mestriner FL, Bertozi G, Cunha FQ, Cárnio EC. Cholecystokinin inhibits inducible nitric oxide synthase expression by lipopolysaccharide-stimulated peritoneal macrophages. Mediators Inflamm. 2014;2014:896029.

• Sanches SB, Osório FL, Louzada-Junior P, Moraes D, Crippa JA, Martín-Santos R. Association between joint hypermobility and anxiety in Brazilian university students: gender-related differences. J Psychosom Res. 2014 Dec;77(6):558-61.

• SANCHES, TIAGO L. M.; CUNHA, LARISSA D.; SILVA, GRACE K.; GUEDES, PAULO M. M.; SILVA, JOÃO SANTANA; ZAMBONI, DARIO S.. The Use of a Heterogeneously Controlled Mouse Population Reveals a Significant Correlation of Acute Phase Parasitemia with Mortality in Chagas Disease. Plos One , v. 9, p. e91640, 2014.


• Sesti-Costa R, Carneiro ZA, Silva MC, Santos M, Silva GK, Milanezi C, da Silva RS, Silva JS. Ruthenium complex with benznidazole and nitric oxide as a new candidate for the treatment of chagas disease. PLoS Negl Trop Dis. 2014 Oct 2;8(10):e3207.

• Silva JJN, Pavanelli WR, Panis C, Cunha TM, Oliveira FJA, Menezes MCND, Costa IC, Thomé GS, Silva FON, Sousa EHS, Lopes LGF, Cecchini R, Cunha FQ, Itano EN, Eharawatanabe MA. Nitric Oxide Donors with Therapeutic Strategic in Experimental Schistossomiasis Mansoni. American Journal of Immunology, v. 10, p. 225-239, 2014.

• SILVA, V. B.; LEOPOLDINO, A. M.; SILVA, C. H. T. P.. In silico bioisosteric replacements of hnRNP K ligands as anticancer lead compounds.. Current Physical Chemistry, v. 4, p. 30-34, 2014.

• Sônego F, Castanheira FV, Czaikoski PG, Kanashiro A, Souto FO, França RO, Nascimento DC, Freitas A, Spiller F, Cunha LD, Zamboni DS, Alves-Filho JC, Cunha FQ. MyD88-, but not Nod1- and/or Nod2-deficient mice, show increased susceptibility to polymicrobial sepsis due to impaired local inflammatory response. PLoS One. 2014 Aug 1;9(8):e103734.

• SÔNEGO, FABIANE; ALVES-FILHO, JOSÉ CARLOS; CUNHA, FERNANDO QUEIRÓZ. Targeting neutrophils in sepsis. Expert Review of Clinical Immunology , v. 28, p. 1-10, 2014.

• SOUSA, NATÁLIA GUIMARÃES KALATZIS; CARDOSO, CRISTINA RIBEIRO DE BARROS; SILVA, JOÃO SATANA DA; KUGA, MILTON CARLOS; TANOMARU-FILHO, MÁRIO; FARIA, GISELE. Association of matrix metalloproteinase inducer (EMMPRIN) with the expression of matrix metalloproteinases -1, -2 and -9 during periapical lesion development. Archives of Oral Biology , v. 59, p. 944-953, 2014.

• Staurengo-Ferrari, Larissa; Zarpelon, Ana C.; LONGHI-BALBINOT, DANIELA T.; MARCHESI, MARIO; Cunha, Thiago M.; ALVES-FILHO, JOSÉ C.; Cunha, Fernando Q.; Ferreira, Sergio H.; Casagrande, Rubia; MIRANDA, KATRINA M.; Verri, Waldiceu A.. Nitroxyl inhibitsovert pain-like behavior in mice: Role of cGMP/PKG/ATP-sensitive potassium channel signaling pathway. Pharmacological Reports , v. 66, p. 691-698, 2014.

• Tamashiro, LF., Oliveira, RDR., Oliveira, R, Frota, ERC., Donadi, EA, Del-Ben, CM., Teixeira, AL, Louzada-Junior, P. Participation of the neutrophin brain-derived neurotrophic factor in neuropsychiatric systemic lupus erythematosus. Rheumatology (Oxford. Print). , v.53, p.2182 – 2190, 2014 [Impact Factor 4.5]


• Vigato-Ferreira, ICC, Toller-Kawahisa, JE, Pancoto, JAT, Mendes-Junior, CT, Martinez,EZ; Donadi, EA, Louzada-Júnior, P, Del Lama, JEC, Marzocchi-Machado, CM FcRIIa and FcRIIIb polymorphisms and associations with clinical manifestations in systemic lupus erythematosus patients. Autoimmunity (Amsterdam. Print). , v.47, p.451 – 458, 2014

• Wanderley CW, Silva CM, Wong DV, Ximenes RM, Morelo DF, Cosker F, Aragão KS, Fernandes C, Palheta-Júnior RC, Havt A, Brito GA, Cunha FQ, Ribeiro RA, Lima-Júnior RC. Bothrops jararacussu snake venom-induces a local inflammatory response in a prostanoid- and neutrophil-dependent manner. Toxicon. 2014 Nov;90:134-47.